DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PROKR2 and npr-5

DIOPT Version :9

Sequence 1:	NP_658986.1	Gene:	PROKR2 / 128674	HGNCID:	15836	Length:	384	Species:	Homo sapiens
Sequence 2:	NP_001024265.1	Gene:	npr-5 / 190386	WormBaseID:	WBGene00021983	Length:	433	Species:	Caenorhabditis elegans

Alignment Length:	382	Identity:	95/382 - (24%)
Similarity:	164/382 - (42%)	Gaps:	73/382 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    60 LAGIMLVCGI-GNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEH 123
            |.|.:.|.|| ||...:.|:.|.|:|::..|:.:.||..:|.::.....|....|.:.:  .|..
Worm    61 LYGFLFVLGIFGNGGVLWAVARNKRLQSARNVFLLNLIFTDLILVFTAIPVTPWYAMTK--DWAF 123

Human   124 GHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPS 188
            |.|:|..|....:.|::|::.:|.||::|::|.|..|.|..::.:.|..:..|:|:||.||.:|.
Worm   124 GSVMCHLVPLSNSCSVFVTSWSLTAISLDKFLHINDPTKQPVSIRQALAITFLIWIVSTLINLPY 188

Human   189 AY-FATETVLFIVKSQEKIFCGQI-----WPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCY---- 243
            .. |......|.|:..|..:||..     |..:..  .|.|...:..::||.|:..:|.||
Worm   189 LMSFEHVDGSFYVQPGETPYCGHFCDEANWQSENS--RKIYGTTVMLLQFVVPMAVITYCYFKIL 251

Human   244 ARISRELWFKAVPGFQ--TEQIRKRLRCRRKTV-LVLMCILTAYVLCWAPFYGFTIVRDFFPTVF 305
            .::|:::..:.....|  |::.|.....|:|.| .:|:.::..::.||.|.....:|:|     |
Worm   252 QKVSKDMIIQNAQFCQSLTQKQRSDATSRKKKVNYILIAMVVTFIGCWLPLTLLNLVKD-----F 311

Human   306 VKEKHYLTA---FYVVEC--IAMSNSMINTVCFVTV----------------------------- 336
            .||..:|..   |:.:..  ||||..:.|.:.|..:
Worm   312 KKEPEWLKRQPFFWAINAHVIAMSLVVWNPLLFFWLTRKQKRSGLSKILNSTEIVSSFASRVSNS 376

Human   337 -------KNNTMKYFKKMMLLHWRPSQRGSKSSADLDLRT-------NG-VPTTEEV 378
                   :||..:..||.::|....|.. :.||..|.:||       || ..||.|:
Worm   377 IRRSTFRRNNIDRVRKKQVVLDCEGSSY-TTSSRPLLIRTDVQATLSNGSTSTTREM 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PROKR2	NP_658986.1	7tm_4	66..>220	CDD:304433	45/160 (28%)
PROKR2	NP_658986.1	7tm_1	70..329	CDD:278431	72/276 (26%)
npr-5	NP_001024265.1	7tmA_NPYR-like	56..347	CDD:320331	79/294 (27%)
		TM helix 1	58..82	CDD:320331	8/20 (40%)
		TM helix 2	91..113	CDD:320331	5/21 (24%)
		TM helix 3	129..151	CDD:320331	6/21 (29%)
		TM helix 4	172..188	CDD:320331	6/15 (40%)
		TM helix 5	225..248	CDD:320331	7/22 (32%)
		TM helix 6	282..307	CDD:320331	6/24 (25%)
		TM helix 7	323..347	CDD:320331	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910