DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Col14a1 and Nrg

DIOPT Version :9

Sequence 1:	NP_001355351.1	Gene:	Col14a1 / 12818	MGIID:	1341272	Length:	1797	Species:	Mus musculus
Sequence 2:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster

Alignment Length:	667	Identity:	135/667 - (20%)
Similarity:	243/667 - (36%)	Gaps:	198/667 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse   295 VKNADLSELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTVCSRVEEQDKEIKASALATIGPPTE 359
            |.|.|.|.:.:::  |.:.:.:.|..|:.:.....|.....|:  .:.|...|        .|..
  Fly   667 VPNTDSSFVVQMS--PWANYTFRVIAFNKIGASPPSAHSDSCT--TQPDVPFK--------NPDN 719

Mouse   360 LITSEVTARSFMVNWTQSPGKVE------KYRVVY---YPTRGGKPEEVVVDGSVSSTVLKNLMS 415
            ::.......:.:::||..| ::|      .|.|.:   .|....:... :.|...::.|:.:..:
  Fly   720 VVGQGTEPNNLVISWTPMP-EIEHNAPNFHYYVSWKRDIPAAAWENNN-IFDWRQNNIVIADQPT 782

Mouse   416 STEYQIAVFAVS----AHTASE---GLRGAETTLALPMASDLELYDVTENSMRVRWDAVPGATGY 473
            ..:|.|.|.|::    ::.|:|   |..|.:..|..|          |..:||   ......:||
  Fly   783 FVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAP----------TNFTMR---QITSSTSGY 834

Mouse   474 LILYAPLT-EGLAGDEKEMKI------------------GETHTDIELSGLFPNTEYTVTVYAMF 519
            : .:.|:: |.:.|..|..||                  |:||..: ::...|:::....:.|..
  Fly   835 M-AWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNAL-VTQFKPDSKNYARILAYN 897

Mouse   520 GEEASDPATGQETTLP---LTPPRNLRISNVGSNSARLTWDP---ASGKISGYRIVYTSADGTEI 578
            |.....|:...:...|   .:|.:.|....:||::..|.|..   .:||::||:|.|.....:.:
  Fly   898 GRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYV 962

Mouse   579 NE-VEVDP------ITTFPLKGLTPLTEYSIAIFSIYEEGQS----------------LPLVGEF 620
            .| .|.||      :|...:.||.|.::|.|:|.:..:.|:.                .|....|
  Fly   963 GERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPSF 1027

Mouse   621 TTEEVPAQQYLEIDEVKTDSFRVTWHPLSAEEG--------QHKLMWIPVYGGKTQEVDLKEEQD 677
            :.|::|:...|.       .||:.|.|  :.||        .|::.      |:||.:...||::
  Fly  1028 SWEQLPSDNGLA-------KFRINWLP--STEGHPGTHFFTMHRIK------GETQWIRENEEKN 1077

Mouse   678 S--YVIEGLDPGTEYEVSLLAVLDDGSESEVVTAVGTTLDDFWTEAPTAIEPTSPVTSVLQTGIR 740
            |  ..:.||||.|.||..:::|  ||              .|.||:.|....|:.|..
  Fly  1078 SDYQEVGGLDPETAYEFRVVSV--DG--------------HFNTESATQEIDTNTVEG------- 1119

Mouse   741 NLVVDDETATSLRVSW-----------------------------DISDSNVEQFRVTYLKAQG- 775
            .::|.:||..:  ..|                             |:.|..:...|..|.:..|
  Fly  1120 PIMVANETVAN--AGWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEGGF 1182

Mouse   776 ----DPME------EVVGTVMVPGVQNSLLLKALLPDT----EYKVTVTPVYTVGEGVSVSAPGK 826
                .|::      :.|.:...|||::         ||    ||....|.|.|.....:.:|..|
  Fly  1183 HEYSQPLDNKSAGRQSVSSANKPGVES---------DTDSMAEYGDGDTAVATAAARAAAAARSK 1238

Mouse   827 --TLPSSGPQNLRVSEE 841
              :||:|..|..:..::
  Fly  1239 LTSLPTSTQQQQQQQQQ 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col14a1	NP_001355351.1	FN3	32..112	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..145
		vWA_collagen_alphaI-XII-like	158..321	CDD:238759	6/25 (24%)
		fn3	355..433	CDD:333790	15/90 (17%)
		FN3	448..517	CDD:214495	15/87 (17%)
		FN3	538..622	CDD:238020	26/109 (24%)
		FN3	631..708	CDD:238020	24/86 (28%)
		FN3	740..818	CDD:214495	21/121 (17%)
		fn3	833..909	CDD:333790	1/9 (11%)
		fn3	923..998	CDD:333790
		vWA_collagen_alphaI-XII-like	1032..1196	CDD:238759
		Nonhelical region (NC4)	1218..1459
		TSPN	1230..1425	CDD:214560
		Triple-helical region 1 (COL2)	1460..1611
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1463..1611
		Collagen	1484..1605	CDD:189968
		Cell attachment site. /evidence=ECO:0000255	1608..1610
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1645..1797
		Triple-helical region 2 (COL1)	1655..1780
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476
		I-set	339..427	CDD:254352
		Ig	354..427	CDD:299845
		I-set	432..517	CDD:254352
		Ig	446..517	CDD:299845
		I-set	522..611	CDD:254352
		ig	525..609	CDD:278476
		FN3	613..707	CDD:238020	8/41 (20%)
		FN3	716..807	CDD:238020	16/92 (17%)
		fn3	817..905	CDD:278470	18/102 (18%)
		FN3	917..1004	CDD:238020	24/86 (28%)
		FN3	1041..1111	CDD:238020	27/93 (29%)
		Bravo_FIGEY	1155..>1221	CDD:290593	14/74 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000