Protein Alignment DIS3L2 and Dis3l2

DIOPT Version :10

• Sequence 1: NP_689596.4
• Gene: DIS3L2 / 129563
• HGNCID: 28648
• Length: 885
• Species: Homo sapiens
• Sequence 2: NP_001102477.2
• Gene: Dis3l2 / 367307
• RGDID: 1560168
• Length: 890
• Species: Rattus norvegicus
• Alignment Length: 895
• Identity: 768/895 - (85%)
• Similarity: 816/895 - (91%)
• Gaps: 19/895 - (2%)

Human     1 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKR 65
            |:||||::||:..|||||||:|.||:.:|||||||||||:|.||||||||||||||||||||||:
  Rat     1 MNHPDYKLNLQSPGTPRGVSSVVGPNAVGASPGDKKSKNKSMRGKKKSIFETYMSKEDVSEGLKK 65

Human    66 GTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKV------- 123
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:.||.
  Rat    66 GTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEDQWKPRITLSLP 130

Human   124 -------VKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHGI 181
                   ||||||||||||..|:||.||.|||||.|:|.|.:| .||||:|||||.|||||.||.
  Rat   131 GVLGLQGVKPESNDKETEATNETDISEESCGHHLLQKSPKGWN-GPDVIIEAQFDDSDSEDRHGN 194

Human   182 TQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRA 246
            |.. ||||:||||||..:||:||..|||.|||.|..|||||||||||||:|||||||||||||||
  Rat   195 TSG-LVDGMKKLSVCTPDKGKEDSSAPVMKDENTPKSQDTRALSEKSLQKSAKVVYILEKKHSRA 258

Human   247 ATGFLKLLADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKED 311
            |||.|||||||||:||:||||||||||||||||||||||||||:.||||||||||||||:|||||
  Rat   259 ATGILKLLADKNSDLFKKYALFSPSDHRVPRIYVPLKDCPQDFMTRPKDYANTLFICRIIDWKED 323

Human   312 CNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLPWTIPPEEFSKRRDLRK 376
            ||||||||||||||||||||||||||||||||||||||||||||||.|||||||||..|||||||
  Rat   324 CNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQSLPWTIPPEEVGKRRDLRK 388

Human   377 DCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVV 441
            ||||||||||||||||||||:.|.||.|:||||||||||||||||.|||||||||||||||||||
  Rat   389 DCIFTIDPSTARDLDDALSCRQLTDGTFEVGVHIADVSYFVPEGSSLDKVAAERATSVYLVQKVV 453

Human   442 PMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTE 506
            |||||||||||||||||:|||||||||.||||||||:||||||||||||||||:|||||||:|||
  Rat   454 PMLPRLLCEELCSLNPMTDKLTFSVIWKLTPEGKILEEWFGRTIIRSCTKLSYDHAQSMIENPTE 518

Human   507 KIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCH 571
            |||.:||||||||||.|||||||||||.||||||:||||||||||||||||||||||||||||||
  Rat   519 KIPKEELPPISPEHSIEEVHQAVLNLHSIAKQLRRQRFVDGALRLDQLKLAFTLDHETGLPQGCH 583

Human   572 IYEYRESNKLVEEFMLLANMAVAHKIHRAFPEQALLRRHPPPQTRMLSDLVEFCDQMGLPVDFSS 636
            |||||:||||||||||||||||||||.|.|||||||||||||||:|||||||||||||||:|.||
  Rat   584 IYEYRDSNKLVEEFMLLANMAVAHKIFRTFPEQALLRRHPPPQTKMLSDLVEFCDQMGLPMDVSS 648

Human   637 AGALNKSLTQTFGDDKYSLARKEVLTNMCSRPMQMALYFCSGLLQDPAQFRHYALNVPLYTHFTS 701
            |||||||||.||||||||||||||||||.|||||||||||||:|||.||||||||||||||||||
  Rat   649 AGALNKSLTNTFGDDKYSLARKEVLTNMYSRPMQMALYFCSGMLQDQAQFRHYALNVPLYTHFTS 713

Human   702 PIRRFADVLVHRLLAAALGYRERLDMAPDTLQKQADHCNDRRMASKRVQELSTSLFFAVLVKESG 766
            ||||||||:|||||||||||.|:.|:.||.||||||||||||||||||||||..|||::||||||
  Rat   714 PIRRFADVIVHRLLAAALGYSEQPDVEPDALQKQADHCNDRRMASKRVQELSIGLFFSILVKESG 778

Human   767 PLESEAMVMGILKQAFDVLVLRYGVQKRIYCNALALRSHHFQKVGKKPELTLVWEPEDMEQEPAQ 831
            ||||||||||:|.|||||||||:|||||||||||||||:|||||||||||||||||:|:|:||.|
  Rat   779 PLESEAMVMGVLNQAFDVLVLRFGVQKRIYCNALALRSYHFQKVGKKPELTLVWEPDDLEEEPIQ 843

Human   832 QVITIFSLVEVVLQAESTALKYSAILKRPGTQGHLGPEKEEEESDGEPED 881
            |||||||||:||||||:|||||||||||||.:..||.||   |||.||||
  Rat   844 QVITIFSLVDVVLQAEATALKYSAILKRPGPEHSLGLEK---ESDEEPED 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIS3L2	NP_689596.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		30/43 (70%)
		Rrp44_CSD1	50..238	CDD:375054	152/201 (76%)
		VacB	231..745	CDD:440323	470/513 (92%)
		Dis3l2_C_term	766..855	CDD:465547	78/88 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	860..885		13/22 (59%)
Dis3l2	NP_001102477.2	Rrp44_CSD1	50..>159	CDD:375054	86/108 (80%)
		VacB	245..757	CDD:440323	469/511 (92%)
		Dis3l2_C_term	778..867	CDD:465547	78/88 (89%)