DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AgaP_AGAP002028 and RNF13

DIOPT Version :9

Sequence 1:	XP_321026.4	Gene:	AgaP_AGAP002028 / 1281089	VectorBaseID:	AGAP002028	Length:	615	Species:	Anopheles gambiae
Sequence 2:	NP_001365214.1	Gene:	RNF13 / 11342	HGNCID:	10057	Length:	381	Species:	Homo sapiens

Alignment Length:	424	Identity:	143/424 - (33%)
Similarity:	216/424 - (50%)	Gaps:	81/424 - (19%)

- Green bases have known domain annotations that are detailed below.

Mosquito    39 VMLVAMVLMLAQPCVRADILVYQMLNDQIIEEFRDLPATFGGEIPDSGLKVLADRADPPDGCTEM 103
            |.|.|.:.:|.   |.||||.|...|..  :.|.||||.||..:|..|||.....:.|.:.|..:
Human    21 VQLFAFLNLLP---VEADILAYNFENAS--QTFDDLPARFGYRLPAEGLKGFLINSKPENACEPI 80

Mosquito   104 RPAP---NITSKFAVVIARYNCSFEVKVRNAQQAGYAMVIVHNVGSNDLEHMSANHPQDLL---I 162
            .|.|   |.:..|.|:|.|.:|:|::||.|||:|||...|||||.|:||..|.:|..:.|.   |
Human    81 VPPPVKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDI 145

Mosquito   163 PSVFVGESAGRSIIEAYLYDHDYALVITDDIPFNISNNLIIPFAIVVGLCFIIMVLFMIIRCIRE 227
            ||||:|||:..|:.:.:.|:....|::..:....:...| |||.|:||:|.|::|:|||.:.:::
Human   146 PSVFIGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYL-IPFLIIVGICLILIVIFMITKFVQD 209

Mosquito   228 RRRRMRHRLPARVLRKIGIVKFAKGMRFDTCAICLEDFVENERLRVLPCRHAYHAICIDPWLTKN 292
            |.|..|:||....|:|:.:.||.||..:|.|||||:::.:.::||:|||.||||..|:||||||.
Human   210 RHRARRNRLRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKT 274

Mosquito   293 RRVCPICKRRVI-VRGEARQRRYSSDSMSS---TNADESTPLLNSTENSTSGSAAGVVTAPPATS 353
            ::.||:||::|: .:|::     .||:.||   ....|.||||.                 |..|
Human   275 KKTCPVCKQKVVPSQGDS-----DSDTDSSQEENEVTEHTPLLR-----------------PLAS 317

Mosquito   354 SSSPVTAAVAPSGNSGAGAQTAAAAAPQRDQQQLQQNAAPDSHVMEVPPSDDDDEMLDDRNVPSA 418
            .|                ||:..|.:..|..|.:.:::..:         :||:|..|
Human   318 VS----------------AQSFGALSESRSHQNMTESSDYE---------EDDNEDTD------- 350

Mosquito   419 RWLLRGRTSSQQQHQQQQQP---QQQPLNESPYS 449
                    ||..:::..:..   |.||..|..|:
Human   351 --------SSDAENEINEHDVVVQLQPNGERDYN 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AgaP_AGAP002028	XP_321026.4	PA_C_RZF_like	51..197	CDD:239038	59/151 (39%)
AgaP_AGAP002028	XP_321026.4	zf-RING_2	256..300	CDD:290367	24/43 (56%)
RNF13	NP_001365214.1	PA_C_RZF_like	23..180	CDD:239038	62/161 (39%)
		RING-H2_RNF167	238..283	CDD:319711	25/44 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..381		30/154 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	76	1.000	Domainoid score	I9239
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13493
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		otm55783
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780