DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADH5 and Drat

DIOPT Version :10

Sequence 1:NP_000662.3 Gene:ADH5 / 128 HGNCID:253 Length:374 Species:Homo sapiens
Sequence 2:NP_610293.3 Gene:Drat / 35687 FlyBaseID:FBgn0033188 Length:434 Species:Drosophila melanogaster


Alignment Length:390 Identity:82/390 - (21%)
Similarity:126/390 - (32%) Gaps:145/390 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    25 IEVAPPKAHEVRIKIIATAVCH---------TDAYTLSGADPEGC-------------------F 61
            ||..|  |...||:|:....|:         |...::|....:.|                   |
  Fly    81 IEDTP--ALGARIRIVCAGACYRRRDRANSITSMSSVSSELSDYCPSVNSMSSPAHQGIREGSFF 143

Human    62 PVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDG 126
            |   |.|.||::||:|..:|:                                  ...:||.   
  Fly   144 P---GFEVAGVIESLGSEITE----------------------------------ANNRGLR--- 168

Human   127 TSRFTCKGKTILHYMGTST---FSEYTVVADIS-VAKIDPLAPLDKVCLLGCGISTGYGA----- 182
                  .|:.::.|....|   ::|..||.|:. |..|....|::...:|..|....:.|     
  Fly   169 ------IGQRVIVYPFDETPAGYAELLVVPDLKHVVPIPDSLPMEVAAMLPTGALLAWNAVFKAQ 227

Human   183 AVNT------AKLEPGSVCAVFGLGGVGLAVIMGCKVA-------GASRI-IGVDINKDK-FARA 232
            ||.|      |..||.....:..:|..||| :...::|       ||..: |.|...:|: |..|
  Fly   228 AVVTQILSQRAATEPKRKPKILIVGTGGLA-LWAVRIASYHFATTGADNVDITVASLRDEGFRLA 291

Human   233 KEFGA------TECI-NPQDFSKPIQEVLIEMT----DGGVDYSFECIGNVKVMRAALEACHKGW 286
            .|...      .||: .||         |||.|    .|.||...:.....:.:..::....|| 
  Fly   292 TEIKNVSVVQWNECLYEPQ---------LIERTKDVCGGAVDVVIDFGTTSRSLHRSMHCLSKG- 346

Human   287 GVSVVVGVAASGEEIA----------TRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIK 341
                  ||....:|:|          :..:|........|||       |.:.:||....:|||:
  Fly   347 ------GVVLISDEVAEKLLPKFSRLSEQYQQEIIAISNGTA-------EQLAELVELVANKKIE 398

Human   342  341
              Fly   399  398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADH5NP_000662.3 alcohol_DH_class_III 6..373 CDD:176260 82/390 (21%)
DratNP_610293.3 MDR 144..428 CDD:450120 70/325 (22%)

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