DRSC/TRiP Functional Genomics Resources

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Protein Alignment COL6A2 and col-78

DIOPT Version :10

Sequence 1:NP_001840.3 Gene:COL6A2 / 1292 HGNCID:2212 Length:1019 Species:Homo sapiens
Sequence 2:NP_001364618.1 Gene:col-78 / 189274 WormBaseID:WBGene00000654 Length:328 Species:Caenorhabditis elegans


Alignment Length:225 Identity:91/225 - (40%)
Similarity:101/225 - (44%) Gaps:58/225 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   381 RGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKG---------------GPGPRGPKGEPGRRGDPG 430
            :||.||.|.|||.|..||.|.|||||..|...               .|              ||
 Worm   138 QGPSGEKGDKGSDGRDGNDGYPGSPGKSGQDALERMITDGYIDFCFECP--------------PG 188

Human   431 TKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDA 495
            ..||||..|.||.:|..||.|.:|..|:          .||||.||.   |.|||.||.|.|   
 Worm   189 APGSPGEVGHKGPEGVLGPSGKKGKTGQ----------SLPGPVGPP---GPPGKDGSIGAP--- 237

Human   496 GPRGDSGQ----PGPKGDPGRPGFSYPGPRGAPGEKGEPGPRGPEGGRGDFGLKGEPGRKGEKGE 556
            ||.|.||:    .||   ||.||  .||..|.||..|:|||.||:|..|..|..|:||:.|..|.
 Worm   238 GPDGASGKILTMEGP---PGLPG--VPGSVGLPGIPGKPGPSGPDGKIGATGPGGDPGKPGGNGI 297

Human   557 PADPGPPGEPGPRGPRG----VPGPEGEPG 582
            |.:|||.|..||||..|    .|.....||
 Worm   298 PGEPGPIGNQGPRGSDGSCEHCPPARTPPG 327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
COL6A2NP_001840.3 Nonhelical region 21..256
vWA_collagen_alpha_1-VI-type 43..231 CDD:238757
gly_rich_SclB <255..>513 CDD:468478 57/150 (38%)
Triple-helical region 257..590 91/225 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..588 91/225 (40%)
Cell attachment site. /evidence=ECO:0000255 366..368
Cell attachment site. /evidence=ECO:0000255 426..428 0/1 (0%)
Collagen 487..556 CDD:460189 33/72 (46%)
Cell attachment site. /evidence=ECO:0000255 489..491 0/1 (0%)
Cell attachment site. /evidence=ECO:0000255 498..500 0/1 (0%)
Cell attachment site. /evidence=ECO:0000255 539..541 0/1 (0%)
Nonhelical region 591..1019
vWA_collagen_alpha_1-VI-type 612..803 CDD:238757
VWA 833..1007 CDD:459670
col-78NP_001364618.1 gly_rich_SclB <138..>314 CDD:468478 87/210 (41%)
Blue background indicates that the domain is not in the aligned region.

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