Protein Alignment CG43058 and RNF4

DIOPT Version :10

• Sequence 1: NP_001246302.1
• Gene: CG43058 / 12798445
• FlyBaseID: FBgn0262360
• Length: 100
• Species: Drosophila melanogaster
• Sequence 2: NP_002929.1
• Gene: RNF4 / 6047
• HGNCID: 10067
• Length: 190
• Species: Homo sapiens
• Alignment Length: 147
• Identity: 36/147 - (24%)
• Similarity: 52/147 - (35%)
• Gaps: 64/147 - (43%)

  Fly    18 NEIIDLCSPQKQPV-----------------------KRLRSDLGDS------DEP-------YM 46
            :||:||.....:||                       :||..|..||      ||.       |:
Human    44 DEIVDLTCESLEPVVVDLTHNDSVVIVDERRRPRRNARRLPQDHADSCVVSSDDEELSRDRDVYV 108

  Fly    47 -----------------------CPICMENVRR-----RQPAATPCGHVFCYDCIQKAIGDYKKC 83
                                   |||||:....     |...:|.||||||..|::.::.:...|
Human   109 TTHTPRNARDEGATGLRPSGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNANTC 173

  Fly    84 PMCNKKIMYKQLTRIFL 100
            |.|.|||.:|:...|::
Human   174 PTCRKKINHKRYHPIYI 190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43058	NP_001246302.1	RING_Ubox	47..99	CDD:473075	21/56 (38%)
RNF4	NP_002929.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Required for ubiquitination activity. /evidence=ECO:0000250|UniProtKB:Q9QZS2	1..16
		Mediates interaction with TRPS1. /evidence=ECO:0000250|UniProtKB:Q9QZS2	4..61		6/16 (38%)
		SUMO interaction motif 1. /evidence=ECO:0000269|PubMed:18408734	36..39
		SUMO interaction motif 2. /evidence=ECO:0000269|PubMed:18408734	46..49		1/2 (50%)
		SUMO interaction motif 3. /evidence=ECO:0000269|PubMed:18408734	57..59		1/1 (100%)
		SUMO interaction motif 4. /evidence=ECO:0000269|PubMed:18408734	67..70		0/2 (0%)
		RING-HC_RNF4	127..183	CDD:438195	20/55 (36%)