DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PROKR2 and Lkr

DIOPT Version :9

Sequence 1:	NP_658986.1	Gene:	PROKR2 / 128674	HGNCID:	15836	Length:	384	Species:	Homo sapiens
Sequence 2:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	383	Identity:	100/383 - (26%)
Similarity:	183/383 - (47%)	Gaps:	46/383 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    19 DHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIV--IGIALAGIMLVCGIGNFVFIAALTRY 81
            :..|.|.|        ||..|:|...:......|:||  :.|...||.:|..|||.:.|..:...
  Fly     7 EQESRLEF--------LPGAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATT 63

Human    82 KKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNAL 146
            :::|.:||:.|||||.:|.::.:.|.||:....:::  ||.....:|:...:::.:|:.||...|
  Fly    64 RQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQ--SWNLPWFMCSFCPFVQALSVNVSVFTL 126

Human   147 LAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAY-FATETVLFIVKSQEKI---- 206
            .||||||:.||::||:.|.....:.|:|..:||:::|.|:|.|. |..|.:....:...:.
  Fly   127 TAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVT 191

Human   207 --FCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPG-FQTEQIRKRLR 268
              ||......|.||....|.| :| |:::.|...::..|.:::..||....|| .|..:....|:
  Fly   192 RPFCMNKNLSDDQLQSFRYTL-VF-VQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLK 254

Human   269 CRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLT-AFYVVECIAMSNSMIN--- 329
            .::|.:.:|:.::..:.|||.|...:.|:....|.  :.:.|::: .::..:.:|||||..|
  Fly   255 NKKKVIKMLIIVVIIFGLCWLPLQLYNILYVTIPE--INDYHFISIVWFCCDWLAMSNSCYNPFI 317

Human   330 ----------------TVCFVTVKNNTMKYFKKMMLLHWRPSQ-RGSKSSADLDLRTN 370
                            ..||...| .:|...::...:|.|.|. |.:.:::.:.:|:|
  Fly   318 YGIYNEKFKREFNKRFAACFCKFK-TSMDAHERTFSMHTRASSIRSTYANSSMRIRSN 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PROKR2	NP_658986.1	7tm_4	66..>220	CDD:304433	50/160 (31%)
PROKR2	NP_658986.1	7tm_1	70..329	CDD:278431	74/267 (28%)
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	77/288 (27%)
		7tm_1	52..318	CDD:278431	75/271 (28%)
		PHA03216	467..>519	CDD:177558
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910