Protein Alignment COL6A2 and col-133

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: NP_502700.1
• Gene: col-133 / 186083
• WormBaseID: WBGene00000707
• Length: 304
• Species: Caenorhabditis elegans
• Alignment Length: 307
• Identity: 110/307 - (35%)
• Similarity: 134/307 - (43%)
• Gaps: 78/307 - (25%)

Human   231 INRIIKVMKHEAYGECYKVSCLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIG 295
            ||..||..||.|.....:|:.:.    |.||  ...:.|:          |.|..||.|:
 Worm    46 INHEIKFCKHSARDIFAEVNHIR----SSPK--NASRFAR----------QAGYGGDEGV----- 89

Human   296 FPGPKGVPGFKGEKGEFGADGRKGA----PGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRG-PDG 355
                        ::|..||.|...:    ||.||..||.|:.|:.||   ||..|.|||.| |..
 Worm    90 ------------DQGSEGAQGGSCSGCCLPGAAGPAGTPGKPGRPGR---PGAAGLPGNPGRPPA 139

Human   356 YPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPK 420
            .|.|..:|          .|.:|..:||   .||.|:.|.||::||||:||.....|.|||.|||
 Worm   140 QPCEPITP----------PPCKPCPQGP---AGAPGAPGPQGDAGAPGAPGQGSGAGAPGPAGPK 191

Human   421 GEPGRRGDPGTKGSPGSDGPKGEK----GDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALG 481
            |..|..|:||..|:||..|...:.    |.||..||:                  ||.||.|:.|
 Worm   192 GASGAPGNPGQAGAPGQPGADAQSESIPGAPGQAGPQ------------------GPPGPAGSPG 238

Human   482 EPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGAPGEKG 528
            .||..|..|.||..||.|..||||..|:||.||  .||..|..||||
 Worm   239 APGGPGQPGAPGQKGPSGAPGQPGADGNPGAPG--QPGQAGGAGEKG 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256		8/24 (33%)
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757	110/307 (36%)
		gly_rich_SclB	<255..>513	CDD:468478	93/266 (35%)
		Triple-helical region	257..590		102/281 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		102/281 (36%)
		Cell attachment site. /evidence=ECO:0000255	366..368		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	426..428		0/1 (0%)
		Collagen	487..556	CDD:460189	23/42 (55%)
		Cell attachment site. /evidence=ECO:0000255	489..491		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	539..541
		Nonhelical region	591..1019
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757
		VWA	833..1007	CDD:459670
col-133	NP_502700.1	Col_cuticle_N	12..64	CDD:198156	7/17 (41%)
		PRK07764	<89..281	CDD:236090	89/244 (36%)