Protein Alignment Clock and cyc

DIOPT Version :9

• Sequence 1: NP_001276755.1
• Gene: Clock / 12753
• MGIID: 99698
• Length: 855
• Species: Mus musculus
• Sequence 2: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Alignment Length: 428
• Identity: 129/428 - (30%)
• Similarity: 201/428 - (46%)
• Gaps: 82/428 - (19%)

Mouse     7 CSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVS-----RNKS--EKKRRDQFNVLIKELGSMLP-- 62
            |..|..|.|           |..|::|:.|.|     :|.|  ||:|||:.|..|.||.||:|
  Fly     7 CENMEEIED-----------ENYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMC 60

Mouse    63 -GNARKMDKSTVLQKSIDFLRKHKETTAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIM 126
             ...||:||.|||:.::..||..:.:.:....:  ..|::|:|||::|...::|:|.:||...:.
  Fly    61 FAMQRKLDKLTVLRMAVQHLRGIRGSGSLHPFN--GSDYRPSFLSDQELKMIILQASEGFLFVVG 123

Mouse   127 TD-GSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILST-------HLLESDSLTPE 183
            .| |.|:|||:||:|:|....:||:.||.|:.:...:..:|.:.||:       .|:::.::.|.
  Fly   124 CDRGRILYVSDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPV 188

Mouse   184 YLKSKNQL---------EFCCHM-LR-----------GTIDPKEPST-----------YEYVRFI 216
            .......|         .|.|.| ||           .|......||           |..::..
  Fly   189 KTDVPQSLCRLCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCT 253

Mouse   217 GNFKSLTSVSTSTHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTV-----EEPNEE- 275
            |..||.|.:.....:. :...|.|:..      |.||..|:  |..::. .||     ..||..
  Fly   254 GYLKSWTPIKDEDQDA-DSDEQTTNLS------CLVAIGRI--PPNVRN-STVPASLDNHPNIRH 308

Mouse   276 --FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQY-GKGKSC 337
              |.||||.|.||||:|.||..:||:||.|:||||.|:|:|.:|:..|.:.|:.:||. .|..:.
  Fly   309 VLFISRHSGEGKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQ 373

Mouse   338 YYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTV 375
            .|||..|...:|.||:.:....:.|.|..::|:..::|
  Fly   374 VYRFRCKDNSYIQLQSEWRAFKNPWTSEIDYIIAKNSV 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clock	NP_001276755.1	bHLH-PAS_CLOCK	29..89	CDD:381577	27/69 (39%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:19414601	32..47		7/21 (33%)
		PAS	109..>177	CDD:366402	24/75 (32%)
		PAS_11	274..377	CDD:373151	42/106 (40%)
		Interaction with NR3C1. /evidence=ECO:0000269|PubMed:19141540	371..854		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..411
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..497
		Interaction with SIRT1. /evidence=ECO:0000269|PubMed:18662547	450..570
		Implicated in the circadian rhythmicity	514..564
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..650
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	752..791
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	814..855
cyc	NP_524168.2	HLH	31..84	CDD:278439	23/52 (44%)
		PAS	111..212	CDD:279347	27/100 (27%)
		PAS	111..173	CDD:214512	22/61 (36%)
		PAS_11	311..411	CDD:291273	41/99 (41%)
		PAS	311..406	CDD:238075	40/94 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810