DRSC/TRiP Functional Genomics Resources

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Protein Alignment PROKR2 and dop-2

DIOPT Version :9

Sequence 1:NP_658986.1 Gene:PROKR2 / 128674 HGNCID:15836 Length:384 Species:Homo sapiens
Sequence 2:NP_001256126.1 Gene:dop-2 / 179347 WormBaseID:WBGene00001053 Length:849 Species:Caenorhabditis elegans


Alignment Length:207 Identity:58/207 - (28%)
Similarity:96/207 - (46%) Gaps:44/207 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    57 GIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSW 121
            |::|..|.|:..:||.:.|.::.||:.|::..|.||..||::|.|||||..|:.:..||... .|
 Worm    41 GLSLIVIPLITLLGNLLVIISVLRYRALQSAINFLILGLAVADLLVAIIVMPYAVYVYVTNG-DW 104

Human   122 EHGHVLCASVNYLRTVSLYV------STNALLAIAI---DRYLAIVHPL---KPRMNYQTASFLI 174
            ..|:::|         .:|:      ||.::|.:|:   |||.|:..|:   :...|.:....||
 Worm   105 YLGNLMC---------DIYMASDVCCSTASILLLAVISFDRYRAVSLPIQYSRQSQNVKRVWTLI 160

Human   175 ALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLY----YKSYFLFIFG-VEFVG 234
            |::|:||:.:|.|                 .:|...:.|.|...|    |.:.|..:.. :.||.
 Worm   161 AVIWLVSLTLASP-----------------MVFGVNVRPPDANPYECRFYNAEFSILSSMISFVI 208

Human   235 PVVTMTLCYARI 246
            |...:...|.||
 Worm   209 PCFLVLFVYIRI 220

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PROKR2NP_658986.1 7tm_4 66..>220 CDD:304433 46/169 (27%)
7tm_1 70..329 CDD:278431 54/194 (28%)
dop-2NP_001256126.1 7tmA_D2-like_dopamine_R 38..>233 CDD:320181 58/207 (28%)
TM helix 1 40..64 CDD:320181 7/22 (32%)
TM helix 2 73..95 CDD:320181 12/21 (57%)
TM helix 3 112..134 CDD:320181 5/21 (24%)
TM helix 4 158..174 CDD:320181 8/32 (25%)
TM helix 5 195..218 CDD:320181 4/22 (18%)
7tm_GPCRs <745..828 CDD:421689
TM helix 6 751..781 CDD:410628
TM helix 7 796..821 CDD:410628
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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