DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AgaP_AGAP003666 and Rnf139

DIOPT Version :9

Sequence 1:	XP_313450.5	Gene:	AgaP_AGAP003666 / 1274343	VectorBaseID:	AGAP003666	Length:	863	Species:	Anopheles gambiae
Sequence 2:	NP_780435.1	Gene:	Rnf139 / 75841	MGIID:	1923091	Length:	668	Species:	Mus musculus

Alignment Length:	748	Identity:	256/748 - (34%)
Similarity:	379/748 - (50%)	Gaps:	164/748 - (21%)

- Green bases have known domain annotations that are detailed below.

Mosquito     3 VVRTKVLGLVDVIMRVPSLFIIDEILKIGMGVPIGQPAGQPANSSAINLDSPPVAAMLPDDDRGM 67
            :.:.:|...::|.:|||.|:|||.|.                ||                    .
Mouse    13 MAQQQVWAALEVALRVPCLYIIDAIF----------------NS--------------------Y 41

Mosquito    68 QDSIEVYKFVSLAVLKFLICLFGAISAACVFMLWTRHLVIVYMY----MVSVGLIFLSYWS---- 124
            .||.:....:.|.:   .:.|.|.:.::.|.:|..|.|...|||    :::...:.::|::
Mouse    42 YDSSQSRFCIGLQI---FLRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHI 103

Mosquito   125 ------NVSALSVISDSPSLLEDVLSLNMDRLLDPGGVLISILPH---------LLAQWLMGVIF 174
                  |.||..                           |.:||.         ::.|...|:
Mouse   104 DFYGAYNTSAFG---------------------------IELLPRKGPSLWMALIVLQLTFGI-- 139

Mosquito   175 AYIHLGPRHKIVQKALPFSFLMPL--LLAMLPL---------PSLVLKHSPAFAAILPLVLSKIA 228
            .|:.|.....|..:.:..:.|:|:  |:..|||         .||:|    .|..:|.|.:....
Mouse   140 GYVTLLQIQSIYSQLMILNILVPIIGLITELPLHIRETVVLMSSLIL----IFNTVLVLAVKLKW 200

Mosquito   229 LWSSSFDVVKTILSGYQHARNFASNFGIATLIENEWQRLNVPCVLRVFWTIRLTEHLVSLL---- 289
            .:.|:..|       |...|:....:|:..|:|:.|:|:..|.:|||||..|:|.....|:
Mouse   201 FYYSTRYV-------YLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRITAQATVLMYILR 258

Mosquito   290 MSSEAPLRFAA------TVQSVLVSGCETLTAVLGMTSIISLICHYIGKMFQLFLLSEDYDEDKS 348
            |::|....|.:      .:.::::|||::...||||:::||.|.||:|.....|:.|.: ::|:.
Mouse   259 MANETESFFISWDDFWDVICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTE-EDDRR 322

Mosquito   349 IGTVSAILFYILALQTGLTSLSPDKRIVRLCRNMCLLVTALLHFLHNIVAPILMSLSAARNPSRK 413
            :|.|:.:||:||||||||:.|.|::|::||.||||||:||:|||:|.:..|:||||||:...|..
Mouse   323 LGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFH 387

Mosquito   414 RHARALIVCAFLLIAPGSLLAVLWASHSPSTWLLAVTAFSVEVIVKVLVSLATYTLFLLDARRQT 478
            ||...|.|.|.|.|.|..|..|||..::.:|||.|||||.||:.:||:|||..||||::|.....
Mouse   388 RHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNV 452

Mosquito   479 FWEKLDDYVYYIRAFGNSVEFCFGIFLFFNGAWILIFESEMIPIGGAIRALMMGIHAYFNIWCEA 543
            .|||||||||::|:.||.:||.||:.:|.|||:.::|||     |..|||.||.:||||||:.:.
Mouse   453 LWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFES-----GSKIRACMMCLHAYFNIYLQV 512

Mosquito   544 RAGWVVFMKRRTAVHKISSLPEATTAQLQQFDDVCAICYQDM-TSAKITRCNHYFHGVCLRKWLY 607
            :.||..||.|||||.||:||||...:.||:.||||||||.:. |||:||.||||||.:|||||||
Mouse   513 KNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLY 577

Mosquito   608 VQDRCPLCHE--------------------IIMNQDGNPGDESLEE-------QLNNGDNVRIEP 645
            :||.||:||:                    |..|::.|| :|:|.|       :||..|:
Mouse   578 IQDTCPMCHQKVYIEDEIKDNSNASNNNGFIAPNENPNP-EEALREDAAGSDRELNEDDS----- 636

Mosquito   646 RTGRPDPSADATNNRLQNVPQQAAIVQGTDQAD 678
             |...|.:....|..:|:....||..:..|..|
Mouse   637 -TDCDDDAQRERNGGIQHTGAAAAAAEFNDDTD 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AgaP_AGAP003666	XP_313450.5	TRC8_N	9..547	CDD:290425	188/581 (32%)
		zf-rbx1	<575..616	CDD:289448	30/41 (73%)
		zf-RING_2	576..616	CDD:290367	29/40 (73%)
Rnf139	NP_780435.1	TRC8_N	19..516	CDD:290425	188/581 (32%)
		zf-rbx1	<544..586	CDD:289448	30/41 (73%)
		RING	547..589	CDD:238093	29/41 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..668		17/72 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	280	1.000	Domainoid score	I1712
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5222
Inparanoid	1	1.050	389	1.000	Inparanoid score	I2080
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	1	1.000	-	-		FOG0008390
OrthoInspector	1	1.000	-	-		oto197860
Panther	1	1.100	-	-	LDO	PTHR22763
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6380
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.930