DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43235 and CPA1

DIOPT Version :9

Sequence 1:	NP_001245931.1	Gene:	CG43235 / 12798301	FlyBaseID:	FBgn0262880	Length:	103	Species:	Drosophila melanogaster
Sequence 2:	NP_001859.1	Gene:	CPA1 / 1357	HGNCID:	2296	Length:	419	Species:	Homo sapiens

Alignment Length:	114	Identity:	25/114 - (21%)
Similarity:	48/114 - (42%)	Gaps:	29/114 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPQIAMLLLITAWKSSLSDPIGPRSYENYSVYKVFIKTRSDQQVIDGLLKDTDNYNL--W---- 59
            ||..:.:.:|:.|       ..|...:..:.|.::.:...:..|.:.. |:|.::..|  |
Human     1 MRGLLVLSVLLGA-------VFGKEDFVGHQVLRISVADEAQVQKVKE-LEDLEHLQLDFWRGPA 57

  Fly    60 HRGLNVVHIMVSPVEK----DSFLAV---MQKENIVVEVLIKNVQTLID 101
            |.|        ||::.    .|..||   ::...|..|.:|::||:|:|
Human    58 HPG--------SPIDVRVPFPSIQAVKIFLESHGISYETMIEDVQSLLD 98

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43235	NP_001245931.1	Propep_M14	34..102	CDD:280416	19/81 (23%)
CPA1	NP_001859.1	Propep_M14	32..100	CDD:396700	19/76 (25%)
		M14_CPA	117..417	CDD:349442
		Substrate binding. /evidence=ECO:0000269\|PubMed:18566513, ECO:0007744\|PDB:2V77	179..182
		Substrate binding. /evidence=ECO:0000269\|PubMed:18566513, ECO:0007744\|PDB:2V77	254..255
		Substrate binding. /evidence=ECO:0000269\|PubMed:18566513, ECO:0007744\|PDB:2V77	307..308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900