DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COL1A2 and Muc11A

DIOPT Version :9

Sequence 1:	NP_000080.2	Gene:	COL1A2 / 1278	HGNCID:	2198	Length:	1366	Species:	Homo sapiens
Sequence 2:	NP_001285150.1	Gene:	Muc11A / 32174	FlyBaseID:	FBgn0052656	Length:	1552	Species:	Drosophila melanogaster

Alignment Length:	1381	Identity:	382/1381 - (27%)
Similarity:	476/1381 - (34%)	Gaps:	289/1381 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    29 TVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPPGPP-----GPPGPPGLGGNFA--AQYDGKGV 86
            |...|...|    |....||.|.    ||.:..||.|     ..||.|..|.:.|  |..||...
  Fly   298 TAAPGAPAD----GSSAAPGSPA----DGSSAAPGSPADVTTAAPGAPADGSSAAPGAPADGSSA 354

Human    87 GLG-PGPMGLMGPRGP-PGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGK 149
            ..| |..:....|..| .|::.|||... :|.:..||.|.....|....||        ||....
  Fly   355 APGSPADVTTAAPGAPADGSSAAPGSPA-EGSSAAPGAPADVTTAAPGAPA--------DGSSAA 410

Human   150 PGRPGERGVVGPQGARGFP-----GTPGLPGFKGIRGHNGLDGLKGQPGAP--GVKGEPGAPGEN 207
            ||.|.:    |...|.|.|     ..||.|.          ||....||:|  |....||||.:
  Fly   411 PGAPAD----GSSAAPGSPADVTTAAPGAPA----------DGSSAAPGSPAEGSSAAPGAPAD- 460

Human   208 GTPGQTGARGLP--GERGRVGAP--GPAGARGSDGSVGPVGPAGPI-GSAGPPGFP-----GAPG 262
               ..|.|.|.|  |.....|||  |.:.|.||...|....|..|. ||:..||.|     .|||
  Fly   461 ---VTTAAPGAPADGSSAAPGAPADGSSAAPGSPADVTTAAPGAPADGSSAAPGAPADGSSAAPG 522

Human   263 PKGEI-----GAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPG 322
            ...::     ||..:...|.|..|..|..        ..||:| |:..|.|.||.. .|.:.|||
  Fly   523 SPADVTTAAPGAPADGSSAAPGSPAEESS--------AAPGSP-ADVTTAAPGAPA-DGSSAAPG 577

Human   323 LPGPRGIPGPVGAAGATGARGLVGEPG-PA-GSKGESGNKGEPGSAGPQGP-------PGPSGEE 378
            .|.......|...|..|.|     .|| || ||....|:..|..||.|..|       ||...:.
  Fly   578 APADGSSAAPGSPADVTTA-----APGAPADGSSAAPGSPAEGSSAAPGAPADVTTAAPGAPADG 637

Human   379 GKRGPNGEA-GSAGPPGPP-----GLRGSP--GSRGLPG--ADGRAGVMGPPGSRGASGPAGVRG 433
            ....|...| ||:..||.|     ...|:|  ||...||  |||.:...|.|.....:.|..  .
  Fly   638 SSAAPGAPADGSSAAPGSPADVTTAAPGAPADGSSAAPGAPADGSSAAPGSPADVTTAAPGA--P 700

Human   434 PNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPV-GLPGIDGRPGPIGPAGARGEPGNIGFPGP 497
            .:|.:..||.|. .|....||||.::..|....|. |.....|.|.. |.:.|.|.|.::....|
  Fly   701 ADGSSAAPGSPA-EGSSAAPGSPADVTTAAPGAPADGSSAAPGAPAD-GSSAAPGSPADVTTAAP 763

Human   498 KGP----TGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLP 558
            ..|    :..||...|...|    |.|||. ||::.|.|.|       .:|....||.|......
  Fly   764 GAPADGSSAAPGSPADVTTA----APGAPA-DGSSAAPGSP-------AEGSSAAPGSPADVTTA 816

Human   559 GPSGPA-GEVGKPGERGLHGEFGLPG------PAGPRGERGPPGESGAAGPTGPI--GSRGPSGP 614
            .|..|| |....||... .|....||      .|.|    |.|.:..:|.|..|.  .|..|..|
  Fly   817 APGAPADGSSAAPGAPA-DGSSAAPGSPADVTTAAP----GAPADGSSAAPGAPADGSSAAPGSP 876

Human   615 -------PG--PDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEI--GN 668
                   ||  .||:...||....|.||.|..|:  .|...|.|.| .:|....||...::  ..
  Fly   877 ADVTTAAPGAPADGSSAAPGSPADVTTAAPGAPA--DGSSAAPGSP-AEGSSAAPGAPADVTTAA 938

Human   669 PG--RDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPA-GPRGSPGERGEVGPAGPNGFA-GPA 729
            ||  .||:..|||| .|.|.:.|.|...:...|.|..|| |...:||...:|..|.|...| |.:
  Fly   939 PGAPADGSSAAPGA-PADGSSAAPGSPADVTTAAPGAPADGSSAAPGAPADVTTAAPGAPADGSS 1002

Human   730 GAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGM-TGFPGAA- 792
            .|.|.| |:|...|.|...:.....|..|  |.|.:...|.|....|...|.|..: |..|||.
  Fly  1003 AAPGSP-AEGSSAAPGAPADVTTAAPGAP--ADGSSAAPGAPADGSSAAPGSPADVTTAAPGAPA 1064

Human   793 -GRTGPPG-------------PSGISGPPGPPG----PAGKEGLRGPRGDQGPVGRTGEVGAVGP 839
             |.:..||             ..|.|..||.|.    |||    ..|.|...|.|        |.
  Fly  1065 DGSSAAPGSPADVTTAAPGAPADGSSAAPGSPAEGSPPAG----GSPAGSNVPAG--------GD 1117

Human   840 PGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLP--GSRGERGLPGVAGAVGEPGPLGI--A 900
            |  |....|:|.|    |..:..|.|  |||....:|  |:..:..:|    |.|.|....:  .
  Fly  1118 P--ADSNVPAGGA----PADSNVPAG--GAPADSNVPAGGAPADSNVP----AGGAPADANVPAG 1170

Human   901 GPPGARGPPGAVGSPGVNGAP-GEAGRDGN-PGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAP 963
            |.|.....||. |:|.....| |.|..|.| |....|.|.:...|     |.|.: ..|.|.|||
  Fly  1171 GAPADSNVPGG-GAPADANVPAGGAPADSNVPAGGAPAGSNVPAG-----GAPAD-SNVPAGGAP 1228

Human   964 GPHG-PVG--PAGKHGNRGETGPS---GPVGPAGAVGPRGPSGPQGIRGDKGEPGEK----GPRG 1018
            .... |.|  |||.:...|.:..|   ||..|||:|.|..|..|.|.......|...    .|..
  Fly  1229 ADSNVPAGGAPAGSNVPAGSSPGSSVLGPNPPAGSVVPSIPVLPGGAGSWPWHPRPNIPIVPPTW 1293

Human  1019 LPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPA-----GPSGPAGKDGRTGHPGTVGPAG 1078
            .|.|.|.|| .|.||....:|....|....|..|...:     .|:.|.        |.|..|..
  Fly  1294 RPLLPGQNG-SGAPGSGLINGIVNPPQRPHPFWPNWQSWVNSWRPTKPV--------PSTEAPVQ 1349

Human  1079 IRGPQGHQGPAGPPGPPGP----------PGPPGVSGGGYDFGYDGDFYRA-------------D 1120
            .:.||..|.|. .||...|          |.||.......:.....|..:|             |
  Fly  1350 PQNPQQPQNPQ-QPGNSNPETAESVEQAAPVPPANVPASNENASVEDSNKASSEKSKDKPKSGED 1413

Human  1121 QPRSAPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQG 1185
            |.:.....:|...|.:...|..|::     ..:..:.|.::..:|......:..|.    ..|.|
  Fly  1414 QSKEQEQKKPSSEEKEKDSKEKNDK-----DSKEKKDNDSKDKKDKSKEEKDNESQ----KDNDG 1469

Human  1186 -----------CTMDAIKVYCDFSTGETCIR--AQPENIPAKNWYRS--SKDKKHVWLGETINAG 1235
                       ...|.||   ....|:.|..  ..|:....:.:||.  .|..||.:.....:..
  Fly  1470 DDEPSSKEKKQYVKDLIK---KLKKGDECDEDDVYPDVRDCRKYYRCEVKKSGKHKFAHLRCDKK 1531

Human  1236 SQFEYNVEGVTSKEMA 1251
            .:|::..:....|:.|
  Fly  1532 ERFDWLTQSCVPKDEA 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COL1A2	NP_000080.2	Collagen	115..174	CDD:189968	18/63 (29%)
		Collagen	148..207	CDD:189968	20/65 (31%)
		Collagen	187..246	CDD:189968	22/64 (34%)
		Collagen	268..327	CDD:189968	19/58 (33%)
		Collagen	436..497	CDD:189968	18/61 (30%)
		Collagen	469..528	CDD:189968	19/62 (31%)
		Collagen	580..649	CDD:189968	25/85 (29%)
		Collagen	919..973	CDD:189968	19/58 (33%)
		Collagen	955..1013	CDD:189968	23/63 (37%)
		COLFI	1134..1365	CDD:279718	22/133 (17%)
Muc11A	NP_001285150.1	PRK07764	<366..816	CDD:236090	151/507 (30%)
		PRK07764	<696..1109	CDD:236090	131/444 (30%)
		CBM_14	1495..1547	CDD:279884	9/51 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000