DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clk1 and mnb

DIOPT Version :9

Sequence 1:	NP_001036099.1	Gene:	Clk1 / 12747	MGIID:	107403	Length:	483	Species:	Mus musculus
Sequence 2:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster

Alignment Length:	430	Identity:	130/430 - (30%)
Similarity:	208/430 - (48%)	Gaps:	69/430 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    85 PGHPYGEPGS----RYQMHSSKSSGRSGRSSY-KSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDE 144
            |.| :.||.|    :..:...|:........| |.|.|::.......|..|..|:..:...:||.
  Fly   225 PNH-FREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDN 288

Mouse   145 EGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVL 209
            ..::| ::|:....||||...:|:|:||:||:..||: ....||:||:||...:...||.|:::|
  Fly   289 HDYII-KNGEKFLDRYEIDSLIGKGSFGQVVKAYDHE-EQCHVAIKIIKNKKPFLNQAQIEVKLL 351

Mouse   210 EHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKS 274
            |.:|..|..:.:..|::...|..|.|:|:|||||..:.||.::..:|....::..||.|.|:|.:
  Fly   352 EMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTA 416

Mouse   275 VNFLHSNKLT--HTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHST 337
            :.||.:.:|.  |.||||||||..        |||...         ||:|||||:....:....
  Fly   417 LLFLSTPELNIIHCDLKPENILLC--------NPKRSA---------IKIVDFGSSCQLGQRIYH 464

Mouse   338 LVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMI 402
            .:.:|.||:|||:|.:.:....|:||:||||:|.:.|..:|...:..:.:..:..:||..||:::
  Fly   465 YIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLL 529

Mouse   403 QKTRKRRYFHHDRLDWDEHSSAGRYV------SRRCKPLKEFMLSQDAEHELL------------ 449
            .:..|.|.|      :|:..:.|.||      .|:.||.....|     |::|
  Fly   530 DQAHKTRKF------FDKIVADGSYVLKKNQNGRKYKPPGSRKL-----HDILGVETGGPGGRRL 583

Mouse   450 -------------FDLIGKMLEYDPAKRITLKEALKHPFF 476
                         .|||.:||::||..|:|...||:|.||
  Fly   584 DEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk1	NP_001036099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Nuclear localization signal. /evidence=ECO:0000255	29..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..146		15/65 (23%)
		PKc_CLK1_4	147..476	CDD:271115	113/361 (31%)
		S_TKc	160..476	CDD:214567	110/348 (32%)
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	115/365 (32%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	110/348 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845491
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740