|
Human 1 MEVPEPTCPAPPARDQPAPTPGPPGAPGGQASPHLTLGPVLLPPEQGLAPPTVFLKALPIPLYHT 65
||..|||.|.|.|.||||..||.||..||||||.||||||:|||||||| |||||||||:|||||
Mouse 1 MEASEPTHPTPSATDQPASVPGIPGGLGGQASPRLTLGPVILPPEQGLA-PTVFLKALPVPLYHT 64
Human 66 VPPGGLQPRAPLVTGSLDGGNVPFILSPVLQPEGPGPTQVGKPAAPTLTVNIVGTLPVLSPGLGP 130
|||||||||||||||||:|.:|||||||:||||||..|||||||.|.|||||||||||||.|:|.
Mouse 65 VPPGGLQPRAPLVTGSLEGASVPFILSPLLQPEGPSATQVGKPATPALTVNIVGTLPVLSSGVGS 129
Human 131 TLGSPGKVRNAGKYLCPHCGRDCLKPSVLEKHIRSHTGERPFPCATCGIAFKTQSNLYKHRRTQT 195
.|.|.|:|:|.|||||||||||||||||||||||||||||||||.||||||||||||||||||||
Mouse 130 ALVSTGRVKNTGKYLCPHCGRDCLKPSVLEKHIRSHTGERPFPCPTCGIAFKTQSNLYKHRRTQT 194
Human 196 HLNNSRLSSESEGAGGGLLEEGDKAGEPPRPEGRGESRCQGMHEGASERPLSPGAHVPLLAKNLD 260
||||||||.||||:|..||||||:.||....:.||: |||.||.|||||...|.|:|.:
Mouse 195 HLNNSRLSLESEGSGSSLLEEGDRPGETASVDSRGD-------EGAPERALSPGALPALAAQNRE 252
Human 261 VRTEAAPCPGSAFADREAPWDSAPMASPGLPAASTQPWRKLPEQKSPTAGKPCALQRQQATAAEK 325
.:.|:||..|:..:.|||..|...|.||....||.||.|||||. |||.|||||.|.:||
Mouse 253 RKVESAPSLGATLSHREASADHTQMVSPEFSLASPQPRRKLPEP------KPCFLQRQQETCSEK 311
Human 326 PWDAKAPEGRLRKCESTDSGYLSRSDSAEQPHAPCSPLHSLSEHSAESEGEGGPGPGPGVAGAEP 390
|||.||.||:|||||||||||||||||.|||....||||||||||||||||||||.......||.
Mouse 312 PWDPKALEGQLRKCESTDSGYLSRSDSVEQPPVASSPLHSLSEHSAESEGEGGPGCSSSGNRAER 376
Human 391 GAREAGLELEKKRLEERIAQLISHNQAVVDDAQLDNVRPRKTGLSKQGSIDLPTPYTYKDSFHFD 455
|.....||||||:||||||||||||||||||.|||:||||||.||||||||||.|||||||||||
Mouse 377 GTPGPSLELEKKKLEERIAQLISHNQAVVDDPQLDHVRPRKTVLSKQGSIDLPMPYTYKDSFHFD 441
Human 456 IRALEPGRRRAP-GPVRSTWTPPDKSRPLFFHSVPTQLSTTVECVPVTRSNSLPFVEGSRTWLEP 519
||||||.||||. .|.|||:||.:|:|||||||||||||||||||||||||||||||||:.|.|.
Mouse 442 IRALEPSRRRAALSPARSTFTPLEKARPLFFHSVPTQLSTTVECVPVTRSNSLPFVEGSKLWPEQ 506
Human 520 REPRDPWSRTQKPLSPRPGPARLGCRSGLSSTDVPSGHPRALVRQAAVEDLPGTPIGDALVPAED 584
|:|:|.....||.|||||.|||||||.||:...:.|||||||||||||||||.||.||....||:
Mouse 507 RDPQDAVPGMQKALSPRPTPARLGCRPGLTLASISSGHPRALVRQAAVEDLPCTPTGDPSAAAEE 571
Human 585 TDAKRTAAREAMAGKGRAGGRKCGQRRLKMFSQEKWQVYGDETFKRIYQKMKASPHGGKKAREVG 649
.|.||..|:|.:..|||| .:||.||:.:|||||||||||:|||||||||||.:..||:|.|:|.
Mouse 572 LDGKRAVAKEGVVYKGRA-SKKCSQRKQRMFSQEKWQVYGNETFKRIYQKMKTNHQGGQKHRQVK 635
Human 650 MGSGAELGF----PLQKEAAGSSGTVPTQDRRTPVHEDISAGATPEPWGNPPALEASLVTEPTKH 710
.|.|.||.| |.||:..|...|..:||.|.|:..|.:||...|.||:.|:||.||..|..|.
Mouse 636 QGQGTELDFPPPPPPQKQGGGGEDTGLSQDSRIPILGDTTAGCKLESWGSRPSLEDSLEAESPKQ 700
Human 711 GETVARRGDSDRPRVEEAVSSPALGGRDSPCSGSRSPLVSPNGRLELGWQMPPAPGPLKGGDVEA 775
.:.|.| ..|||.||..||.|...:|.|:||:|:|:||.|.||.|...:.||:||
Mouse 701 LKVVTR-----------VKSSPTLGSTDSLCLSGKSSLLSPSGKLDLGCQPPPVPTACQAGDLEA 754
Human 776 PRPVWPDPKLEGGARGVGDVQETCLWAQTVLRWPSRGS-----GEDKLPSERKKLKVEDLHSWKQ 835
|....||...|. ::||...||||||..|.|| .|||||||||:||||.|...:|
Mouse 755 PETASPDSSGEA-------IKETSPGAQTVLRRSSDGSVALQLAEDKLPSERKRLKVEGLDHQEQ 812
Human 836 PEPVSAETPGGPTQPASLSSQKQDADPGEVPGGSKESARQVGEPLESSGASLAAASVALKRVGPR 900
|.|:.|:|.||..|.....|::||:|..|:.|.|.:|...|....|.|..|.||:.|||:..|..
Mouse 813 PGPLEADTSGGSVQADPPPSERQDSDSEELLGCSNKSTLHVTTAPEPSDVSSAASPVALQWPGIG 877
Human 901 DKATPLHPAAP-APAEHPSLATPPQAPRVLSALADNAFSPKYLLRLPQAETPLPLPIPWGPRHSQ 964
||.:|| |:.| .|..|..|...||.|.|.:|.:...|.|||||||||.|.|.|: :..||....
Mouse 878 DKDSPL-PSVPRTPGLHSLLPAQPQDPGVPNARSGGFFPPKYLLRLPQGENPSPI-VAAGPEKGS 940
Human 965 DSLCSSGWPEERASFVGSGLGTPLSPSPASGPSPGEADSILEDPSCSRPQDGRKGAQLGGDKGDR 1029
||||:|..|.|:|..|||.||....|...|| ||||....:|||.||.:||::.||.|.:|.||
Mouse 941 DSLCTSTQPVEQALLVGSELGMLRPPGAYSG--PGEAGGSPDDPSWSRLRDGKEEAQTGREKRDR 1003
Human 1030 MATSRPAARELPISAPGAPREATSSPPTPTCEAHLVQDMEGDSHRIHRLCMGSTLARARLSGDVL 1094
...:.......|:......:|..|...|.||:..:.||:...:|.||.||..|..||||..|::|
Mouse 1004 TKDNILVVGHSPVPITSTTQEIASVLSTHTCDIRVAQDVVSKTHAIHCLCTDSPPARARTYGNLL 1068
Human 1095 NPWVPNWELGEPPGNAPEDPSSGPLVGPDPCSPLQPGSFLTALTRPQGVPPGWPELALSSHSGTS 1159
|||..:.:||.||.:|.|.|.|....|.......|...|||..|:||.:.....:.|||...||.
Mouse 1069 NPWTSSQKLGIPPKSALEGPPSETKEGLPAFFSSQAHYFLTTFTKPQDISLNQQKPALSHVLGTP 1133
Human 1160 RSHSTRSPHSTQNPFPSLKAEPRLTWCCLSRSVPLPAEQKAKAASVYLAVHFPGSSLRDEGPNGP 1224
| |..:|.| |||||.||:|||||||||:||||||: :.|..:||...|..:|:.:.....
Mouse 1134 R--SCEAPSS----FPSLKTEPQLTWCCLSRSLPLPAEQR-RIAPGHLASSLPNRNLQGDSNKTL 1191
Human 1225 PGSNGGWTWTSPGEGGPAQMSKFSYPTVPGVMPQHQVSEPEWKKGLPWRAKM--SRGNSKQRKLK 1287
|.||||.|.||.|.....|..:..||:||.:..:.|||.|.|||...||.|: ||.|:||:||:
Mouse 1192 PKSNGGRTQTSQGGEVSTQAPELPYPSVPELRAEDQVSRPRWKKEQLWRRKVKTSRENTKQKKLR 1256
Human 1288 INPKRYKGNFLQSCVQLRASRLRTPTWVRRRSRHPPALEGLKPCRTPGQTSSEIA---------- 1342
::.||.:|:|.| ||.||..|.|:.|||..|..||||:|..|.|::|:|:|
Mouse 1257 LHSKRCEGSFWQ-----RAKRLCKPPWLPRRSCLPHRLEGLEPRGTLGRSSAEVAGNIFLGGESG 1316
Human 1343 -GLNLQEEPSCATSESPPCCGKEEKKEGDCRQTLGTLSLGTSSRIVREMDKRTVKDISPSAGEHG 1406
|.|:|.|||||:.:.....|.:| |||||.||...:|.|.||:.:.||||..:|||||:.|||.
Mouse 1317 LGRNVQGEPSCASKDLSVSHGNKE-KEGDCSQTSRPMSPGMSSKTMLEMDKSALKDISPTTGEHN 1380
Human 1407 DCTTHST-AATSGLSLQSDTCLAVVNDVPLPPGKGLDLGLLETQLLASQDSVSTDPKPYIFSDA- 1469
||:.... |..||||.||:|.|||..: .:|.|||||:|..||||..|||.||..|......|.
Mouse 1381 DCSQEKEHAGGSGLSPQSNTFLAVFQE-DVPQGKGLDVGPPETQLPPSQDQVSITPNLCFSPDVP 1444
Human 1470 QRPSSFGSKGTFPHHDIATSVAAVCISLPVRTDHIAQEIHSAESRDHSQTAGRTLTSSSPDSKVT 1534
:.||||..||||||||:||||||:|:|..:||.......||||| .|..||..:|||.:.|
Mouse 1445 ELPSSFKPKGTFPHHDVATSVAAICVSAGIRTGRKTLRAHSAES-----CAEETLARNSPDRRGT 1504
Human 1535 EEGRAQTLLPGRPSSGQRISDSVPLESTEKTHLEIPASGPSSASSHHKEGRHKTFFPSRGQYGCG 1599
.:...:.|||||||.|: :|..:| ||||:|||||.||..:|.|.:..||..||||||
Mouse 1505 PDSIPRVLLPGRPSPGK--------QSPGQT-LEIPSSGPSSVSSLQEEARAQADFPWWGQYGCG 1560
Human 1600 EMTVPCPSLGSDGRKRQVSGLITRKDSVVPSKPEQPIEIP-EAPSKSLKKRSLEGMRKQTRVEFS 1663
::||...:.||:.|..|..||||.|....||.|.||.::| |||.:|::||||||||||||||.|
Mouse 1561 DLTVQGAASGSESRTCQAEGLITSKTVTAPSDPGQPSQVPEEAPLRSIRKRSLEGMRKQTRVELS 1625
Human 1664 DTSSDDEDRLVIEI 1677
||||||||||||||
Mouse 1626 DTSSDDEDRLVIEI 1639
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