DRSC/TRiP Functional Genomics Resources

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Protein Alignment COL4A6 and Col4a1

DIOPT Version :9

Sequence 1:XP_006724680.1 Gene:COL4A6 / 1288 HGNCID:2208 Length:1708 Species:Homo sapiens
Sequence 2:NP_723044.1 Gene:Col4a1 / 33727 FlyBaseID:FBgn0000299 Length:1779 Species:Drosophila melanogaster


Alignment Length:1813 Identity:801/1813 - (44%)
Similarity:952/1813 - (52%) Gaps:264/1813 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    41 QCFPEKGARGRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGI 105
            :|..|||.||.|||:|..|..|..||.|..|.||.||::|.|   ||||.:||||..|.||..|.
  Fly    83 KCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDP---GPYGQRGDKGERGSPGLHGQ 144

Human   106 NGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQ---KGSKGDPVLAPGSF 167
            .|:||..|..|..|.||::|.:|..|..|.||.:|..|:.||.|..||   ||.||:|....|.:
  Fly   145 AGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDY 209

Human   168 -KGMKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLG--FQGEKGV 229
             ||.||:||..|..|:.||||.||..|..|.:||.|.:||.|..|..|..|....|  ..|..|:
  Fly   210 AKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGI 274

Human   230 KGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPKGFPGISGPPGFPGLGTTGEKGEKGEKG 294
            ||:.|.|..:.|...|..:  || |:|..|.|||||..|..|..||.     |.||..|:|||||
  Fly   275 KGEKGEPASSFPVKPTHTV--MG-PRGDMGQKGEPGLVGRKGEPGPE-----GDTGLDGQKGEKG 331

Human   295 IPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGD------IGLPGPDVFIDID 353
            :||.||.||..|:   .||||..|:||..|.|||||..|..||||:      .|.||        
  Fly   332 LPGGPGDRGRQGN---FGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPG-------- 385

Human   354 GAVISGNPGDP----GVPGLPGLKGDEGIQGLRGP---SGVPGLPALSGVPGALGPQGFPGLKGD 411
               :.|.||.|    |.||.||.||..|..|..||   :||.|||...|..|..|..|.||..|:
  Fly   386 ---LLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGN 447

Human   412 QGNPGRT-TIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNL----- 470
            :|.||:. ..|.|||.|..|..||.|.||||.||.:     ..::|.||. |.||.||:.     
  Fly   448 EGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQ-----KGDAGLPGY-GIQGSKGDAGIPGY 506

Human   471 -GLKGIKGDSGFCACDGGVP------NTGPPGEPGPPGPWGLIGLPGLKGARGDRG--------- 519
             ||||.||:.||.. :.|.|      ..|.||..|.||..|..|.||..|.:||.|         
  Fly   507 PGLKGSKGERGFKG-NAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKC 570

Human   520 ----SG--GAQGPAGAPGLVGPLGPSGPKGKKGEP------ILSTIQGMPGDRGDSGSQGFRGVI 572
                :|  |.:|.:|.||:.|..|..||.|::|.|      .::...|.||::|:.|..|..|..
  Fly   571 SSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGAT 635

Human   573 GEPGK---------------DGVPGLP------------GLPGLPGDGGQ-GFPGEKGLPGLPGE 609
            |||||               .|.||.|            ||||:||..|: ||.|||||.|.||.
  Fly   636 GEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGN 700

Human   610 KGHPGP------PGLPG---NGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGDCCCREVGKGDLD 665
            .|.||.      ||:||   .|.||..|..|..||||..|..|::|.|||   |...|       
  Fly   701 DGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGS---CALDE------- 755

Human   666 TERGITLPCIIPGSYGPSGFPGTPGFPGPKGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELP-G 729
                |.:|     :.|..|.||..|.|||.|..|.||..|..|..|:.|..|.||:    |.| |
  Fly   756 ----IKMP-----AKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGV----EGPRG 807

Human   730 FPGPRGEK---GLPGFPGLPGKDGLPGMIGSPGLPGSKGATGDIFGAENGAPGEQGLQGLTGHKG 791
            ..||||||   |..|.||.||||||.|:.|..|.||.:|..|.......|.||..||||..|.:|
  Fly   808 LNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRG 872

Human   792 FLGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGIS 856
            ..|..|.||..|..|.|      |:||..|.||..|:||..|..|..|..|.:|:.|.||.|||.
  Fly   873 PTGPIGFPGADGSVGYP------GDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGID 931

Human   857 GHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGN---PGLVGLKGSPGSPGVAGLPALSGPKGEKGS 918
            |..|:.|.:|:.|.||.:...|..|.:|.|||   .|..|:.|:||..|.||:|.:||.||:||:
  Fly   932 GVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGA 996

Human   919 VGFVGFPGIP----GLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNP---GPVGIPSPR 976
            .|..|..| |    |.||.||..|:||..|..|..|..|..|.|||||::|.|   ||.|:|   
  Fly   997 TGLTGNDG-PVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLP--- 1057

Human   977 RPMSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMG 1041
                     ||...:|..|.   |||.|.:|:.|..|.||.||..||||:  .|.|:.||||..|
  Fly  1058 ---------GDASEKGQKGE---PGPSGLRGDTGPAGTPGWPGEKGLPGL--AVHGRAGPPGEKG 1108

Human  1042 IRGLPGL---------KGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGS 1097
            .:|..|:         ||..|:.|..|.|||.||.|..|.||.||..||||          .:|:
  Fly  1109 DQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPG----------AAGA 1163

Human  1098 PGPKGQPGESGFKGTKGRDGLIGNIGFPGNKGEDGKVGVSGDVGLPGAPGFPGVAGMRGEPGLP- 1161
            ||..|.||:.|.||..|..||      ||.|||.|.||:.   |..||||..|..|:||:|||| 
  Fly  1164 PGAVGYPGDRGDKGEPGLSGL------PGLKGETGPVGLQ---GFTGAPGPKGERGIRGQPGLPA 1219

Human  1162 ------------GSSGHQGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVP 1214
                        |..|:.|..|..|..||.||.|..|..|..||.|.||..|        :.|:|
  Fly  1220 TVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASG--------LNGIP 1276

Human  1215 GPAGLPGPKGEKGYPGIGI----GAPGKPGLRGQKGDRGFPGLQGPAGLPGAPG----ISLPSLI 1271
            |..|..||:||.||||:.|    |.||:||..|::|..|.|||.|..||||..|    :.||..|
  Fly  1277 GAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPI 1341

Human  1272 AGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFP------GIPGPKGPKGDQGIPG 1330
             |..|..|..||.|..|:||..|.||.||   .:||||..||.      |..|.||.|||:|:.|
  Fly  1342 -GPAGSKGERGLAGSPGQPGQDGFPGAPG---LKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQG 1402

Human  1331 FSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGL---QGDPGQTPTAEAV 1392
            .|||||.:|.||..|.||..|..|.||.||:.||.|.||:.|..|:.||   :|:||..|     
  Fly  1403 PSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLP----- 1462

Human  1393 QVPPGPL---GLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLPG 1454
              ||||.   |.||.:|..|..|.||.:|.:|:||.:|..|..|..|.:|..|.||..||.|.||
  Fly  1463 --PPGPKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPG 1525

Human  1455 LQGPPGFEGAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQLWVGYSLLFVEGQE 1519
            .:|..|..|..||:|..|.|.........|..:.:|||||.||.|..|.::||.|||||:|:|.:
  Fly  1526 ERGYEGAIGLIGQKGEPGAPAPAALDYLTGILITRHSQSETVPACSAGHTELWTGYSLLYVDGND 1590

Human  1520 KAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVSQTQIPQYISR 1584
            .|||||||..|||:|||||:|.:.|..|.||:||.||||::||:|.|.||||||...:|.|||||
  Fly  1591 YAHNQDLGSPGSCVPRFSTLPVLSCGQNNVCNYASRNDKTFWLTTNAAIPMMPVENIEIRQYISR 1655

Human  1585 CSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATP 1649
            |.|||||:..||||||.|.:|.||.||..||||||||||||.|..||||:|.|||||||||||||
  Fly  1656 CVVCEAPANVIAVHSQTIEVPDCPNGWEGLWIGYSFLMHTAVGNGGGGQALQSPGSCLEDFRATP 1720

Human  1650 FIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVSETLKAGQLHTRVSRCQVCMKS 1707
            ||||:||:||||::....|||:..:|..|.| |.|..:|:|||:..:.|||||||||:
  Fly  1721 FIECNGAKGTCHFYETMTSFWMYNLESSQPF-ERPQQQTIKAGERQSHVSRCQVCMKN 1777

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
COL4A6XP_006724680.1 Collagen 359..416 CDD:189968 28/63 (44%)
Collagen 681..740 CDD:189968 29/62 (47%)
Collagen 800..859 CDD:189968 25/58 (43%)
Collagen 905..964 CDD:189968 30/62 (48%)
Collagen 1029..1088 CDD:189968 29/67 (43%)
Collagen 1150..1208 CDD:189968 26/70 (37%)
C4 1485..1589 CDD:279721 62/103 (60%)
C4 1593..1705 CDD:279721 71/111 (64%)
Col4a1NP_723044.1 Collagen 104..161 CDD:189968 29/59 (49%)
Collagen 322..380 CDD:189968 32/60 (53%)
Collagen 413..465 CDD:189968 22/51 (43%)
Collagen 499..561 CDD:189968 24/62 (39%)
Collagen 574..632 CDD:189968 19/57 (33%)
Collagen 657..714 CDD:189968 24/56 (43%)
Collagen 765..824 CDD:189968 29/62 (47%)
Collagen 854..911 CDD:189968 26/62 (42%)
Collagen 884..943 CDD:189968 27/64 (42%)
Collagen 923..982 CDD:189968 25/58 (43%)
Collagen 1028..1085 CDD:189968 26/71 (37%)
Collagen 1229..1287 CDD:189968 24/65 (37%)
Collagen 1318..1376 CDD:189968 28/61 (46%)
Collagen 1399..1458 CDD:189968 29/58 (50%)
Collagen 1477..1534 CDD:189968 24/56 (43%)
C4 1555..1662 CDD:128421 65/106 (61%)
C4 1663..1777 CDD:128421 73/114 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 164 1.000 Domainoid score I3938
eggNOG 1 0.900 - - E33208_3BAFZ
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1354 1.000 Inparanoid score I139
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41315at33208
OrthoFinder 1 1.000 - - FOG0000443
OrthoInspector 1 1.000 - - otm41900
orthoMCL 1 0.900 - - OOG6_100768
Panther 1 1.100 - - O PTHR24023
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2460
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.900

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