Protein Alignment DIS3L2 and dis32

DIOPT Version :10

• Sequence 1: NP_689596.4
• Gene: DIS3L2 / 129563
• HGNCID: 28648
• Length: 885
• Species: Homo sapiens
• Sequence 2: NP_594510.1
• Gene: dis32 / 2542643
• PomBaseID: SPAC2C4.07C
• Length: 927
• Species: Schizosaccharomyces pombe
• Alignment Length: 808
• Identity: 286/808 - (35%)
• Similarity: 406/808 - (50%)
• Gaps: 135/808 - (16%)

Human    35 KKSKNRS--------------TRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFI 85
            |:.||.|              :...|||::..|.....|.:|||.|||.:|.|||  .:.|.:..
pombe   147 KREKNNSHQVEADTNNATEMVSSNAKKSVYPLYYDSATVKKGLKSGTLFKGTLRI--LENHRSAF 209

Human    86 PSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHL 150
            ...:...|.::||.:|||||.:.|:|           :|:|..|
pombe   210 ACMEDIPDFYVDGPIARNRAFHNDVV-----------IVEPVMN--------------------- 242

Human   151 PQQSLKSYNDSPDVIVEAQFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETT 215
                    ||||..                 ..|.|.:||:|:.:       :|.|     ||..
pombe   243 --------NDSPTE-----------------KSNFLQNGVEKVKI-------KDHD-----DELG 270

Human   216 CISQDTRALSEKSL-------QRSAKVVYILEKKHSRAATGFLKL--LADKNSELFRK---YALF 268
            ...:....|..||:       :..|:||.|.::.......|.|:.  .:.||.|...|   ||:|
pombe   271 GAMEHLERLEIKSVASFKGDSRTRARVVAIEKRAEISKIVGILRAPGWSLKNVEYVSKKSSYAIF 335

Human   269 SPSDHRVPRIYVPLKDCP----QDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEI 329
            .|.|.|:|.|.:...|..    ::::.....:.:.||...|..|.....:.:|.|.:.||...::
pombe   336 IPKDKRLPFITIHKNDLSDLSGENWIENILKHHDQLFSVEITRWSIYSRYPMGVLGEKLGNITDV 400

Human   330 EPETEGILTEYGVDFSDFSSEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDAL 394
            |..|..:|.|.|:..|.||.|||.|||.. .|.|..||..||||||.:.|.||||.||||||||:
pombe   401 EAYTNALLLENGISSSPFSDEVLNCLPPD-DWIISHEEIKKRRDLRNELIITIDPETARDLDDAV 464

Human   395 SCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMS 459
            ||:.|.:|.::||||||||::||...|.|||.||.|||:||||||.:||||.||||.||||||..
pombe   465 SCRALDNGTYEVGVHIADVTHFVKPDSALDKEAASRATTVYLVQKAIPMLPPLLCERLCSLNPNV 529

Human   460 DKLTFSVIWTLTPEGK-ILDEWFGRTIIRSCTKLSYEHAQSMIESPT-EKIPAKELPPISPEHSS 522
            ::|.|||.|.|...|| |...|||:|:|::|.:|:|..||.:||..: :....|   ||...|:.
pombe   530 ERLAFSVFWKLDSNGKEIGKRWFGKTVIKTCARLAYSEAQGVIEGKSWDDAVGK---PIGGTHTP 591

Human   523 EEVHQAVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFML 587
            ::|..::|.|..|:::||:.||..||:.::..:|.|.|| |.|:|..|.:||..::|.|:|||||
pombe   592 KDVETSILTLCEISRKLRKDRFAKGAVEINSTELKFQLD-EYGMPNKCEVYEQTDANHLIEEFML 655

Human   588 LANMAVAHKIHRAFPEQALLRRHPPPQTRMLSDLVEFCDQMGLPVDFSSAGALNKS---LTQTFG 649
            |||.:||..|.:.|...:|||||..|:.:.:::...|...|....|.||:.|.|.|   |..||.
pombe   656 LANRSVAEHISKNFSNNSLLRRHASPKEKQINEFCHFLKSMNFDFDASSSAAFNASMVRLRSTFN 720

Human   650 DDKYSLARKEVLTNMCSRPMQMALYFCSGLLQDPAQFRHYALNVPLYTHFTSPIRRFADVLVHRL 714
            ::..     |:..||..|.:..|.|||:|...:...:.||||:...||||||||||:.|::||||
pombe   721 EELV-----ELFENMAVRSLNRAEYFCTGDFGEKTDWHHYALSFNHYTHFTSPIRRYPDIIVHRL 780

Human   715 LAAALGYRERLDMAPDTLQKQ----ADHCNDRRMASKRVQELSTSLFFAVLV--------KESGP 767
            |..:|     .:.:|...:|.    |.|||:::..|..|||.|..||.:|.:        |:|.|
pombe   781 LERSL-----KNTSPGIDKKNCSLVAAHCNEKKEKSTTVQEDSQQLFLSVYIAEYCKKHDKKSMP 840

Human   768 LESEAMVMGILKQAFDVLVLRYGVQKRI 795
            :  :|....|...:.||.:..||:..|:
pombe   841 V--QAFATRISGNSIDVYISEYGISNRV 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIS3L2	NP_689596.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		4/23 (17%)
		Rrp44_CSD1	50..238	CDD:375054	45/194 (23%)
		VacB	231..745	CDD:440323	219/531 (41%)
		Dis3l2_C_term	766..855	CDD:465547	8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	860..885
dis32	NP_594510.1	Rrp44_CSD1	176..314	CDD:375054	47/208 (23%)
		VacB	267..862	CDD:440323	240/611 (39%)