Protein Alignment DIS3L2 and disl-2

DIOPT Version :10

• Sequence 1: NP_689596.4
• Gene: DIS3L2 / 129563
• HGNCID: 28648
• Length: 885
• Species: Homo sapiens
• Sequence 2: NP_498160.2
• Gene: disl-2 / 175748
• WormBaseID: WBGene00018612
• Length: 848
• Species: Caenorhabditis elegans
• Alignment Length: 884
• Identity: 353/884 - (39%)
• Similarity: 511/884 - (57%)
• Gaps: 110/884 - (12%)

Human    16 PRGVSAVAGPHDIGASPGDK----KSK---------NRSTRGKKKSIFETYMSKEDVSEGLKRGT 67
            |:|::..|.....||:...|    |:|         |.......:.||..|:|||:...|::.|:
 Worm    18 PQGLTQTATGGKFGAAATVKTTPTKAKPYVKPQNANNLQNNFNPRKIFTEYISKEETDAGIEDGS 82

Human    68 LIQGVLRINPKKFHEAFIPSPDGDR--DIFIDGVVARNRALNGDLVVVKLLPEEHWKV-----VK 125
            :.:||||||||.:.|.|:..|.|..  |:.:.| ..||||:.||:|.||:.|:|.|.|     ||
 Worm    83 MFKGVLRINPKNYQECFLDHPKGTNHPDVLVLG-QDRNRAMQGDVVAVKIKPKEDWLVNYVEYVK 146

Human   126 PESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHGITQNVLVDGV 190
            ..:..|:.:                 :.|.|:.|:||:
 Worm   147 WWAEHKKGD-----------------RNSGKTDNNSPN--------------------------- 167

Human   191 KKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLL- 254
            |....|:..:.:::|   ||.||          :.:..|.....:|:||||||.|.|.|.|:|:
 Worm   168 KTEKRCLRNEIQDNG---VTSDE----------VPDSCLITIGAIVHILEKKHFRVAAGKLQLMP 219

Human   255 --ADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALG 317
              |:.|       .||..:|.|||||.:|..|..::|.:||||:...|:..:|.||:.:..:|.|
 Worm   220 NSANPN-------VLFVATDSRVPRILIPKSDVDKEFFSRPKDFERFLYTAKITDWRAESVYADG 277

Human   318 QLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLP--QGLPWTIPPEEFSKRRDLRKDCIF 380
            :|.|.||.:|||:.|||.|:.|:.:|..:||.|.||.||  ....|.:|..||..|||.|.|.:|
 Worm   278 RLVKLLGMSGEIDTETERIVYEHQIDHREFSDECLESLPITTAENWKVPDAEFEYRRDFRSDIVF 342

Human   381 TIDPSTARDLDDALSCKPLADGNFK------VGVHIADVSYFVPEGSDLDKVAAERATSVYLVQK 439
            ||||.|||||||||..|.:.|.:.|      :|||||||::|:.||::|||.|:||..|.||.|.
 Worm   343 TIDPKTARDLDDALHAKHIDDCDGKGTPGLEIGVHIADVTFFLKEGTELDKWASERGNSTYLSQT 407

Human   440 VVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESP 504
            |:|||||:|||:||||||..|:|:||.::.::.|.::.|.||||::|||..||:|||||..||:|
 Worm   408 VIPMLPRILCEQLCSLNPGVDRLSFSTVFKMSYEAELYDVWFGRSVIRSRVKLAYEHAQDFIENP 472

Human   505 TEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQG 569
            .:.....|||.||..::..|:.:..|.||.||:.|||:|...||||::..:|.|.|| |...|||
 Worm   473 EKDFTCDELPDISDGNTPFEIKEKTLMLHRIAQVLRQKREDSGALRIELPRLKFALD-EDKKPQG 536

Human   570 CHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPEQALLRRHPPPQTRMLSDLVEFCDQMGLPVDF 634
            ..|||.::||||||||||||||.||.||...|||.||||.||||:.:|:.|:.|.|.::|.|:|.
 Worm   537 VSIYEIKDSNKLVEEFMLLANMEVAKKIAENFPEHALLRNHPPPKEKMIKDVAEQCARIGFPLDG 601

Human   635 SSAGALNKSLTQTFGDDKYSLARKEVLTNMCSRPMQMALYFCSGLLQDPAQF-RHYALNVPLYTH 698
            .::|.|:.||.:..|..:..:..::|::::..:|||.|.|||:  .:.|..| .|:||||..|||
 Worm   602 RTSGLLSTSLRKYQGKSRLDMCIRQVISSLTIKPMQQAKYFCT--FEMPLSFYHHFALNVDHYTH 664

Human   699 FTSPIRRFADVLVHRLLAAALGYRERLDMAPDTLQKQADHCNDRRMASKRVQELSTSLFFAVLVK 763
            |||||||:.||:|||.|||||||.||.:..|:.:|:....|||.::|||...:.|..|:|.|.:.
 Worm   665 FTSPIRRYPDVIVHRQLAAALGYNERSERVPEEIQEICTRCNDTKLASKEASDESAMLYFGVFIH 729

Human   764 ESGPLESEAMVMGILKQAFDVLVLRYGVQKRIYCNALALRSHHFQKVGKKPELTLVW--EP--ED 824
            ::||::.:|:|:|::..:||||::.|||.||:|.:.:   ...|.|..:|  ||:.|  :|  |.
 Worm   730 QTGPMKCQAVVLGVMDLSFDVLIVEYGVVKRVYVDKM---KRDFNKSTEK--LTIYWPADPNAES 789

Human   825 MEQEPAQQVITIFSLVEVVLQAESTALKYSAILKRPGTQ 863
            ..:|.....|.:.::|.|:| ....:::.||.:.||..:
 Worm   790 GNREEFSSSIQMCNVVYVIL-VPYKSIEVSATIVRPSLE 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIS3L2	NP_689596.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		9/41 (22%)
		Rrp44_CSD1	50..238	CDD:375054	51/194 (26%)
		VacB	231..745	CDD:440323	254/525 (48%)
		Dis3l2_C_term	766..855	CDD:465547	28/92 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	860..885		1/4 (25%)
disl-2	NP_498160.2	VacB	78..723	CDD:440323	302/712 (42%)
		Dis3l2_C_term	732..802	CDD:465547	25/74 (34%)