DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43332 and Muc20

DIOPT Version :9

Sequence 1:	NP_001246028.1	Gene:	CG43332 / 12798213	FlyBaseID:	FBgn0263037	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001139346.1	Gene:	Muc20 / 224116	MGIID:	2385039	Length:	688	Species:	Mus musculus

Alignment Length:	706	Identity:	194/706 - (27%)
Similarity:	282/706 - (39%)	Gaps:	150/706 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTALEISIST-TQT---------TTTELIPCIIFPSLPLCAQ--STESAFTTSKDITTTAASPT 53
            ::|...:.:|| ||.         .||.||..:     ||..|  |||||.....  .|:.:|..
Mouse    35 LVTTNNMEVSTFTQRDRPSSERAFQTTNLIQYV-----PLDTQTLSTESASNALS--ATSISSEV 92

  Fly    54 TAKDLKTT-----TENFPTTTNPPSTTKGITTSESIPCKDF-------------PYLPICLVSTT 100
            .::|.:||     |....|||...|:.:..|||.::...:.             ...|:.|..:|
Mouse    93 NSRDTQTTSFVTKTRKTHTTTPAASSLEAQTTSPNLSTLNIQITSPIASSLDAQTIFPVSLSLST 157

  Fly   101 TTT----SITDSTTT----RDITTTAA------SPTTAEDLKTTTPAPTTTDNKPTTTNAPTTTE 151
            .||    |..|:.||    ..:||:.|      |||.:.  .||:|||:..|.: ||:.||::
Mouse   158 QTTSPAPSFLDTQTTSPEPSSLTTSPAPSSLITSPTPSS--LTTSPAPSFLDTQ-TTSPAPSS-- 217

  Fly   152 GITTTDSIQCKDFPYL-PICLVSTTTTTSITDSTTTRDITTTAASP-TTAEDLKTTTPAPTTTDN 214
             :||:.:....|...: ||.|  |..|.:|:..|.||.::....|. |....:.|.|.||:   |
Mouse   218 -LTTSPAPSSLDTQTISPIEL--TLKTQTISTVTETRTVSIRIPSDLTVMHTIPTETLAPS---N 276

  Fly   215 KPTTTNAPTTTEGITTTDSIQCKDFPYLPICLVSTTTATSISDSTTAK---DITTTAASPTTAED 276
            .|.|  ..:|.:..|..|||:.          |..|..|..|.....|   |:.|.|.:.|..|.
Mouse   277 SPRT--GMSTVQTGTVWDSIEA----------VFDTLCTDDSSEEARKITVDLLTLAHTSTEVEY 329

  Fly   277 LKTTTPVPTTTDN----ISTT----TNAPTTTEGITTTDSIQCKDFPYLPICLVSTTTTTSISDS 333
            |.:.:  .:::|:    :|::    .::.|..:|:...:....|    |..|:....||.:||.:
Mouse   330 LSSES--SSSSDSSAGVLSSSRVLGPDSATPAKGLVAFNITHIK----LSNCITEIETTITISGA 388

  Fly   334 T-TTKDITTTAASPTTAEDLKTTTPAPTTTDNI-PTTTN-----------APTTTKEITTTTSAS 385
            . .:...|...|:..|:|.|  |.|.||....| |.||:           |..||.|.|.:|||.
Mouse   389 PGASLSPTEATAALFTSEIL--TLPPPTEAKPIFPETTSLSGILSTAGTPALATTLEGTVSTSAI 451

  Fly   386 STDETT---TTTAPTTTKDITTTTLAPTSTAEITTTT----LGPTTTVEITTTNTSPTATEELTT 443
            :..||.   |.|:..|:..:....|..|||..|.|.:    || |.||.:...:|...|...::.
Mouse   452 TESETAVAQTLTSVGTSVTVRRNPLENTSTLSIETQSHTEVLG-TITVPMVAGSTMGEAASFVSF 515

  Fly   444 TTEDKTTTTAAPTTAVSSTTTEEPSTSTTTEEITTTTSSTAEEATTTTASPTTTEELTTTISPTT 508
            |..|.::.:...||. ||.|:|..:|..||.....|.|.......:||||  |::....|::.||
Mouse   516 TALDSSSLSVVVTTE-SSATSETLTTGNTTNSSFLTESHPPFSIYSTTAS--TSKNPNITLTKTT 577

  Fly   509 TSLAPTTTEDNSNTASTTTEEITTTTLSTSTEE----LTTTTTAPSNPQAQHHYHHH-------H 562
            .|..|.|    ..|.|.:|..|..||.....|:    |...|.|......:|:....       |
Mouse   578 ASPKPPT----HPTTSASTAWIRKTTKHDPGEDGGFLLVRLTVASPKDLTEHNAREKLMNQIVTH 638

  Fly   563 EVIGPPAFPLPPPRFPLPPPPFPFIGSLPEADSAVIAILPIPPPPPIPAFPRPPPR 618
            |..||...|....|...|       ..|..:.||         .|..||..|||.|
Mouse   639 EPSGPGHLPSRWGRSGRP-------SWLLHSSSA---------SPAEPAGGRPPSR 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43332	NP_001246028.1	None
Muc20	NP_001139346.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..125		11/39 (28%)
		PRK11907	93..>201	CDD:237019	28/109 (26%)
		PRK11907	151..>266	CDD:237019	38/122 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..232		25/78 (32%)
		Approximate repeats	180..227		18/52 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..348		3/20 (15%)
		Involved in oligomerization. /evidence=ECO:0000250	399..603		68/213 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..592		13/37 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000