Protein Alignment COL6A2 and col6a2

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: XP_021335547.1
• Gene: col6a2 / 567771
• ZFINID: ZDB-GENE-070501-7
• Length: 1090
• Species: Danio rerio
• Alignment Length: 1032
• Identity: 626/1032 - (60%)
• Similarity: 757/1032 - (73%)
• Gaps: 34/1032 - (3%)

Human     7 SVLLLWGILGAIQAQQQEVISPDTTERNNNC--------PEKTDCPIHVYFVLDTSESVTMQ-SP 62
            |:|||  :...:.||.|       |...::|        .|.|:|||.:||.:||||::.:| :|
Zfish    74 SILLL--LFVGVHAQGQ-------TPAGSSCSPIMCSVPSESTECPIDLYFAIDTSETIALQENP 129

Human    63 TDILLFHMKQFVPQFISQLQNEFYLDQVALSWRYGGLHFSDQVEVFSPPGSDRASFIKNLQGISS 127
            ...|:..:|.|..:|..:|||..|...|.::|..||||||...|.||.. :.:..||.||:.|..
Zfish   130 PGSLVESIKDFTIRFAEKLQNVNYRGSVNITWAIGGLHFSQLQEFFSTI-TTKEKFISNLRPIRY 193

Human   128 FRRGTFTDCALANMTEQI-----RQDRSKGTVHFAVVITDGHVTGSPCGGIKLQAERAREEGIRL 187
            ..|||..|||:.|||:|:     |.|..:    |||||||||||.:||||||:.|||||:|.||:
Zfish   194 LGRGTHIDCAITNMTKQLVRFPSRPDAKR----FAVVITDGHVTANPCGGIKVAAERARDENIRI 254

Human   188 FAVAPNQNLKEQGLRDIASTPHELYRNDYATMLPDSTE--IDQDTINRIIKVMKHEAYGECYKVS 250
            ||||.::||:|.|||:||::|..:||:.|..:....|.  |...||:||...|.|.||.|||...
Zfish   255 FAVASSRNLEETGLREIANSPAGVYRDKYMAVNLTGTRPVIVTSTIDRIYDTMLHMAYQECYSTK 319

Human   251 CLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGAD 315
            |||.|||.||.|:||||||||:.|..|..|::||.||||||||||.|||||.||.||||||.||.
Zfish   320 CLETPGPPGPPGHRGQKGAKGDNGGAGLKGERGRPGDPGIEGPIGHPGPKGEPGLKGEKGEIGAQ 384

Human   316 GRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKGDPGRPGR 380
            |:||..|:||::|.||||||.||||.||||||||::||||:||:.|.||..|..|.|||.|||||
Zfish   385 GKKGVAGIAGRDGKDGQKGKFGRIGAPGCKGDPGDKGPDGHPGDVGEPGLPGALGDKGDRGRPGR 449

Human   381 RGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKG 445
            .||||..|..|.||.:|:.|:||.||.||..|..|..||||:.|||||.|.|||.|.:|.|||||
Zfish   450 SGPPGPAGDPGPKGERGSPGSPGIPGTKGGAGTAGGPGPKGDAGRRGDFGPKGSTGPNGAKGEKG 514

Human   446 DPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDP 510
            :||.|||||||||||.||:|||.||||||||.||.|:.|::||.|||||:|||||.|.||||||.
Zfish   515 EPGAEGPRGLAGEVGGKGSKGDNGLPGPRGPPGAPGDAGRKGSSGDPGDSGPRGDPGPPGPKGDS 579

Human   511 GRPGFSYPGPRGAPGEKGEPGPRGPEGGRGDFGLKGEPGRKGEKGEPADPGPPGEPGPRGPRGVP 575
            ||||||||||||..|::||.|..||.|.|||.|.||:||.||..|||.:|||.||||.|||||..
Zfish   580 GRPGFSYPGPRGPTGDRGEKGSPGPRGSRGDCGPKGDPGLKGTPGEPGEPGPAGEPGQRGPRGDG 644

Human   576 GPEGEPGPPGDPGLTECDVMTYVRETCGCCDCEKRCGALDVVFVIDSSESIGYTNFTLEKNFVIN 640
            |.:|:|||.|||||||||||.|:|||||||||||||||||:|||||||||:|.||||||||||||
Zfish   645 GRDGDPGPEGDPGLTECDVMNYIRETCGCCDCEKRCGALDIVFVIDSSESVGLTNFTLEKNFVIN 709

Human   641 VVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIQLDDERIDSLSSFKEAVKNLEWIAGGTWTPS 705
            .:||||:|||||.||||||||||||||.|||:||:|:|.:|||:|:||:|||.||||||||||||
Zfish   710 TINRLGSIAKDPSSETGTRVGVVQYSHNGTFQAIRLNDSKIDSMSAFKDAVKKLEWIAGGTWTPS 774

Human   706 ALKFAYDRLIKESRRQKTRVFAVVITDGRHDPRDDDLNLRALC-DRDVTVTAIGIGDMFHEKHES 769
            |||||||.||::|||.|..|..|||||||:||||||..|..|| |..:.|.||||||||.:..|:
Zfish   775 ALKFAYDNLIRDSRRSKANVTVVVITDGRYDPRDDDKLLNYLCTDTSIDVNAIGIGDMFDQPEEN 839

Human   770 ENLYSIACDKPQQVRNMTLFSDLVAEKFIDDMEDVLCPDPQIVCPDLPCQTELSVAQCTQRPVDI 834
            |:|.||||.|..:|..|..|:|||||.|||.:|.||||||.::||||||::|.:||.|.|||||:
Zfish   840 ESLKSIACRKDGRVMGMRRFADLVAEDFIDRIETVLCPDPVVICPDLPCKSEPAVANCIQRPVDL 904

Human   835 VFLLDGSERLGEQNFHKARRFVEQVARRLTLARRDDDPLNARVALLQFGGPGEQQVAFPLSHNLT 899
            ||:||||||:|::||..||.|||.||.|||||:.|||..||||||||:|...:.|:||.|::|.|
Zfish   905 VFMLDGSERMGQENFRYAREFVENVANRLTLAQGDDDERNARVALLQYGDENQHQLAFKLTNNFT 969

Human   900 AIHEALETTQYLNSFSHVGAGVVHAINAIVRSPRGG--ARRHAELSFVFLTDGVTGNDSLHESAH 962
            .|.:.|...:||:|.|:||:|:::|||.||.| ||.  |||:|||||||:|||||.|.:|.|...
Zfish   970 VIADGLANMRYLDSTSNVGSGIIYAINNIVTS-RGTRLARRNAELSFVFITDGVTSNKNLEEGIS 1033

Human   963 SMRKQNVVPTVLALGSDVDMDVLTTLSLGDRAAVFHEKDYDSLAQPGFFDRFIRWIC 1019
            :||:...||||:|:.:|||.::|..:||||:.|||..:|:..|.:..||:||:||||
Zfish  1034 AMRRAEGVPTVIAMSNDVDKEILAKISLGDQTAVFRGEDFARLNKASFFERFVRWIC 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256		110/250 (44%)
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757	90/195 (46%)
		gly_rich_SclB	<255..>513	CDD:468478	176/257 (68%)
		Triple-helical region	257..590		226/332 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		224/330 (68%)
		Cell attachment site. /evidence=ECO:0000255	366..368		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	426..428		1/1 (100%)
		Collagen	487..556	CDD:460189	48/68 (71%)
		Cell attachment site. /evidence=ECO:0000255	489..491		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	498..500		1/1 (100%)
		Cell attachment site. /evidence=ECO:0000255	539..541		1/1 (100%)
		Nonhelical region	591..1019		279/430 (65%)
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757	136/191 (71%)
		VWA	833..1007	CDD:459670	97/175 (55%)
col6a2	XP_021335547.1	vWFA	109..283	CDD:469594	87/178 (49%)
		gly_rich_SclB	<334..>631	CDD:468478	201/296 (68%)
		vWFA	681..872	CDD:469594	136/190 (72%)
		VWA	903..1078	CDD:459670	97/175 (55%)