Protein Alignment COL6A2 and col-102

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: NP_499957.1
• Gene: col-102 / 182802
• WormBaseID: WBGene00000676
• Length: 460
• Species: Caenorhabditis elegans
• Alignment Length: 371
• Identity: 124/371 - (33%)
• Similarity: 138/371 - (37%)
• Gaps: 81/371 - (21%)

Human   257 PSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPG-------------IEGPIGFPGPKGVPGFKGE 308
            |:||.|..|:.|..   ||||..|:.|..|.||             |:.|.|.|||   ||.:|.
 Worm    93 PAGPPGAAGEDGTP---GEPGTDGEDGGNGMPGVAQMAMDANGGACIKCPAGEPGP---PGPEGP 151

Human   309 KGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGK- 372
            .|..|..|..||.|.||..            ||.|..|.||..||||.||.|||.||.|..|.|
 Worm   152 AGPAGPAGNAGADGEAGAE------------GPAGEAGPPGPPGPDGKPGAAGSDGEAGAPGTKT 204

Human   373 -GDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPG 436
             ..||.||..|||               |.||..|..||..||||.||.|.||..|..|..|:||
 Worm   205 TNAPGEPGPAGPP---------------GPPGPNGEAGAGSGPGPEGPAGPPGPNGKDGEAGAPG 254

Human   437 SDGPKGEKGDPG------PEGPR----GLAGEVGNKGAKGDRGLPGPR-GPQGALGEPGKQGSRG 490
            .||..|..|.||      |..||    |..|.....||..:.....|. .|:.|....|..|...
 Worm   255 KDGDAGADGAPGTDAAYCPCPPRSAALGAGGGAEPAGAAPEAAAAAPEAAPEAAPAAEGAGGGAE 319

Human   491 DPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGAPGEKGEPGPRGPEGGRGDFG--------LKGE 547
            ..|.|.|  |:....|:..|.         ..||..:|..|...|.|...|..        .:..
 Worm   320 PAGAAAP--DAAAAAPEAAPA---------EAAPAAEGAGGGAEPAGAAPDAAAAAPEAAPAEAA 373

Human   548 PGRKGEKG--EPADPGPPGEPGPRGPRGVPGPEGEPGPPGDPGLTE 591
            |..:|..|  |||....| :.....|.....||..|...|..|..|
 Worm   374 PAAEGAGGGAEPAGAAAP-DAAAAAPEAAAAPEAAPAAEGAGGGAE 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757
		gly_rich_SclB	<255..>513	CDD:468478	103/281 (37%)
		Triple-helical region	257..590		123/368 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		122/366 (33%)
		Cell attachment site. /evidence=ECO:0000255	366..368		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	426..428		0/1 (0%)
		Collagen	487..556	CDD:460189	17/78 (22%)
		Cell attachment site. /evidence=ECO:0000255	489..491		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	539..541		0/1 (0%)
		Nonhelical region	591..1019		1/1 (100%)
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757
		VWA	833..1007	CDD:459670
col-102	NP_499957.1	Col_cuticle_N	5..56	CDD:198156
		gly_rich_SclB	<93..>268	CDD:468478	85/207 (41%)