Protein Alignment CG43110 and HPN

DIOPT Version :10

• Sequence 1: NP_001246396.1
• Gene: CG43110 / 12798330
• FlyBaseID: FBgn0262570
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 84/285 - (29%)
• Similarity: 124/285 - (43%)
• Gaps: 46/285 - (16%)

  Fly    16 CQLAYSMFLK---QPCG--KTPVPKIISGSNAS------QQSAQYMAGIFNTTHLLCGGTIIHED 69
            |......||.   |.||  |.||.:|:.|.:.|      |.|.:|     :..| ||||:::..|
Human   138 CDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRY-----DGAH-LCGGSLLSGD 196

  Fly    70 FVLTVAHC-------KSTQTLFVRLGAYNINHPTDQIRVIETIAHPQY------SNSTYANDIAL 121
            :|||.|||       .|...:|....|....|.. |:.|...:.|..|      ::...:|||||
Human   197 WVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGL-QLGVQAVVYHGGYLPFRDPNSEENSNDIAL 260

  Fly   122 VKLERSVIFNLNIQPICIHLDATLGKQI---RYYNAFGWGRTR-NAEQSDILQRIFVNRTNPMIC 182
            |.|...:.....|||:|:   ...|:.:   :.....|||.|: ..:|:.:||...|...:..:|
Human   261 VHLSSPLPLTEYIQPVCL---PAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVC 322

  Fly   183 H--LYLGMSPDPKQICATTDQG--DTCAGDSGGPLISKITYQGKNFDTQFGITSYGTREC---NG 240
            :  .:.|....||..||...:|  |.|.||||||.:.:.:..........||.|:|| .|   ..
Human   323 NGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGT-GCALAQK 386

  Fly   241 VGLYTDVSQYSGWIANIVRSKQDRS 265
            .|:||.||.:..||...:::..:.|
Human   387 PGVYTKVSDFREWIFQAIKTHSEAS 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43110	NP_001246396.1	Tryp_SPc	36..257	CDD:238113	74/250 (30%)
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	7/20 (35%)
		Tryp_SPc	163..400	CDD:238113	72/247 (29%)