DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment COL6A2 and col-76

DIOPT Version :10

Sequence 1:NP_001840.3 Gene:COL6A2 / 1292 HGNCID:2212 Length:1019 Species:Homo sapiens
Sequence 2:NP_495726.2 Gene:col-76 / 174320 WormBaseID:WBGene00000652 Length:499 Species:Caenorhabditis elegans


Alignment Length:510 Identity:133/510 - (26%)
Similarity:175/510 - (34%) Gaps:161/510 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   219 MLPDSTEIDQDTINRIIKVMKHE------AYGECYKVSCLEIPGPSGPKGYRGQKGAKGNMGEPG 277
            ||.|.....||:.: |.|.:..|      :||.         ..||.|.|    |......|:||
 Worm    43 MLTDLRNCHQDSTD-IWKQLSQENVRGKRSYGR---------DAPSIPMG----KCCSCQQGKPG 93

Human   278 EPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGR---- 338
            ..|.||..|.|                              |.|||.|.||.:|:.||...    
 Worm    94 PTGPKGPDGGP------------------------------GQPGLIGLNGRNGRNGKYVASEAH 128

Human   339 ---------IGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKG 394
                     :.|||..|.||.:||.|..|.||:.|:.|..|..|.||..|.||||||:|.:|.:|
 Worm   129 NEPACQKCPVAPPGPPGHPGRKGPRGTAGNAGTAGKNGIPGRMGPPGPAGVRGPPGELGMRGPQG 193

Human   395 YQGN------SGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPR 453
            ..|.      .|.||.||..|::|..|..|..|.||..|.|||:|..|..|.:|.:|.|||.|| 
 Worm   194 DPGKVLNGAPQGQPGRPGKVGSRGKAGHTGRDGRPGLEGTPGTRGVQGERGSRGARGPPGPPGP- 257

Human   454 GLAGEVGNKGA----KGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPG 514
              ||..|.||:    :.|..|     .||        |:...|.:..|.|:.....|.....:|.
 Worm   258 --AGSDGRKGSCAHCQSDDKL-----SQG--------GANRRPEETDPEGEFSNQQPASYEEQPP 307

Human   515 ------------FSYPGPRGAPGEKGEPGPRGPEGGRGDFGLKGEPGRKGEKGEPADPGPPGEPG 567
                        ::.| |...|..:..|              ..|| |:..|..|:.|.|..:..
 Worm   308 VITTTTTETAPVYTNP-PAHQPVHRSFP--------------SAEP-RQSHKNSPSVPVPQEQYN 356

Human   568 PRGPRGVPGPEGEPGPPGDPGLTECDVMTYVRETCGCCDCEKRCGALDVVFVIDSSESIGYTNFT 632
            ......:|.....|           |.:.:        ...|..|.:.|....|.||.       
 Worm   357 SANSEVIPKTINYP-----------DTINH--------QSYKHDGDVSVAGTTDDSED------- 395

Human   633 LEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIQLDDERIDSLSSF 687
                  :||:......::...|:|......|.:.:..            |.||||
 Worm   396 ------VNVIPAGQYSSRQYASKTNKIGKAVHFGYSN------------DQLSSF 432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
COL6A2NP_001840.3 Nonhelical region 21..256 10/42 (24%)
vWA_collagen_alpha_1-VI-type 43..231 CDD:238757 5/11 (45%)
gly_rich_SclB <255..>513 CDD:468478 92/280 (33%)
Triple-helical region 257..590 106/367 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..588 106/365 (29%)
Cell attachment site. /evidence=ECO:0000255 366..368 0/1 (0%)
Cell attachment site. /evidence=ECO:0000255 426..428 0/1 (0%)
Collagen 487..556 CDD:460189 14/80 (18%)
Cell attachment site. /evidence=ECO:0000255 489..491 0/1 (0%)
Cell attachment site. /evidence=ECO:0000255 498..500 0/1 (0%)
Cell attachment site. /evidence=ECO:0000255 539..541 0/1 (0%)
Nonhelical region 591..1019 17/97 (18%)
vWA_collagen_alpha_1-VI-type 612..803 CDD:238757 15/76 (20%)
VWA 833..1007 CDD:459670
col-76NP_495726.2 Col_cuticle_N 10..61 CDD:198156 7/18 (39%)
gly_rich_SclB <153..>263 CDD:468478 49/112 (44%)
SPT5 154..>402 CDD:444063 84/311 (27%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.