DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plk3 and SAK

DIOPT Version :9

Sequence 1:	NP_038835.2	Gene:	Plk3 / 12795	MGIID:	109604	Length:	648	Species:	Mus musculus
Sequence 2:	NP_649324.1	Gene:	SAK / 40384	FlyBaseID:	FBgn0026371	Length:	769	Species:	Drosophila melanogaster

Alignment Length:	420	Identity:	135/420 - (32%)
Similarity:	202/420 - (48%)	Gaps:	60/420 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    51 GRLITDPLSGRTYTKGRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVAKPHQREKILNEIELH 115
            |..|.|      |....||||||||..|:|....:....|:|:|.:..:.......::..|:|:|
  Fly     8 GETIED------YEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIH 66

Mouse   116 RDLQHRHIVRFSHHFEDADNIYIFLELCS----RKSLAHIWKARHTLLEPEVRYYLRQILSGLKY 176
            ..|:|..:::....|:||:.:|:.|||..    .:.:.||  || ...|.|....|:|:::||.|
  Fly    67 SRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHI--AR-PFTETEAASILKQVVAGLLY 128

Mouse   177 LHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE 241
            ||...|:|||:.|.|..::..|.:|:.|||||.:|:.|::|..|:||||||::|||:.|..||..
  Fly   129 LHSHNIMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLP 193

Mouse   242 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSI 306
            |||||:||::||||.|.|||||..::.|...:....|.:||.||..|:.|:..:|:..|.:|.::
  Fly   194 ADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITL 258

Mouse   307 EQILRHDFFTKGYTPDRLPVSSCVTVPDLTPPNPARSLFAKVTKS------LFGRKKNKNKNHSE 365
            |.:|.|.|..|           |.......|  .|.::|::..:|      .|....::|.....
  Fly   259 EAVLCHPFMLK-----------CSNGGHSAP--GALNVFSQSMESGDSGIITFASSDSRNSQQIR 310

Mouse   366 DQDNVSCLVSGLMRTSIGHPDVRPEAPVVS-----------GQAPASLVETAAEDSSPRGTLASS 419
            ..:|     ||..:..   |.:|.|...|.           |||...|    ||.:.| |...||
  Fly   311 SVEN-----SGPQQVL---PQIREEFKQVHHKLPYEQTGLFGQASTGL----AEPNWP-GAAKSS 362

Mouse   420 GDGFEEGLTVATVVESALCALRNCVAFMPP 449
            ....|.|    .|..|...:|:.....:||
  Fly   363 AFCMEAG----NVPNSKQASLKEDRISVPP 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plk3	NP_038835.2	STKc_PLK3	61..315	CDD:271091	99/257 (39%)
		S_TKc	63..315	CDD:214567	99/255 (39%)
		POLO_box_1	462..550	CDD:240561
		POLO_box_2	563..630	CDD:240560
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	100/263 (38%)
		S_TKc	14..267	CDD:214567	99/255 (39%)
		POLO_box_Plk4_1	382..497	CDD:240557	2/7 (29%)
		POLO_box_Plk4_2	498..596	CDD:240558
		POLO_box_Plk4_3	657..738	CDD:240559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507604at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820