DRSC/TRiP Functional Genomics Resources

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Protein Alignment COL6A2 and col-143

DIOPT Version :10

Sequence 1:NP_001840.3 Gene:COL6A2 / 1292 HGNCID:2212 Length:1019 Species:Homo sapiens
Sequence 2:NP_504738.1 Gene:col-143 / 179073 WormBaseID:WBGene00000716 Length:319 Species:Caenorhabditis elegans


Alignment Length:219 Identity:93/219 - (42%)
Similarity:115/219 - (52%) Gaps:34/219 - (15%)


- Green bases have known domain annotations that are detailed below.


Human   319 GAPGLAGKNGTD-----GQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKGDP--G 376
            |:..|.|:|...     |::.:....||||..|.||.||..|.||.||.||    .|.:.:|  |
 Worm    66 GSSFLLGRNKRQAECNCGEQSRGCPAGPPGPPGQPGARGEAGLPGIAGQPG----SGARINPATG 126

Human   377 RPG-----RRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPG 436
            |||     ..|.||..|..|:.|.:||:|.||:|...|.:|.||||||.|:.|..|.||..||||
 Worm   127 RPGFCITCPAGAPGPAGPPGAPGPKGNNGQPGAPAQSGGRGPPGPRGPAGDAGSPGQPGHPGSPG 191

Human   437 SDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDS 501
            :.|..|::                ::|..|..|.|||:||.||.|:||:.|..|.||..||.|.|
 Worm   192 NPGRGGQR----------------SRGTPGASGRPGPQGPAGAPGQPGRSGGAGTPGPQGPPGPS 240

Human   502 GQPGPKGDPGRPGFSYPGPRGAPG 525
            ||||..|:.|.||  .||..||||
 Worm   241 GQPGHSGNDGVPG--TPGNPGAPG 262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
COL6A2NP_001840.3 Nonhelical region 21..256
vWA_collagen_alpha_1-VI-type 43..231 CDD:238757
gly_rich_SclB <255..>513 CDD:468478 85/205 (41%)
Triple-helical region 257..590 93/219 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..588 93/219 (42%)
Cell attachment site. /evidence=ECO:0000255 366..368 0/1 (0%)
Cell attachment site. /evidence=ECO:0000255 426..428 0/1 (0%)
Collagen 487..556 CDD:460189 22/39 (56%)
Cell attachment site. /evidence=ECO:0000255 489..491 0/1 (0%)
Cell attachment site. /evidence=ECO:0000255 498..500 0/1 (0%)
Cell attachment site. /evidence=ECO:0000255 539..541
Nonhelical region 591..1019
vWA_collagen_alpha_1-VI-type 612..803 CDD:238757
VWA 833..1007 CDD:459670
col-143NP_504738.1 Col_cuticle_N 5..57 CDD:198156
gly_rich_SclB <105..>264 CDD:468478 79/180 (44%)
Blue background indicates that the domain is not in the aligned region.

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