Protein Alignment COL6A2 and col-19

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: NP_001033577.1
• Gene: col-19 / 180397
• WormBaseID: WBGene00000608
• Length: 289
• Species: Caenorhabditis elegans
• Alignment Length: 322
• Identity: 111/322 - (34%)
• Similarity: 135/322 - (41%)
• Gaps: 100/322 - (31%)

Human   226 IDQDTINRIIKVMKHEAYGECYKVSCLEIPGPSG----PKGYRGQKGAKGNMGEPGEPGQKGRQG 286
            |.|||..|:  |.||              ..|:|    |..:....||:    ...:.|.:....
 Worm    47 ITQDTWARM--VSKH--------------INPTGHTNAPPTFETLFGAR----TARQAGFEQCNC 91

Human   287 DPGIEG-PIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGC----KG 346
            .|..|| |.|.|||.|..|.||..|..|.||:.||||:......|         .|.||    .|
 Worm    92 GPKSEGCPAGPPGPPGEGGQKGNPGHDGDDGKPGAPGVIVAITHD---------IPGGCIKCPPG 147

Human   347 DPGNRGPDGYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAK 411
            .||.:||.|.||.||..|..            |||||||.:|..|.:|.||::|.|      ||.
 Worm   148 RPGPKGPSGLPGSAGPAGGN------------GRRGPPGPVGGPGEQGPQGDAGRP------GAA 194

Human   412 GGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGP 476
            |.|||.||:||||....|            |:.|.|||:||||..|..||.||.
 Worm   195 GRPGPAGPRGEPGTEYKP------------GQPGRPGPQGPRGETGPAGNPGAP----------- 236

Human   477 QGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGAPGEKGEPGPRGPEGG 538
                         |:.|:||..|::|:|||.|        :||..|.||:|||....||:.|
 Worm   237 -------------GNDGEAGKNGNAGRPGPPG--------HPGKNGVPGQKGEDAAPGPDAG 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256		8/29 (28%)
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757	3/4 (75%)
		gly_rich_SclB	<255..>513	CDD:468478	92/266 (35%)
		Triple-helical region	257..590		103/291 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		103/291 (35%)
		Cell attachment site. /evidence=ECO:0000255	366..368		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	426..428		0/1 (0%)
		Collagen	487..556	CDD:460189	21/52 (40%)
		Cell attachment site. /evidence=ECO:0000255	489..491		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	539..541		111/322 (34%)
		Nonhelical region	591..1019
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757
		VWA	833..1007	CDD:459670
col-19	NP_001033577.1	Col_cuticle_N	4..55	CDD:198156	4/7 (57%)
		gly_rich_SclB	<77..>275	CDD:468478	98/272 (36%)