Protein Alignment COL6A2 and col-41

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: NP_510522.1
• Gene: col-41 / 181610
• WormBaseID: WBGene00000618
• Length: 428
• Species: Caenorhabditis elegans
• Alignment Length: 333
• Identity: 116/333 - (34%)
• Similarity: 140/333 - (42%)
• Gaps: 55/333 - (16%)

Human   287 DPGIEG-PIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGC----KG 346
            |...:| |.|.|||.|.||.:|::|..|.:||:||.|::.....|         .|.||    :|
 Worm    87 DSNSQGCPAGAPGPPGNPGKRGDEGHPGDEGRRGASGISLATTHD---------IPGGCIKCPEG 142

Human   347 DPGNRGPDGYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAK 411
            ..|..||||..|..|.||.:|..|..|:.|.||:.|.||:.|.:|.|||.|..|..|.||....
 Worm   143 PAGPPGPDGDSGPEGFPGLQGQSGPSGEDGAPGQEGAPGDQGEQGPKGYDGTDGPDGQPGTTYF- 206

Human   412 GGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGP 476
              ||..|..||||..|:||..|.      .||.|..|.|||:|..|..||.|.....|.||..|.
 Worm   207 --PGQAGQPGEPGWLGEPGLPGQ------HGEPGKDGEEGPQGAPGTPGNAGHDAFPGTPGQAGK 263

Human   477 QGALGE-------PGKQGSRGDP--GDAGPRGDSGQPGPKGDPGRPGF-SYPGPRGAPGEKGEPG 531
            .||.|:       |.:|..|..|  |.:.|     ||.|:|....||. :.|..|..|..:..|.
 Worm   264 PGAPGKDANYCPCPQRQDDRTPPSSGTSAP-----QPPPRGSTAAPGTRAPPATRAPPATRAPPA 323

Human   532 -PRGPEGGRGDFGLKGEPGRKGE----------KGEPADPGP----PGEPGPRGPR-GVPGPE-G 579
             .|.|............|.|:.|          ..|||.|.|    |..|.|..|. ..|.|. .
 Worm   324 TTRAPPATTRPAPASQPPVREPETPDSGYPSPAPQEPAHPSPSYPSPSYPSPSYPSPSYPSPSYP 388

Human   580 EPGPPGDP 587
            .|..|.:|
 Worm   389 SPSYPAEP 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757
		gly_rich_SclB	<255..>513	CDD:468478	91/239 (38%)
		Triple-helical region	257..590		116/333 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		116/333 (35%)
		Cell attachment site. /evidence=ECO:0000255	366..368		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	426..428		0/1 (0%)
		Collagen	487..556	CDD:460189	19/82 (23%)
		Cell attachment site. /evidence=ECO:0000255	489..491		1/1 (100%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	539..541		0/1 (0%)
		Nonhelical region	591..1019
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757
		VWA	833..1007	CDD:459670
col-41	NP_510522.1	Col_cuticle_N	3..55	CDD:198156
		gly_rich_SclB	<130..>289	CDD:468478	67/176 (38%)
		PRK12323	<236..424	CDD:481241	50/166 (30%)