Protein Alignment COL6A2 and col-8

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: NP_001370389.1
• Gene: col-8 / 175981
• WormBaseID: WBGene00000597
• Length: 294
• Species: Caenorhabditis elegans
• Alignment Length: 328
• Identity: 120/328 - (36%)
• Similarity: 142/328 - (43%)
• Gaps: 93/328 - (28%)

Human   213 RNDYATMLPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPG-------PSGPKGYRGQKGAK 270
            ::|:...:.:...|.:||..||  |.||            ..||       .|.|..:....|.:
 Worm    35 QSDFDDEMFEFRAITKDTWQRI--VTKH------------TYPGGVDEETIESHPPTFETLFGTR 85

Human   271 GNMGEPGEPGQKGRQG-------DPGIEG-PIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKN 327
                       |.||.       .|..|| |.|.|||.|..|..||.|..|.||:.||||:....
 Worm    86 -----------KARQAYPEQCNCGPKSEGCPAGPPGPPGEGGQSGEPGHDGDDGKPGAPGVIVAI 139

Human   328 GTDGQKGKLGRIGPPGC----KGDPGNRGPDGYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIG 388
            ..|         .|.||    .|.||.|||.|..|.||..|::            ||.||||..|
 Worm   140 THD---------IPGGCIKCPPGRPGPRGPSGLVGPAGPAGDQ------------GRHGPPGPTG 183

Human   389 AKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPR 453
            .:|..|.||::|.|      ||.|.|||.||:||||....|   |..|..||.|.:|.|||||..
 Worm   184 GQGGPGEQGDAGRP------GAAGRPGPPGPRGEPGTEYRP---GQAGRAGPPGPRGPPGPEGNP 239

Human   454 GLAGEVGNKGAKGDRGLPG-PRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGR---PG 514
            |.|||.||:|..|..|:|| |       |.|||.|:.|:.|  ||    |:|||  |.|.   ||
 Worm   240 GGAGEDGNQGPVGHPGVPGRP-------GIPGKSGTCGEHG--GP----GEPGP--DAGYCPCPG 289

Human   515 FSY 517
            .||
 Worm   290 RSY 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256		9/42 (21%)
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757	3/17 (18%)
		gly_rich_SclB	<255..>513	CDD:468478	107/280 (38%)
		Triple-helical region	257..590		109/277 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		109/277 (39%)
		Cell attachment site. /evidence=ECO:0000255	366..368		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	426..428		0/1 (0%)
		Collagen	487..556	CDD:460189	15/34 (44%)
		Cell attachment site. /evidence=ECO:0000255	489..491		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	539..541
		Nonhelical region	591..1019
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757
		VWA	833..1007	CDD:459670
col-8	NP_001370389.1	Col_cuticle_N	4..56	CDD:198156	4/20 (20%)