Protein Alignment COL6A2 and col-2

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: NP_501829.1
• Gene: col-2 / 177872
• WormBaseID: WBGene00000593
• Length: 301
• Species: Caenorhabditis elegans
• Alignment Length: 313
• Identity: 112/313 - (35%)
• Similarity: 128/313 - (40%)
• Gaps: 89/313 - (28%)

Human   318 KGAPG----LAGKNGTDGQKGKLGRIGPPGCKG--DPGNRGPDGYPGEAGSPGERGDQGGKGDPG 376
            |.|||    :|.:..:.|..|..|..|..||.|  :||..||.|.||:               ||
 Worm    68 KDAPGNNTRVARQAYSTGGAGGGGGGGGGGCDGCCNPGPPGPGGSPGK---------------PG 117

Human   377 RPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPK 441
            :||:.|.|               ||||:||    ||...|..|..:|..:..||  |.||..||.
 Worm   118 KPGKPGAP---------------GAPGNPG----KGASAPCEPVTQPPCQPCPG--GPPGPAGPA 161

Human   442 GEKGDPGPEG-PRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPG 505
            |..|.|||:| |...||..|          |||.||               ||.|||.|:.|.||
 Worm   162 GPPGPPGPDGNPGSPAGPSG----------PGPAGP---------------PGPAGPAGNDGAPG 201

Human   506 PKGDPGRPGFSYPGPRGAPGEKGEPGPRGPEGGRGDFGLKGEPGRKGEKGEPADPGPPGEPGPRG 570
            ..|.||.||.|..|..|.||..|.|||.||.|..|..| .|.||..|.||   .||..|.||..|
 Worm   202 APGGPGEPGASEQGGPGEPGPAGPPGPAGPAGNDGAPG-TGGPGPAGPKG---PPGAAGAPGADG 262

Human   571 PRGVPGPEGEPGPPGDPGLTECDVMTYVRETCGCCDCEKRCGALDVVFVIDSS 623
            ..|.||..|:||..|:.|:                 |.|.|.....||..|.:
 Worm   263 NPGGPGTAGKPGGEGEKGI-----------------CPKYCAIDGGVFFEDGT 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757
		gly_rich_SclB	<255..>513	CDD:468478	70/201 (35%)
		Triple-helical region	257..590		106/278 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		105/276 (38%)
		Cell attachment site. /evidence=ECO:0000255	366..368		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	426..428		0/1 (0%)
		Collagen	487..556	CDD:460189	33/68 (49%)
		Cell attachment site. /evidence=ECO:0000255	489..491		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	539..541		0/1 (0%)
		Nonhelical region	591..1019		6/33 (18%)
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757	3/12 (25%)
		VWA	833..1007	CDD:459670
col-2	NP_501829.1	Col_cuticle_N	<30..64	CDD:198156