DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AgaP_AGAP002028 and gzl

DIOPT Version :9

Sequence 1:	XP_321026.4	Gene:	AgaP_AGAP002028 / 1281089	VectorBaseID:	AGAP002028	Length:	615	Species:	Anopheles gambiae
Sequence 2:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	209/587 - (35%)
Similarity:	306/587 - (52%)	Gaps:	124/587 - (21%)

- Green bases have known domain annotations that are detailed below.

Mosquito    37 RLVMLVAMVLMLAQ-PCVRADILVYQMLNDQIIEEFRDLPATFGGEIPDSGLKVLADRADPP-DG 99
            :::.|:.:.|:..: ..|...:|||:....|:||||.||||.||..:|.:||||....|..| .|
  Fly     7 QILTLLGLCLVCHEATLVGGHVLVYRKATSQLIEEFNDLPAQFGPNLPSNGLKVYVVPARRPYYG 71

Mosquito   100 CTEMRPAPNI----TSKFAVVIARYNCSFEVKVRNAQQAGYAMVIVHNVGSNDLEHMSANHPQDL 160
            |..:...|::    ::||..::||..|.||.|:|.||.|.|:.|||:|...:|||.|||.:...:
  Fly    72 CDSLDRPPHLKYPPSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDDLEQMSAENITGI 136

Mosquito   161 LIPSVFVGESAGRSIIEAYLYDHDYALVITDDIPFNISNNLIIPFAIVVGLCFIIMVLFMIIRCI 225
            .|||||||.:.|:::  |..:..:..|:|.|::||||:..||:||:|::|:||||||::||.:||
  Fly   137 RIPSVFVGHTTGKAL--ATYFTTEVVLIINDELPFNINTQLILPFSILIGMCFIIMVIYMIYKCI 199

Mosquito   226 RERRRRMRHRLPARVLRKIGIVKFAK---GMRFDTCAICLEDFVENERLRVLPCRHAYHAICIDP 287
            ||:||..|||||..:|:|:.::::.|   ..::|||.||||||:|:::||||||.|.||..||||
  Fly   200 REQRRLRRHRLPKSMLKKLPVLRYTKNNANNKYDTCVICLEDFIEDDKLRVLPCSHPYHTHCIDP 264

Mosquito   288 WLTKNRRVCPICKRRVIVRGEA---RQRRYSSDSMSSTNADESTPLLNSTEN-----------ST 338
            |||:||||||||||:|..:|||   |.|:.|.|:::.|: |::||||...::           |:
  Fly   265 WLTENRRVCPICKRKVFTKGEARASRSRQPSLDNVTDTD-DDTTPLLQQQQSNGRQVGQVSSASS 328

Mosquito   339 SGSAAGVVTAPPATSSSSPVTAAVAPSGNSGAGAQTAAAAAPQRDQQQLQQNAAPDSHVMEVPPS 403
            :|.|||        ||||...||||.:...|...:..|...|..:.|.                |
  Fly   329 AGGAAG--------SSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQS----------------S 369

Mosquito   404 DDDDEMLDDRNVPSARWLLRGRTSSQQQHQQQQQPQQQPLNESPYSP--IGDNVATPSR---WR- 462
            ||::.:|.....|:         :|...|:     :..|.:.:|..|  :.:.: |.||   |.
  Fly   370 DDENALLASTVRPA---------TSSGAHE-----RINPFDRAPNLPAHLAEQL-TESRRSVWSR 419

Mosquito   463 -FFQRFFTRSTAQSDTEGNNIQEPPAPAQAPSPQ-----PFSPTVPLGT--GNNILNAHLSGSFH 519
             .|..||.|..|..     ::..||...:..|..     |.:.|:.:.:  .|||||.:|||||.
  Fly   420 INFASFFRRQPAVI-----SVAAPPYLERVESGTSAMGLPVTGTIAVASPASNNILNPNLSGSFK 479

Mosquito   520 GSED---------------------TTDDELLDAMQRDRTKQRQFRSAPDMPSTSVGARLGVAAL 563
            ..:|                     |.||.             .|...|    |..|  :|||||
  Fly   480 DEDDMPPHRSIYEPIAISTPAADSATVDDS-------------AFLQTP----TQGG--IGVAAL 525

Mosquito   564 PN 565
            |:
  Fly   526 PH 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AgaP_AGAP002028	XP_321026.4	PA_C_RZF_like	51..197	CDD:239038	62/150 (41%)
AgaP_AGAP002028	XP_321026.4	zf-RING_2	256..300	CDD:290367	33/43 (77%)
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	63/158 (40%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	33/43 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	89	1.000	Domainoid score	I14499
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I5055
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		oto108113
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X670
TreeFam	1	0.960	-	-
	11	10.930