Protein Alignment ADH5 and Fdh

DIOPT Version :10

• Sequence 1: NP_000662.3
• Gene: ADH5 / 128
• HGNCID: 253
• Length: 374
• Species: Homo sapiens
• Sequence 2: NP_524310.1
• Gene: Fdh / 41311
• FlyBaseID: FBgn0011768
• Length: 379
• Species: Drosophila melanogaster
• Alignment Length: 372
• Identity: 266/372 - (71%)
• Similarity: 314/372 - (84%)
• Gaps: 2/372 - (0%)

Human     4 EVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHE 68
            :||.|||||||||.|||.||:|||||||||||||||.||.||||||:|||||||||.|||:||||
  Fly     7 KVITCKAAVAWEAKKPLVIEDIEVAPPKAHEVRIKITATGVCHTDAFTLSGADPEGLFPVVLGHE 71

Human    69 GAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCK 133
            |||||||||||||..||||.||.||||||.|||||.:.|||||||||:|||.|:||:||||.:||
  Fly    72 GAGIVESVGEGVTNFKAGDHVIALYIPQCNECKFCKSGKTNLCQKIRLTQGAGVMPEGTSRLSCK 136

Human   134 GKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVF 198
            |:.:.|:||||||:|||||||||:.||:..|||:||||||||||||||||:||||:|.||.|||:
  Fly   137 GQQLFHFMGTSTFAEYTVVADISLTKINEKAPLEKVCLLGCGISTGYGAALNTAKVEAGSTCAVW 201

Human   199 GLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSK--PIQEVLIEMTDGG 261
            |||.|||||.:|||.|||.:|.|:|||.|||..||:||.|:.:||:|.:.  .||..||::||||
  Fly   202 GLGAVGLAVGLGCKKAGAGKIYGIDINPDKFELAKKFGFTDFVNPKDVADKGSIQNYLIDLTDGG 266

Human   262 VDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVE 326
            .||:|||||||..||:||||.|||||.|||:|||.:|:||:|||||||.||.|||:|||||:||.
  Fly   267 FDYTFECIGNVNTMRSALEATHKGWGTSVVIGVAGAGQEISTRPFQLVVGRVWKGSAFGGWRSVS 331

Human   327 SVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVK 373
            .|||||.:|:.|.:.||||:||.|...:||:||:|||.|:|||:::|
  Fly   332 DVPKLVEDYLKKDLLVDEFITHELPLSQINEAFDLMHKGESIRSIIK 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADH5	NP_000662.3	alcohol_DH_class_III	6..373	CDD:176260	264/368 (72%)
Fdh	NP_524310.1	alcohol_DH_class_III	9..378	CDD:176260	264/368 (72%)