DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ccr4 and TkR86C

DIOPT Version :9

Sequence 1:	XP_006511995.1	Gene:	Ccr4 / 12773	MGIID:	107824	Length:	467	Species:	Mus musculus
Sequence 2:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	106/435 - (24%)
Similarity:	186/435 - (42%)	Gaps:	95/435 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse    87 IAAQLFSLASPAGTRSATIPKMNATEVTDTTQD--------ETVYNSYYFYES--MPKPCTKEGI 141
            :|.:.|.|.|...|  ..:..:|.|||......        |::..:..|...  .|.|.....:
  Fly    16 LAVRRFELNSIVNT--TLLGSLNRTEVVSLLSSIIDNRDNLESINEAKDFLTECLFPSPTRPYEL 78

Mouse   142 KAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLL---------FVL 197
            ....:.....::.|:..:.:.||.:|:.::..::.::::|:.:||||:|:|||         |:.
  Fly    79 PWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIF 143

Mouse   198 SLPFWGYYAADQWVFGLGLCKIVSWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGV 262
            .|       ...|.||...|.|.:::..|...:.:|.::.:|.|||:||||   .||.||....|
  Fly   144 ML-------NSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVH---PLKRRTSRRKV 198

Mouse   263 -ITSLITWSVAVFASLPGLLFSTCYTEH-----NHTYC------------KTQYSVNSTTWKVLS 309
             |..::.|:::...|.|.||:|:..|:|     :.|.|            ...|:.|
  Fly   199 RIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYN-------- 255

Mouse   310 SLEINVLGLLIPLGIMLFCYSMIIRTLQHCKN------------EKKNRAVRMIFAVVVLFLGFW 362
             |.|.||...||:.:||.|||::.|.|...::            :.|.:.|||..|:|.:|...|
  Fly   256 -LIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICW 319

Mouse   363 TPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYITQLFR 427
            .||: :.|:......:|..    .:|:.:.......||..:..:||:||:::.::||.|..:
  Fly   320 LPYH-LFFIYAYHNNQVAS----TKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQR--- 376

Mouse   428 TCRGPLVLCKHCDFLQVYSADM---------SSSSYTQS--TVDH 461
                  ::|..|..|..:..|.         ||:.:|:.  ||.|
  Fly   377 ------IICCCCVGLTRHRFDSPKSRLTNKNSSNRHTRGGYTVAH 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ccr4	XP_006511995.1	7tmA_Chemokine_R	147..422	CDD:341319	82/313 (26%)
		TM helix 1	149..173	CDD:341319	4/23 (17%)
		TM helix 2	182..203	CDD:341319	10/29 (34%)
		TM helix 3	218..240	CDD:341319	3/21 (14%)
		TM helix 4	263..279	CDD:341319	3/15 (20%)
		TM helix 5	307..330	CDD:341319	9/22 (41%)
		TM helix 6	345..370	CDD:341319	9/24 (38%)
		TM helix 7	390..415	CDD:341319	6/24 (25%)
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	83/307 (27%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	77/286 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000