Protein Alignment COL6A2 and col-45

DIOPT Version :10

• Sequence 1: NP_001840.3
• Gene: COL6A2 / 1292
• HGNCID: 2212
• Length: 1019
• Species: Homo sapiens
• Sequence 2: NP_490679.1
• Gene: col-45 / 171605
• WormBaseID: WBGene00000622
• Length: 327
• Species: Caenorhabditis elegans
• Alignment Length: 447
• Identity: 135/447 - (30%)
• Similarity: 173/447 - (38%)
• Gaps: 166/447 - (37%)

Human   125 ISSFRRGTF------TDCALANMT------EQIRQDRSKGTVHFAVVITDGHVTGSPCGGIKLQA 177
            :..|||..|      |.|.||.:.      :.|::..|.       ::.|.|
 Worm    12 VGRFRRNAFSAVALSTSCILAIVVLTPIAYQAIQRIHSN-------LLNDAH------------- 56

Human   178 ERAREEGIRLFAVAPNQNLKEQGLRDIASTPHELYRNDYATMLPDSTEIDQDTINRIIKVMKHE- 241
                      |..|.|::|..:.::                 :..|...|::.:.|..:.:|..
 Worm    57 ----------FCQARNRDLWTETMK-----------------MARSRGRDEELVARTKRAVKGTW 94

Human   242 AYGECYKVSCLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFK 306
            .:|:       .||..|...  |.|:.|:...|..|.|..:.|:|.|   ||   ||..||.
 Worm    95 LFGQ-------YIPDRSSRN--RRQQYAEAAGGGGGAPHAECRRGPP---GP---PGDDGVD--- 141

Human   307 GEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGG 371
                  |.||:.|||      ||||:.|::                |.|       |.:.|.|.|
 Worm   142 ------GTDGKDGAP------GTDGKDGQV----------------PQG-------PADGGYQEG 171

Human   372 KGD----------PGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRR 426
            ..|          ||.||..|.||:   |||:||.|.||.||:||..|.||..||.||.|.||..
 Worm   172 PSDAVEACTRECPPGPPGPTGAPGD---KGSRGYPGESGEPGTPGSAGPKGNAGPAGPPGPPGYP 233

Human   427 GDPGTKGSPGS-------DGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPG 484
            |.||..|..|.       .||.|.:|:.||:||               .|.|||||..||.||
 Worm   234 GRPGETGDHGKTIAGEAPPGPPGRQGEMGPQGP---------------PGPPGPRGKDGAGGE-- 281

Human   485 KQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGAPGEKGE----PGPRGPEG 537
                :|.|      ||.|.|||.|.||:||  .|||.|:.||||.    |.||.|.|
 Worm   282 ----KGAP------GDQGNPGPYGKPGQPG--APGPDGSAGEKGGCDHCPPPRTPPG 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COL6A2	NP_001840.3	Nonhelical region	21..256		22/143 (15%)
		vWA_collagen_alpha_1-VI-type	43..231	CDD:238757	18/117 (15%)
		gly_rich_SclB	<255..>513	CDD:468478	98/274 (36%)
		Triple-helical region	257..590		112/302 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..588		112/302 (37%)
		Cell attachment site. /evidence=ECO:0000255	366..368		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	426..428		0/1 (0%)
		Collagen	487..556	CDD:460189	26/55 (47%)
		Cell attachment site. /evidence=ECO:0000255	489..491		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	539..541
		Nonhelical region	591..1019
		vWA_collagen_alpha_1-VI-type	612..803	CDD:238757
		VWA	833..1007	CDD:459670
col-45	NP_490679.1	Col_cuticle_N	19..68	CDD:198156	13/78 (17%)
		gly_rich_SclB	<204..>313	CDD:468478	59/137 (43%)