Protein Alignment DIS3L2 and Dis3l2

DIOPT Version :10

• Sequence 1: NP_689596.4
• Gene: DIS3L2 / 129563
• HGNCID: 28648
• Length: 885
• Species: Homo sapiens
• Sequence 2: NP_001165628.1
• Gene: Dis3l2 / 208718
• MGIID: 2442555
• Length: 884
• Species: Mus musculus
• Alignment Length: 895
• Identity: 760/895 - (84%)
• Similarity: 808/895 - (90%)
• Gaps: 25/895 - (2%)

Human     1 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKR 65
            |:||||::|||..|||||||:|.||..:|||||||||||:|.|||||||||||||||||||||||
Mouse     1 MNHPDYKLNLRSPGTPRGVSSVVGPSAVGASPGDKKSKNKSMRGKKKSIFETYMSKEDVSEGLKR 65

Human    66 GTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWK-------- 122
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:.||
Mouse    66 GTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEDQWKPRITLSLP 130

Human   123 ------VVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHGI 181
                  .|||||||||.||.||:|||||.||||..|||.|.:: .||||:|||||.|||||.||.
Mouse   131 GVLGLQAVKPESNDKEIEATYEADIPEEGCGHHPLQQSRKGWS-GPDVIIEAQFDDSDSEDRHGN 194

Human   182 TQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRA 246
            |.. |||||||||:...::|:||...||.|||.|.|.||||.|||||||:|||||||||||||||
Mouse   195 TSG-LVDGVKKLSISTPDRGKEDSSTPVMKDENTPIPQDTRGLSEKSLQKSAKVVYILEKKHSRA 258

Human   247 ATGFLKLLADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKED 311
            |||.|||||||||:||:||||||||||||||||||||||||||:.||||:|||||||||:|||||
Mouse   259 ATGILKLLADKNSDLFKKYALFSPSDHRVPRIYVPLKDCPQDFMTRPKDFANTLFICRIIDWKED 323

Human   312 CNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLPWTIPPEEFSKRRDLRK 376
            ||||||||||||||||||||||||||||||||||||||||||||||.|||||||:|..|||||||
Mouse   324 CNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQSLPWTIPPDEVGKRRDLRK 388

Human   377 DCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVV 441
            ||||||||||||||||||:|:.|.||.|:||||||||||||||||.|||||||||||||||||||
Mouse   389 DCIFTIDPSTARDLDDALACRRLTDGTFEVGVHIADVSYFVPEGSSLDKVAAERATSVYLVQKVV 453

Human   442 PMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTE 506
            |||||||||||||||||:|||||||||.||||||||:||||||||||||||||:|||||||:|||
Mouse   454 PMLPRLLCEELCSLNPMTDKLTFSVIWKLTPEGKILEEWFGRTIIRSCTKLSYDHAQSMIENPTE 518

Human   507 KIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCH 571
            |||.:||||||||||.|||||||||||.||||||:||||||||||||||||||||||||||||||
Mouse   519 KIPEEELPPISPEHSVEEVHQAVLNLHSIAKQLRRQRFVDGALRLDQLKLAFTLDHETGLPQGCH 583

Human   572 IYEYRESNKLVEEFMLLANMAVAHKIHRAFPEQALLRRHPPPQTRMLSDLVEFCDQMGLPVDFSS 636
            |||||:||||||||||||||||||||.|.|||||||||||||||:|||||||||||||||:|.||
Mouse   584 IYEYRDSNKLVEEFMLLANMAVAHKIFRTFPEQALLRRHPPPQTKMLSDLVEFCDQMGLPMDVSS 648

Human   637 AGALNKSLTQTFGDDKYSLARKEVLTNMCSRPMQMALYFCSGLLQDPAQFRHYALNVPLYTHFTS 701
            |||||||||:||||||||||||||||||.|||||||||||||:|||..|||||||||||||||||
Mouse   649 AGALNKSLTKTFGDDKYSLARKEVLTNMYSRPMQMALYFCSGMLQDQEQFRHYALNVPLYTHFTS 713

Human   702 PIRRFADVLVHRLLAAALGYRERLDMAPDTLQKQADHCNDRRMASKRVQELSTSLFFAVLVKESG 766
            ||||||||:|||||||||||.|:.|:.|||||||||||||||||||||||||..|||||||||||
Mouse   714 PIRRFADVIVHRLLAAALGYSEQPDVEPDTLQKQADHCNDRRMASKRVQELSIGLFFAVLVKESG 778

Human   767 PLESEAMVMGILKQAFDVLVLRYGVQKRIYCNALALRSHHFQKVGKKPELTLVWEPEDMEQEPAQ 831
            ||||||||||:|.|||||||||:|||||||||||||||:.||||||||||||||||:|:|:||.|
Mouse   779 PLESEAMVMGVLNQAFDVLVLRFGVQKRIYCNALALRSYSFQKVGKKPELTLVWEPDDLEEEPTQ 843

Human   832 QVITIFSLVEVVLQAESTALKYSAILKRPGTQGHLGPEKEEEESDGEPED 881
            |||||||||:||||||:|||||||||||||.         |:.||.||||
Mouse   844 QVITIFSLVDVVLQAEATALKYSAILKRPGL---------EKASDEEPED 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIS3L2	NP_689596.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		31/43 (72%)
		Rrp44_CSD1	50..238	CDD:375054	149/201 (74%)
		VacB	231..745	CDD:440323	467/513 (91%)
		Dis3l2_C_term	766..855	CDD:465547	77/88 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	860..885		9/22 (41%)
Dis3l2	NP_001165628.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		31/43 (72%)
		Rrp44_CSD1	50..250	CDD:375054	149/201 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..237		33/54 (61%)
		VacB	228..757	CDD:440323	479/528 (91%)
		Dis3l2_C_term	778..867	CDD:465547	77/88 (88%)