Protein Alignment COL6A2 and rol-6

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: NP_495858.1
• Gene: rol-6 / 174397
• WormBaseID: WBGene00004397
• Length: 348
• Species: Caenorhabditis elegans
• Alignment Length: 341
• Identity: 120/341 - (35%)
• Similarity: 148/341 - (43%)
• Gaps: 52/341 - (15%)

Human   185 IRLFAVAPNQNLKEQGLRDIASTPHEL------YRNDYATMLPDSTEIDQDTINRIIKVMKHEAY 243
            :.|||.|   :|..|    :::..:||      :|:....|..|..::...|.:..::..::..|
 Worm    20 VSLFAAA---SLYSQ----VSNIWNELDAEIANFRSLTEDMWVDMVKLGAGTASNRVRRQQYGGY 77

Human   244 GECYKVSCLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIG-FPG--------- 298
            |..........|.|.|  ||...:.|.......|.|....:...||...|.| ||.
 Worm    78 GATGVQPPAPTPNPYG--GYGASQPAPPEKFPDGIPNGGNQPKFPGGGFPDGPFPNGGGPRGGNQ 140

Human   299 ---------PKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPD 354
                     |.|..|.:||:|..|.||:.|.||..||:..|.|     ...|.||...|  :||.
 Worm   141 CQCTVENSCPPGPAGPEGEEGPDGHDGQDGVPGFDGKDAEDVQ-----NTPPTGCFTCP--QGPL 198

Human   355 GYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGP 419
            |..|..|:||.||.:|.:|.||||||.|.||..|..|..|..|:.|.||||   |.||..|.| |
 Worm   199 GPQGPNGAPGLRGMRGARGQPGRPGRDGNPGMPGDCGPPGAPGSDGKPGSP---GGKGDDGER-P 259

Human   420 KGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPG 484
            .|.||.||.||..|..|..||.|....||..||:|..|..|..||.|:   .||.||.||.|.||
 Worm   260 LGRPGPRGPPGEAGPEGPQGPTGRDAYPGQSGPQGEPGLQGYGGAAGE---DGPEGPPGAPGLPG 321

Human   485 KQGS----RGDPGDAG 496
            |...    .|..||||
 Worm   322 KDAEYCKCPGREGDAG 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256		14/76 (18%)
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757	11/51 (22%)
		gly_rich_SclB	<255..>513	CDD:468478	106/265 (40%)
		Triple-helical region	257..590		105/263 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		105/263 (40%)
		Cell attachment site. /evidence=ECO:0000255	366..368		1/1 (100%)
		Cell attachment site. /evidence=ECO:0000255	426..428		1/1 (100%)
		Collagen	487..556	CDD:460189	5/14 (36%)
		Cell attachment site. /evidence=ECO:0000255	489..491		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	498..500
		Cell attachment site. /evidence=ECO:0000255	539..541
		Nonhelical region	591..1019
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757
		VWA	833..1007	CDD:459670
rol-6	NP_495858.1	Col_cuticle_N	5..57	CDD:198156	10/43 (23%)
		gly_rich_SclB	<150..>338	CDD:468478	92/202 (46%)