Protein Alignment COL6A2 and col-181

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: NP_001041295.1
• Gene: col-181 / 181378
• WormBaseID: WBGene00000754
• Length: 332
• Species: Caenorhabditis elegans
• Alignment Length: 352
• Identity: 111/352 - (31%)
• Similarity: 135/352 - (38%)
• Gaps: 123/352 - (34%)

Human   228 QDTINRIIKVMKHEAYGECYKVSCLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEG 292
            ||.:| ..:|......||..|::.:..|        |..:.|:|.....|
 Worm   100 QDEVN-FCRVRATSLEGELAKLNVVRAP--------RKARAAEGTCCSCG--------------- 140

Human   293 PIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPG---CKGDPGNRGPD 354
             :|..||.|.|||.|..|:.|::||.|.||    ...||...|     |..   |...|  ..|.
 Worm   141 -VGSAGPPGPPGFDGSAGKDGSNGRPGNPG----EDADGDDYK-----PDASQFCFDCP--EAPA 193

Human   355 GYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGP 419
            |.||.   ||..|:.||.|:|||.|..|.|                        ||:|.||||||
 Worm   194 GPPGR---PGPDGENGGAGEPGRDGLAGRP------------------------GARGSPGPRGP 231

Human   420 KGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPG 484
                        .|:||:|||.|:.   ||:|              |....|.|.|..||   ||
 Worm   232 ------------SGNPGADGPAGQL---GPQG--------------GSNVAPSPAGEPGA---PG 264

Human   485 KQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGAPGEKGEPGPRGPEGGRGDFGLKGEPG 549
            .||.:|.||.||..|..|||                 ||||::||.||.|..|..|..|..|.||
 Worm   265 AQGPKGPPGAAGRPGRDGQP-----------------GAPGDQGENGPDGAPGKSGSDGQPGAPG 312

Human   550 RKGEKGEPADPGPPGEPGPRGPRGVPG 576
            ::|.:| ..|..||       ||..||
 Worm   313 KEGSRG-GCDHCPP-------PRTAPG 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256		7/27 (26%)
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757	2/2 (100%)
		gly_rich_SclB	<255..>513	CDD:468478	80/260 (31%)
		Triple-helical region	257..590		103/323 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		103/323 (32%)
		Cell attachment site. /evidence=ECO:0000255	366..368		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	426..428		0/1 (0%)
		Collagen	487..556	CDD:460189	26/68 (38%)
		Cell attachment site. /evidence=ECO:0000255	489..491		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	539..541		0/1 (0%)
		Nonhelical region	591..1019
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757
		VWA	833..1007	CDD:459670
col-181	NP_001041295.1	Col_cuticle_N	65..117	CDD:198156	5/17 (29%)
		gly_rich_SclB	<156..>318	CDD:468478	83/248 (33%)