Protein Alignment DIS3L2 and dis3l2

DIOPT Version :10

• Sequence 1: NP_689596.4
• Gene: DIS3L2 / 129563
• HGNCID: 28648
• Length: 885
• Species: Homo sapiens
• Sequence 2: XP_005163305.1
• Gene: dis3l2 / 566106
• ZFINID: ZDB-GENE-070705-171
• Length: 995
• Species: Danio rerio
• Alignment Length: 835
• Identity: 522/835 - (62%)
• Similarity: 634/835 - (75%)
• Gaps: 61/835 - (7%)

Human    29 GASPGDKKSKN-RSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDR 92
            |:...|||..| :..|...|.:||.|||.||||.|||||.||||||||||||:.||:||||||..
Zfish   215 GSRQIDKKDINAKDGRASGKQVFEQYMSVEDVSAGLKRGELIQGVLRINPKKYKEAYIPSPDGSA 279

Human    93 DIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKS 157
            |||:||:.|||||||||:||||:||.|..:..|
Zfish   280 DIFLDGISARNRALNGDVVVVKVLPLEQSQATK-------------------------------- 312

Human   158 YNDSPDVIVEAQFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKD-ETTCISQDT 221
               :|||||||.::|.|.          :|..::|:|:       .|.....|:. |....|...
Zfish   313 ---TPDVIVEAHYNGDDE----------MVSKMEKVSL-------NDKALLTTQSVEHATTSNTP 357

Human   222 RALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSPSDHRVPRIYVPLKDCP 286
            .:.||::.|::.|||:|:|||||||.:||||.|.:|      ::|:|||.||||||:.|||.|||
Zfish   358 ASSSERTTQKNGKVVFIVEKKHSRAVSGFLKFLPNK------RFAMFSPVDHRVPRVNVPLADCP 416

Human   287 QDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEV 351
            .||.:||.||.||||||||..|..|.|||.|:|||:|||||||||||||||||||||||:|:.||
Zfish   417 ADFTSRPGDYENTLFICRITQWPADSNFAEGRLAKTLGQAGEIEPETEGILTEYGVDFSEFTEEV 481

Human   352 LECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYF 416
            |.||||.|||:||..|.|.||||||:|||||||:||||||||||||.|:||||:|||||||||||
Zfish   482 LNCLPQDLPWSIPAHELSTRRDLRKECIFTIDPATARDLDDALSCKQLSDGNFEVGVHIADVSYF 546

Human   417 VPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWF 481
            |.||:.||::|.:|||||||||||:||||||||||||||||::|:|||||||.|:||||||.|||
Zfish   547 VKEGNALDELAGQRATSVYLVQKVIPMLPRLLCEELCSLNPLTDRLTFSVIWKLSPEGKILSEWF 611

Human   482 GRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLRQQRFVD 546
            |||:|.||.||||:||||||::|.:....:|||..||.||..|:.:||||||.||||||.|||..
Zfish   612 GRTVICSCIKLSYDHAQSMIDAPDKHFSPEELPACSPNHSIIEIQEAVLNLHNIAKQLRAQRFEG 676

Human   547 GALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPEQALLRRHP 611
            ||||||||||:||||.|:.:||||::|:||:||||||||||||||||.|:|:|::||.|||||||
Zfish   677 GALRLDQLKLSFTLDKESSMPQGCYVYQYRDSNKLVEEFMLLANMAVGHQIYRSYPELALLRRHP 741

Human   612 PPQTRMLSDLVEFCDQMGLPVDFSSAGALNKSLTQTFGDDKYSLARKEVLTNMCSRPMQMALYFC 676
            ||||:|:.|:.||.|||||.:||||:|||::||.:..|||:|:.|||||:|:|||||||||:|||
Zfish   742 PPQTKMVDDMQEFFDQMGLDIDFSSSGALHRSLNENLGDDEYTAARKEVITHMCSRPMQMAVYFC 806

Human   677 SGLLQDPAQFRHYALNVPLYTHFTSPIRRFADVLVHRLLAAALGYRERLDMAPDTLQKQADHCND 741
            :|.|:|...||||||||||||||||||||:|||:|||||.|:|....||.::.:.:.:||.||||
Zfish   807 AGALKDEKLFRHYALNVPLYTHFTSPIRRYADVIVHRLLGASLNCGPRLSVSGEEVHQQASHCND 871

Human   742 RRMASKRVQELSTSLFFAVLVKESGPLESEAMVMGILKQAFDVLVLRYGVQKRIYCNAL-ALRSH 805
            |:.|||||||||:.|||||.|||.|||:|||||||:|.|:|||||||||||||||||:| .|:..
Zfish   872 RKTASKRVQELSSELFFAVFVKECGPLDSEAMVMGVLDQSFDVLVLRYGVQKRIYCNSLEGLKEV 936

Human   806 HFQKVGKKPELTLVWEPEDMEQEPAQQVITIFSLVEVVLQAESTALKYSAILKRP 860
            .|:|||||||:|||||.:|..::..:|.|:||:|:.|.|:|:...:||||.||||
Zfish   937 EFRKVGKKPEMTLVWETDDPSKDSIKQEISIFTLLNVQLKADGAPMKYSATLKRP 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIS3L2	NP_689596.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		6/16 (38%)
		Rrp44_CSD1	50..238	CDD:375054	78/188 (41%)
		VacB	231..745	CDD:440323	362/513 (71%)
		Dis3l2_C_term	766..855	CDD:465547	55/89 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	860..885		1/1 (100%)
dis3l2	XP_005163305.1	VacB	251..872	CDD:440323	424/678 (63%)
		Dis3l2_C_term	896..986	CDD:465547	55/89 (62%)