Protein Alignment CG43110 and TMPRSS9

DIOPT Version :10

• Sequence 1: NP_001246396.1
• Gene: CG43110 / 12798330
• FlyBaseID: FBgn0262570
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_001382442.1
• Gene: TMPRSS9 / 360200
• HGNCID: 30079
• Length: 1093
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 132/592 - (22%)
• Similarity: 213/592 - (35%)
• Gaps: 158/592 - (26%)

  Fly    26 QPCGKTPV----PKIISGSNASQQSAQYMAGIFNTTHLLCGGTIIHEDFVLTVAHC-KSTQTLFV 85
            |.||..|.    .:::.|..|:.....:...:...:...||.|::.:.::|:.||| ..|:...|
Human   524 QECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQV 588

  Fly    86 R--LGAYNI----NHPTDQIRVIETIAHPQYSNSTYANDIALVKLERSVIFNLNIQPICIHLDAT 144
            |  ||..::    ..|. :|.:...:.||.|:......|:|:::|...:.||..|||:|:.|...
Human   589 RAHLGTASLLGLGGSPV-KIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQ 652

  Fly   145 LGKQIRYYNAFGWGRTR--NAEQSDILQRIFVNRTNPMICHLYLGMSPDPKQICATTDQG--DTC 205
            .....|.....|||.|:  ||.:.::||:..|...:...|.:....|...:.|||...:|  |:|
Human   653 KFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDSC 717

  Fly   206 AGDSGGPLISK----ITYQGKNFDTQFGITSYGTRECNGV---GLYTDVSQYSGWIANIVRSK-- 261
            .|||||||..:    :.|..       ||.|:|. .|..|   |:||.:::..|||..|:.|:
Human   718 QGDSGGPLACEEAPGVFYLA-------GIVSWGI-GCAQVKKPGVYTRITRLKGWILEIMSSQPL 774

  Fly   262 ----------------------------------------------QDRSVVSRRSNGMFLY--- 277
                                                          ...|.||..:.|...:
Human   775 PMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTPGAASRVTGQPANSTLSAVSTTARGQTPFPDA 839

  Fly   278 ---------SDCTGDSIGSILMATIVGLQYSAKG-------------------VLITDRHVLTTA 314
                     .||   .:....:..|||...:.:|                   ||:.:|.:|:.|
Human   840 PEATTHTQLPDC---GLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAA 901

  Fly   315 -------DFSQDNPFSLAIVVMGMEFQ---ASAIFK-PF-----ADINISLISLTRRLENRGALR 363
                   |..|...|.....:.|.|.|   .:.|:| ||     .|.:::|:.|...:.....:|
Human   902 HCFDVYGDPKQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVR 966

  Fly   364 PICILETANIA-----------GSLRITGTGQYGLSNYVINVQSLNWQLCELELRRNIEQNQFCV 417
            |||:.|.|...           ||:|..|:....|....:.:  |:.|.|.......|.....|.
Human   967 PICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRL--LSEQTCRRFYPVQISSRMLCA 1029

  Fly   418 KNTFQPNALKQ-FGTAGDILVKKILNVSGMVHFVLLGLVDVSHN-------DVYVITSAMANAEW 474
              .|....:.. .|.||..|..:  ..||  .:||.|:....:.       .||...:|:..  |
Human  1030 --GFPQGGVDSCSGDAGGPLACR--EPSG--RWVLTGVTSWGYGCGRPHFPGVYTRVAAVRG--W 1086

  Fly   475 ISKIVNQ 481
            |.:.:.:
Human  1087 IGQHIQE 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43110	NP_001246396.1	Tryp_SPc	36..257	CDD:238113	67/238 (28%)
TMPRSS9	NP_001382442.1	SEA	66..>127	CDD:460188
		LDLa	188..223	CDD:238060
		Tryp_SPc	236..465	CDD:214473
		Tryp_SPc	538..768	CDD:238113	67/238 (28%)
		Pneumo_att_G	<717..>867	CDD:114270	32/160 (20%)
		Tryp_SPc	861..1087	CDD:238113	51/235 (22%)