Protein Alignment CG43110 and F10

DIOPT Version :10

• Sequence 1: NP_001246396.1
• Gene: CG43110 / 12798330
• FlyBaseID: FBgn0262570
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_000495.1
• Gene: F10 / 2159
• HGNCID: 3528
• Length: 488
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 79/265 - (29%)
• Similarity: 123/265 - (46%)
• Gaps: 47/265 - (17%)

  Fly    29 GKTPVPKIISGSNASQQSAQYMAGIFNTTHL-LCGGTIIHEDFVLTVAHCKSTQTLF-VRLGAYN 91
            |...:.:|:.|.........:.|.:.|..:. .|||||:.|.::||.|||......| ||:|..|
Human   228 GDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRN 292

  Fly    92 INHPTDQ------IRVIE-TIAHPQYSNSTYANDIALVKLERSVIFNLNIQPICI----HLDATL 145
                |:|      :..:| .|.|.:::..||..|||:::|:..:.|.:|:.|.|:    ..::||
Human   293 ----TEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTL 353

  Fly   146 GKQIRYYNAFGWGRT----RNAEQSDILQRIFVNRTNPMICHLYLGMSPDPKQICA--TTDQGDT 204
            ..| :.....|:|||    |.:.:..:|:..:|:|.:   |.|...........||  .|.|.|.
Human   354 MTQ-KTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNS---CKLSSSFIITQNMFCAGYDTKQEDA 414

  Fly   205 CAGDSGGPLISKITYQGKNFDTQF--GITSYGTREC---NGVGLYTDVSQYSGWIANIVRSKQDR 264
            |.||||||.:::..      ||.|  ||.|:| ..|   ...|:||.|:.:..||        ||
Human   415 CQGDSGGPHVTRFK------DTYFVTGIVSWG-EGCARKGKYGIYTKVTAFLKWI--------DR 464

  Fly   265 SVVSR 269
            |:.:|
Human   465 SMKTR 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43110	NP_001246396.1	Tryp_SPc	36..257	CDD:238113	74/244 (30%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:464251
		O-glycosylated at one site	183..203
		Tryp_SPc	235..464	CDD:238113	74/251 (29%)
		O-glycosylated at one site	476..485