DRSC/TRiP Functional Genomics Resources

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Protein Alignment Col4a2 and Col4a1

DIOPT Version :9

Sequence 1:NP_034062.3 Gene:Col4a2 / 12827 MGIID:88455 Length:1707 Species:Mus musculus
Sequence 2:NP_723044.1 Gene:Col4a1 / 33727 FlyBaseID:FBgn0000299 Length:1779 Species:Drosophila melanogaster


Alignment Length:1885 Identity:798/1885 - (42%)
Similarity:960/1885 - (50%) Gaps:381/1885 - (20%)


- Green bases have known domain annotations that are detailed below.


Mouse    34 GVKKLDVPCGGRDCS---GGC--QCYPEKGARGQPGAVGPQGYNGPPGLQGFPGLQGRKGDKGER 93
            ||.:.|:|  .::|:   .||  :|..|||.||.||.:||.|..|.   .||||::|..||||::
  Fly    62 GVARGDLP--PKNCTAGYAGCVPKCIAEKGNRGLPGPLGPTGLKGE---MGFPGMEGPSGDKGQK 121

Mouse    94 GVPGPTGPKGDVGARGVSGFPGADGIPGHPGQGGPRGRPGYDGCNGTRGDAGPQGPSGSGGFPGL 158
            |.|||.|.:||.|.|   |.||..|..|.||..||.|.||..|.||..|..|..|..|..|..|:
  Fly   122 GDPGPYGQRGDKGER---GSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGM 183

Mouse   159 PGPQ------GPKGQKGEPYALSKEDRDKYRGEPGEP------GLVGYQGPPGRPGPIGQMGPMG 211
            |||:      |.||:||||   :||:.|..:||.|||      ||.|.||.||..|..|..||.|
  Fly   184 PGPRGYAGQLGSKGEKGEP---AKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYG 245

Mouse   212 APG-------------------RPGPPGPPGPKGQP-------------GNRGLGFYGQKGEKGD 244
            |.|                   :||.||..|.||:|             |.|  |..|||||.|.
  Fly   246 AKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPR--GDMGQKGEPGL 308

Mouse   245 I---GQPGPNGIPSDITLVGPTTSTIHPDLYKGEK------GDEGEQ---GIPGVISKGEEGIMG 297
            :   |:|||.|   |..|.|          .||||      ||.|.|   |.||  |.|::|..|
  Fly   309 VGRKGEPGPEG---DTGLDG----------QKGEKGLPGGPGDRGRQGNFGPPG--STGQKGDRG 358

Mouse   298 FPGIRGFPGLDGEKGVVGQKGSRGLDGFQGPSGPRGPKGERGEQGPPGPS-----VYSPHPSLAK 357
            .||:.|.||..|:||..|:.|:.|..|..||.||  |.|.||..|||||.     |.:|.|....
  Fly   359 EPGLNGLPGNPGQKGEPGRAGATGKPGLLGPPGP--PGGGRGTPGPPGPKGPRGYVGAPGPQGLN 421

Mouse   358 GARGDPGFQGAHGEPGSRGEPGEPGTAGPPGPSVGDEDSMRGLPGEMGPKGFSGEPGSPARYLGP 422
            |..|.||.||.:|:.|..|.||.||..||||..           ||.|..|.:|..||    :||
  Fly   422 GVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKK-----------GEKGTAGLNGPKGS----IGP 471

Mouse   423 PGADGRPGPQGVPGPAGPPGPDGFLFGLKGSEGRVGYPGPSGFPGTRGQKGWKGEA---GDCQCG 484
            .|..|.|||:|..|.||.||     :|::||:|..|.||..|..|::|::|:||.|   ||.:.|
  Fly   472 IGHPGPPGPEGQKGDAGLPG-----YGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLG 531

Mouse   485 Q-----VIG--------GLPGLPGPKGFPGVNGEL---------GKKGDQGDPGLHGIPGFPGFK 527
            :     ..|        |.||.||.||..|:.|::         |.|||:|..||.||||..|.:
  Fly   532 RPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGAR 596

Mouse   528 GAPGVAGAPGPK---GIKGDSRTITTKGERGQPGIPGVHG---------------MKGDDGVPGR 574
            |.||..|.||.:   ||.|.:.....|||.|:.|:||..|               :|||.|.||.
  Fly   597 GPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGA 661

Mouse   575 ---------DGLDGFPGLPGPPGD-------GIKGPPGDAGLPGVPGTKGFPGDIGPPGQGLP-- 621
                     .|.:|.||:|||.|:       |:.|.||:.|.||..|..|:||..|...:|.|  
  Fly   662 PGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGF 726

Mouse   622 -------------GPKGERGFPGDAGL-------------PGPPGFPGPPGPPGTPGQRDCDTGV 660
                         |..||:|.||...|             ||..|.|||||..|:||:|      
  Fly   727 HGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGER------ 785

Mouse   661 KRPIGGGQQVVVQPGCIEGPTGSPGQPGPPGPTGAKGVRGMPGFPGASGEQGLKGFPGDPGREGF 725
                              |.||..|..||.||.|.:|.||:.|..|..|.||..|.||:||::|.
  Fly   786 ------------------GYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGL 832

Mouse   726 PGPPGFMGPRGSKGTTGLPGPDGPPGPIGLPGPAGPPGDRGIPGEVLGAQPGTRGDAGLPGQPGL 790
                     ||..|..|.|||.|.|| |..|||.||||..|:.||        :||.|..|..|.
  Fly   833 ---------RGIPGRNGQPGPRGEPG-ISRPGPMGPPGLNGLQGE--------KGDRGPTGPIGF 879

Mouse   791 KGLPGETGAPGFRGSQGMPGM---PGLKGQPGFPGPSGQPGQSGPPGQHGFPGTPGREGPLGQPG 852
            .|..|..|.||.||..|:||:   ||:.|:.|..||.|..|.:||||..|..|..||:|..|:||
  Fly   880 PGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPG 944

Mouse   853 SPGLGGLP---GDRGEPGD------------PGVPGPVGMKGLSGDRGDAGMSGERGHPGSPGFK 902
            ||||.|:|   ||||.||:            ||..||.|:.|:||.:||.|.:|..|:.|..|.:
  Fly   945 SPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGR 1009

Mouse   903 GMAGMPGIPGQKGDR---GSPGMDGFQGMLGLKGRQGFPGTKGEAGFFGVPGLKGLPGEPGVKGN 964
            |..|.||:.|.|||:   |:||..|..||.|.||.|||||..|..|..|....||..||||..|.
  Fly  1010 GPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGL 1074

Mouse   965 RGDRGPPGPPPLILPGMKDI-----------KGEKGDEGPMGLKGYLGLKGIQGMPGVPGVSGFP 1018
            |||.||.|.|.  .||.|.:           .|||||:|..|:.|..|:.|.:|..|:.||.|.|
  Fly  1075 RGDTGPAGTPG--WPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQP 1137

Mouse  1019 GLPGRPGFIKGVKGDIGVPGTPGLPGFPGVSGPPGITGFPGFTGSRGEKGTPGVAGVFGETGPTG 1083
            |       .||..|..|:||.||:.|.||.:|.||..|:||..|.:||.|..|:.|:.|||||.|
  Fly  1138 G-------EKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVG 1195

Mouse  1084 DFGDIGDTVDLPGSPGLKGERGITGIPGL----------------KGFFGEKGAAGDIGFPGITG 1132
            ..|       ..|:||.||||||.|.|||                :|:.||||..|:.|..|..|
  Fly  1196 LQG-------FTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAG 1253

Mouse  1133 MAGAQGSPGLKGQTGFPGLTGLQGPQGEPGRIGIPGDKGDFGWPGV-----PGLPGFPGIRGISG 1192
            :|||:|..||:|..|..||.|:.|.:|:      .|.:|:.|:|||     .||||.||..|..|
  Fly  1254 VAGAKGDRGLQGPPGASGLNGIPGAKGD------IGPRGEIGYPGVTIKGEKGLPGRPGRNGRQG 1312

Mouse  1193 LHGLPGTKGFPGSPGVDAHGDPGFPGPTGDRGDRGEANTLPGPVGVPGQKGERGTPGERGPAGSP 1257
            |.|.||..|..|.||:  .|:||..|             ||||:|..|.|||||.      ||||
  Fly  1313 LIGAPGLIGERGLPGL--AGEPGLVG-------------LPGPIGPAGSKGERGL------AGSP 1356

Mouse  1258 GLQGFPGISPPSNISGSPGDVGAPGIFGLQGYQGPPGPPGPNALPGIKGDEGSSGAAGFPGQKGW 1322
                           |.||..|.||..||:|..||         .|.||:.|.:   ||.||||.
  Fly  1357 ---------------GQPGQDGFPGAPGLKGDTGP---------QGFKGERGLN---GFEGQKGD 1394

Mouse  1323 VGDPGPQGQPGVLGLPGEKGPKGEQGFMGNTGPSGAVGDR---GPKGPKGDQGFPGAPGSMGSPG 1384
            .||.|.||..|:.||.|:||..|..|..||.||.||.|:|   ||||..|..|.||.||..|.||
  Fly  1395 KGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPG 1459

Mouse  1385 I---PGIPQKIAVQPGTLGPQGRRGLPGALGEIGPQGPPGDPGFRGAPGKAGPQGRGGVSAVPGF 1446
            :   || |:....|||..||:|..|.||..|.||.||..|:.|.||..|:.|..||      ||.
  Fly  1460 MLPPPG-PKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGR------PGP 1517

Mouse  1447 RGDQGPMGHQGPVGQEGEPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYS 1511
            :||:|..|.:|..|..|..|:.|.||.|.........|.|:.:|||::..|.|..|..:||:|||
  Fly  1518 KGDRGEPGERGYEGAIGLIGQKGEPGAPAPAALDYLTGILITRHSQSETVPACSAGHTELWTGYS 1582

Mouse  1512 LLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEE 1576
            |||.:|.:.|||||||..|||:.||||:|.|.|...:||.|||||||::||:|.|.:|||||...
  Fly  1583 LLYVDGNDYAHNQDLGSPGSCVPRFSTLPVLSCGQNNVCNYASRNDKTFWLTTNAAIPMMPVENI 1647

Mouse  1577 EIKPYISRCSVCEAPAVAIAVHSQDTSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSC 1641
            ||:.|||||.||||||..||||||...:|.||.||..||||||||||||.|:.||||:|.|||||
  Fly  1648 EIRQYISRCVVCEAPANVIAVHSQTIEVPDCPNGWEGLWIGYSFLMHTAVGNGGGGQALQSPGSC 1712

Mouse  1642 LEDFRATPFIECNGGRGTCHYFANKYSFWLTTIPEQNFQSTPSADTLKAGLIRTHISRCQVCMKN 1706
            ||||||||||||||.:||||::....|||:..:........|...|:|||..::|:|||||||||
  Fly  1713 LEDFRATPFIECNGAKGTCHFYETMTSFWMYNLESSQPFERPQQQTIKAGERQSHVSRCQVCMKN 1777

Mouse  1707  1706
              Fly  1778  1777

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Col4a2NP_034062.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..253 100/239 (42%)
Collagen 67..121 CDD:189968 26/53 (49%)
Triple-helical region 184..1479 592/1495 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..476 91/223 (41%)
Collagen 312..387 CDD:189968 35/79 (44%)
Collagen 489..543 CDD:189968 29/65 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..900 170/455 (37%)
Collagen 783..842 CDD:189968 27/61 (44%)
Collagen 864..921 CDD:189968 27/71 (38%)
Collagen 900..959 CDD:189968 29/61 (48%)
Collagen 1007..1070 CDD:189968 28/62 (45%)
Collagen 1102..1161 CDD:189968 31/74 (42%)
Collagen 1147..1206 CDD:189968 26/63 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1195..1476 120/286 (42%)
Collagen 1324..1383 CDD:189968 32/61 (52%)
C4 1485..1589 CDD:279721 59/103 (57%)
C4 1594..1704 CDD:279721 66/109 (61%)
Col4a1NP_723044.1 Collagen 104..161 CDD:189968 31/62 (50%)
Collagen 322..380 CDD:189968 26/69 (38%)
Collagen 413..465 CDD:189968 23/62 (37%)
Collagen 499..561 CDD:189968 22/61 (36%)
Collagen 574..632 CDD:189968 26/57 (46%)
Collagen 657..714 CDD:189968 20/56 (36%)
Collagen 765..824 CDD:189968 30/82 (37%)
Collagen 854..911 CDD:189968 27/64 (42%)
Collagen 884..943 CDD:189968 27/58 (47%)
Collagen 923..982 CDD:189968 27/58 (47%)
Collagen 1028..1085 CDD:189968 30/56 (54%)
Collagen 1229..1287 CDD:189968 23/63 (37%)
Collagen 1318..1376 CDD:189968 33/93 (35%)
Collagen 1399..1458 CDD:189968 30/58 (52%)
Collagen 1477..1534 CDD:189968 27/62 (44%)
C4 1555..1662 CDD:128421 62/106 (58%)
C4 1663..1777 CDD:128421 69/113 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 146 1.000 Domainoid score I4520
eggNOG 1 0.900 - - E33208_3BAFZ
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H1390
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41315at33208
OrthoFinder 1 1.000 - - FOG0000443
OrthoInspector 1 1.000 - - mtm8822
orthoMCL 1 0.900 - - OOG6_100768
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2460
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.750

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