Protein Alignment PROKR2 and Lkr

DIOPT Version :10

• Sequence 1: NP_658986.1
• Gene: PROKR2 / 128674
• HGNCID: 15836
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_647968.3
• Gene: Lkr / 38622
• FlyBaseID: FBgn0035610
• Length: 542
• Species: Drosophila melanogaster
• Alignment Length: 383
• Identity: 100/383 - (26%)
• Similarity: 183/383 - (47%)
• Gaps: 46/383 - (12%)

Human    19 DHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIV--IGIALAGIMLVCGIGNFVFIAALTRY 81
            :..|.|.|        ||..|:|...:......|:||  :.|...||.:|..|||.:.|..:...
  Fly     7 EQESRLEF--------LPGAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATT 63

Human    82 KKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNAL 146
            :::|.:||:.|||||.:|.::.:.|.||:....:::  ||.....:|:...:::.:|:.||...|
  Fly    64 RQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQ--SWNLPWFMCSFCPFVQALSVNVSVFTL 126

Human   147 LAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAY-FATETVLFIVKSQEKI---- 206
            .||||||:.||::||:.|.....:.|:|..:||:::|.|:|.|. |..|.:....:...:.
  Fly   127 TAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVT 191

Human   207 --FCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPG-FQTEQIRKRLR 268
              ||......|.||....|.| :| |:::.|...::..|.:::..||....|| .|..:....|:
  Fly   192 RPFCMNKNLSDDQLQSFRYTL-VF-VQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLK 254

Human   269 CRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLT-AFYVVECIAMSNSMIN--- 329
            .::|.:.:|:.::..:.|||.|...:.|:....|.  :.:.|::: .::..:.:|||||..|
  Fly   255 NKKKVIKMLIIVVIIFGLCWLPLQLYNILYVTIPE--INDYHFISIVWFCCDWLAMSNSCYNPFI 317

Human   330 ----------------TVCFVTVKNNTMKYFKKMMLLHWRPSQ-RGSKSSADLDLRTN 370
                            ..||...| .:|...::...:|.|.|. |.:.:::.:.:|:|
  Fly   318 YGIYNEKFKREFNKRFAACFCKFK-TSMDAHERTFSMHTRASSIRSTYANSSMRIRSN 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PROKR2	NP_658986.1	7tmA_prokineticin-R	54..344	CDD:320332	86/319 (27%)
		TM helix 1	55..81	CDD:320332	9/27 (33%)
		TM helix 2	88..113	CDD:320332	11/24 (46%)
		TM helix 3	128..158	CDD:320332	12/29 (41%)
		TM helix 4	169..190	CDD:320332	7/20 (35%)
		TM helix 5	220..249	CDD:320332	6/28 (21%)
		TM helix 6	268..298	CDD:320332	7/29 (24%)
		TM helix 7	312..337	CDD:320332	8/44 (18%)
Lkr	NP_647968.3	7tmA_leucokinin-like	36..329	CDD:320515	80/298 (27%)
		TM helix 1	37..63	CDD:320515	8/25 (32%)
		TM helix 2	70..95	CDD:320515	11/24 (46%)
		TM helix 3	108..138	CDD:320515	12/29 (41%)
		TM helix 4	149..170	CDD:320515	7/20 (35%)
		TM helix 5	205..234	CDD:320515	7/30 (23%)
		TM helix 6	254..284	CDD:320515	7/29 (24%)
		TM helix 7	297..322	CDD:320515	6/24 (25%)