Protein Alignment CG43335 and KLK1

DIOPT Version :10

• Sequence 1: NP_001247121.1
• Gene: CG43335 / 12798413
• FlyBaseID: FBgn0263040
• Length: 281
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 81/266 - (30%)
• Similarity: 123/266 - (46%)
• Gaps: 53/266 - (19%)

  Fly    39 RTRIIGGSDAEITSHPWMAYLYNEFHYFCAGTLITNQFVLTAAHCIEASKNLTVRLGGSGLTRSD 103
            ::||:||.:.|..|.||.|.||:...:.|.|.|:..|:||||||||  |.|..:.||...|...:
Human    22 QSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCI--SDNYQLWLGRHNLFDDE 84

  Fly   104 GSMCQITAEDYSVSMAIKHKYFTPSIMLN-----------DIAMIRLARTVKFYDHIRPICIILD 157
            .     ||:...||.:..|..|..|::.|           |:.::||.         .|...|.|
Human    85 N-----TAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLT---------EPADTITD 135

  Fly   158 PAVRLL------LEDGMTLMATGWGLADKR--MHPHLLQEAPITVMNRNVCSKLYDVAITQGQIC 214
             ||:::      .|.|.|.:|:|||..:..  ..|..||...:.::..:.|.|.:...:|...:|
Human   136 -AVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLC 199

  Fly   215 AGDKE--TNTCLGDSGGPL--GGVVNYYGDLRFVQYGITSFGDIEC---RSPSIYTDLSTYSGWI 272
            .|..|  .:||:|||||||  .||:.          |:||:|.:.|   ..||:...:.:|..||
Human   200 VGHLEGGKDTCVGDSGGPLMCDGVLQ----------GVTSWGYVPCGTPNKPSVAVRVLSYVKWI 254

  Fly   273 NMVVSQ 278
            ...:::
Human   255 EDTIAE 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43335	NP_001247121.1	Tryp_SPc	42..275	CDD:238113	80/258 (31%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	80/258 (31%)