DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AgaP_AGAP002028 and C18B12.4

DIOPT Version :9

Sequence 1:	XP_321026.4	Gene:	AgaP_AGAP002028 / 1281089	VectorBaseID:	AGAP002028	Length:	615	Species:	Anopheles gambiae
Sequence 2:	NP_510498.1	Gene:	C18B12.4 / 181600	WormBaseID:	WBGene00007666	Length:	456	Species:	Caenorhabditis elegans

Alignment Length:	386	Identity:	105/386 - (27%)
Similarity:	166/386 - (43%)	Gaps:	68/386 - (17%)

- Green bases have known domain annotations that are detailed below.

Mosquito    78 FGGEIPDSGLKVLADR-------ADPPDGCTEMRPAPNITSK----FAVVIARYN----CSFEVK 127
            ||.::.|.   ::::.       .:|.|.|..:|.|.|.|::    ||.| :|.|    |.|..:
Worm    53 FGMDVSDF---IISEENLGCGVGVEPVDACGPVRIAQNHTTRCHNLFAFV-SRSNISHPCKFSHQ 113

Mosquito   128 VRNAQQAGY--AMVIVHNVGSNDLEHMSANHPQDLL-IPSVFVGESAGRSIIEAYLYDHDYALVI 189
            ....|.:.|  .:||.:|....:...|.....:|.: ||.:.:..:....|.:.:.....|.|.:
Worm   114 AFMVQNSTYPFRLVIFYNYPGQEPISMEGTELRDKVNIPVLMISHACKEEIAKKFSDTAGYRLRV 178

Mosquito   190 TDDIPFNISNNLIIPFAIVVGLCFIIMVLFMIIRCIR---ERRRRMRHRLPARVLRKIGIVKFAK 251
            ..|..:......:|||.:|:..||   .||:|..|:|   |||:..:.||..|.|:||.:.|:..
Worm   179 RIDPGYYELFRYLIPFLVVIVFCF---ALFLITLCVRGCVERRKLNKRRLSKRNLKKIPVKKYRL 240

Mosquito   252 GMRFDTCAICLEDFVENERLRVLPCRHAYHAICIDPWLTKNRRVCPICKRRVIVRGEARQRRYSS 316
            |...||||||||.|...|:||.|||||.:|..|||.|||:.|::||:|||::   |.......|:
Worm   241 GDDPDTCAICLESFASGEKLRHLPCRHVFHCNCIDVWLTQTRKICPLCKRKI---GTDSDSECST 302

Mosquito   317 DSMSSTN--ADESTPLLNSTE--------------------------------NSTSGSAAGVVT 347
            :.::||:  .:::|.|.|:.:                                |:|..|..|.|.
Worm   303 NDLASTSQGPNDATALYNNADNQSGFELPVPQGQMVDLWSSQEALVDQDIVLHNTTRRSITGFVR 367

Mosquito   348 APPATSSSSPVTAAVAPSGNSGAGAQTAAAAAPQRDQQQLQQNAAPD---SHVMEVPPSDD 405
            .......:||....|........|:..........|...|.:|...|   |..:.:|.|::
Worm   368 NAFRKLRNSPRHRDVDVHSGLEGGSYLVRQQTTSNDNDHLLENEVSDPTSSSELNIPSSEE 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AgaP_AGAP002028	XP_321026.4	PA_C_RZF_like	51..197	CDD:239038	30/136 (22%)
AgaP_AGAP002028	XP_321026.4	zf-RING_2	256..300	CDD:290367	27/43 (63%)
C18B12.4	NP_510498.1	PA	<74..176	CDD:333703	25/102 (25%)
		HRD1	<223..>335	CDD:227568	45/114 (39%)
		RING-H2_RNF103	246..291	CDD:319387	28/44 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	76	1.000	Domainoid score	I5871
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		oto35506
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.770