DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BHLHE23 and twi

DIOPT Version :9

Sequence 1:	NP_542173.2	Gene:	BHLHE23 / 128408	HGNCID:	16093	Length:	241	Species:	Homo sapiens
Sequence 2:	NP_001033967.1	Gene:	twi / 37655	FlyBaseID:	FBgn0003900	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	215	Identity:	64/215 - (29%)
Similarity:	89/215 - (41%)	Gaps:	53/215 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    26 DAYLALSHGYAAAAA--GLAYGAA--REPEAARGYGTPGPGGDLPA---APAPRAPAQAAES--S 81
            :||.....||..|.:  |.||.::  .:.|.|| :.......||..   :||..|...:|.|  .
  Fly   268 NAYRQSFEGYEPANSLNGSAYSSSDRDDMEYAR-HNALSSVSDLNGGVMSPACLADDGSAGSLLD 331

Human    82 GEQSGDEDDAFEQRRRRRGPGSAADGRRRPR------EQRSLRLSINARERRRMHDLNDALDGLR 140
            |..:|.:  ||.:.|||.        :|:|.      |..:.|:..|.|||:|...||||...|:
  Fly   332 GSDAGGK--AFRKPRRRL--------KRKPSKTEETDEFSNQRVMANVRERQRTQSLNDAFKSLQ 386

Human   141 AVIPYAHSPSVRKLSKIATLLLAKNYI--LMQAQALDEMRRLVAFLNQGQ----GLAAPV----- 194
            .:||...|.   |||||.||.||..||  |.:..:..::..|.|...||.    |.|:.:
  Fly   387 QIIPTLPSD---KLSKIQTLKLATRYIDFLCRMLSSSDISLLKALEAQGSPSAYGSASSLLSAAA 448

Human   195 -------------NAAPLTP 201
                         |.||:.|
  Fly   449 NGAEADLKCLRKANGAPIIP 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHE23	NP_542173.2	bHLH_SF	111..191	CDD:412148	33/91 (36%)
twi	NP_001033967.1	HLH	363..413	CDD:278439	25/52 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910