Protein Alignment PROKR2 and Tre1

DIOPT Version :10

• Sequence 1: NP_658986.1
• Gene: PROKR2 / 128674
• HGNCID: 15836
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_001284901.1
• Gene: Tre1 / 140439
• FlyBaseID: FBgn0046687
• Length: 399
• Species: Drosophila melanogaster
• Alignment Length: 396
• Identity: 87/396 - (21%)
• Similarity: 154/396 - (38%)
• Gaps: 95/396 - (23%)

Human    30 YGDYDLPMDEDEDMTK-----TRTFFAA-----KIVIGIALAGIMLVCGIGNFVFIAALTRYKKL 84
            :.|.|:.|||....|:     :.|.|||     .:.||:          :||.:.:.||.:...:
  Fly    12 FQDADMQMDEPAAATQSIYPHSATLFAAISACVFVTIGV----------LGNLITLLALLKSPTI 66

Human    85 R-NLTNLLIANLAISDFLVAIICCPFEMDYYVVR--QLSWEHGHVLCASVNYLRTVSLYVSTNAL 146
            | :.|...:.:|:|||.|.    |.|.:....||  |.||..|..||.....:...::.||..::
  Fly    67 REHATTAFVISLSISDLLF----CSFSLPLTAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSM 127

Human   147 LAIAIDRYLAIV-HP-----LKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFI---VKS 202
            :.|.::||:.|. |.     .||:.    .:..:..||.||.|:.:|       .:|.|   :..
  Fly   128 VGITLNRYILIACHSRYSQIYKPKF----ITLQLLFVWAVSFLLLLP-------PILGIWGEMGL 181

Human   203 QEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYA-------------RISRELWFKA 254
            .|..|...|...:.:...|:  ||:.|  |:.|.:.:.:.|:             |........|
  Fly   182 DEATFSCTILKKEGRSIKKT--LFVIG--FLLPCLVIIVSYSCIYITVLHQKKKIRNHDNFQIAA 242

Human   255 VPG--------FQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHY 311
            ..|        :.|....::.|...:..::::.|...:::|:.|.....:|.|      .:...|
  Fly   243 AKGSSSSGGGSYMTTTCTRKAREDNRLTVMMVTIFLCFLVCFLPLMLANVVDD------ERNTSY 301

Human   312 LTAFYVVECIAMSNSMINTVCFVTVKNN--------TMKYFKKMMLL-HW------RPSQ--RGS 359
            .....:...:|.::|:||.:.:.....|        .:.|:|...|| .|      .||:  ..|
  Fly   302 PWLHIIASVMAWASSVINPIIYAASNRNYSESIFYFRVAYYKIFALLKFWGEPLSPMPSRNYHQS 366

Human   360 KSSADL 365
            |:|.:|
  Fly   367 KNSKEL 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PROKR2	NP_658986.1	7tmA_prokineticin-R	54..344	CDD:320332	66/330 (20%)
		TM helix 1	55..81	CDD:320332	6/25 (24%)
		TM helix 2	88..113	CDD:320332	8/24 (33%)
		TM helix 3	128..158	CDD:320332	6/29 (21%)
		TM helix 4	169..190	CDD:320332	6/20 (30%)
		TM helix 5	220..249	CDD:320332	8/41 (20%)
		TM helix 6	268..298	CDD:320332	4/29 (14%)
		TM helix 7	312..337	CDD:320332	4/24 (17%)
Tre1	NP_001284901.1	7tmA_GPR84-like	37..341	CDD:320338	69/338 (20%)
		TM helix 1	37..63	CDD:320338	9/35 (26%)
		TM helix 2	71..94	CDD:320338	8/26 (31%)
		TM helix 3	109..139	CDD:320338	6/29 (21%)
		TM helix 4	153..171	CDD:320338	6/24 (25%)
		TM helix 5	195..220	CDD:320338	7/28 (25%)
		TM helix 6	264..294	CDD:320338	4/29 (14%)
		TM helix 7	302..327	CDD:320338	4/24 (17%)