Protein Alignment COL6A2 and col-101

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: NP_499905.2
• Gene: col-101 / 176854
• WormBaseID: WBGene00000675
• Length: 327
• Species: Caenorhabditis elegans
• Alignment Length: 304
• Identity: 104/304 - (34%)
• Similarity: 129/304 - (42%)
• Gaps: 91/304 - (29%)

Human   300 KGVPGFKGE------KGEFGADGRKGAPGLAGKNG--TDGQKGKLGRIGPPGCKGDPGNRGPDGY 356
            :||.|.:|.      :.::.|..|:.:.|.:|.:|  :.|..|     |...|....|:.||.|.
 Worm    87 EGVAGVEGRIKRNVYERKYHAKQRRQSYGDSGASGGFSSGGSG-----GGSCCSCGVGSAGPAGS 146

Human   357 PGEAGSPGERGDQGGKGDPGRPGR---------------RGPPGEIGAKGSKGYQGNSGAPGSPG 406
            ||:.|:||..|..|..|:||:..:               .||||..||.|.|   |.|||||.||
 Worm   147 PGQDGAPGNDGAPGAPGNPGQDAQDNQPAGPDSFCFDCPAGPPGPSGAPGQK---GPSGAPGQPG 208

Human   407 VKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGE----KGDPGPEGPRGLAGEVGNKGAKGD 467
            ..|....|||.||.|.||..|.||:.|:.|:.|..|.    .|.|||.||
 Worm   209 RSGGASLPGPPGPAGPPGPSGQPGSNGNAGAPGAPGHVVDVPGTPGPAGP--------------- 258

Human   468 RGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGAPGEKGEPGP 532
               |||.||.||.|:||:.|          ....|||||:||.|.||    .| |.||..|:||.
 Worm   259 ---PGPAGPAGAPGQPGQAG----------HAQPGQPGPQGDAGAPG----AP-GQPGSAGQPGN 305

Human   533 RGPEGGRGDFGLKGEPGRKGEKGEPADPGPPGEPGPRGPRGVPG 576
            .|.:||:|                ..|..||       ||..||
 Worm   306 DGGDGGQG----------------ACDHCPP-------PRTAPG 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757
		gly_rich_SclB	<255..>513	CDD:468478	84/239 (35%)
		Triple-helical region	257..590		104/304 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		104/304 (34%)
		Cell attachment site. /evidence=ECO:0000255	366..368		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	426..428		0/1 (0%)
		Collagen	487..556	CDD:460189	22/68 (32%)
		Cell attachment site. /evidence=ECO:0000255	489..491		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	539..541		0/1 (0%)
		Nonhelical region	591..1019
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757
		VWA	833..1007	CDD:459670
col-101	NP_499905.2	Col_cuticle_N	31..83	CDD:198156
		gly_rich_SclB	<141..>300	CDD:468478	76/194 (39%)