DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AgaP_AGAP003666 and Trc8

DIOPT Version :9

Sequence 1:	XP_313450.5	Gene:	AgaP_AGAP003666 / 1274343	VectorBaseID:	AGAP003666	Length:	863	Species:	Anopheles gambiae
Sequence 2:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	875	Identity:	462/875 - (52%)
Similarity:	565/875 - (64%)	Gaps:	143/875 - (16%)

- Green bases have known domain annotations that are detailed below.

Mosquito     4 VRTKVLGLVDVIMRVPSLFIIDEILKIGMGV-----------------PIGQPA---GQPANSSA 48
            |||||||||||:||||.:.:||||||:.||:                 |...||   ||...:|.
  Fly     3 VRTKVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFTSI 67

Mosquito    49 INLDSPPVAAMLPDDDRGMQDSIEVYK------------------------FVSLAVLKFLICLF 89
            ..|.|....:.....::.::.:.|..|                        .:|...:||::|:|
  Fly    68 KELFSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLCVF 132

Mosquito    90 GAISAACVFMLWTRHLVIVYMYMVSVGLIFLSYWSNVSALSVISDSPSLLEDVLSLNMDRLLDPG 154
            ..:||||:|||||||||:|||::.|:||.|||||||||||::...|||::||::|||..||||.|
  Fly   133 AFLSAACIFMLWTRHLVMVYMFLTSLGLTFLSYWSNVSALALTERSPSMVEDLMSLNTTRLLDSG 197

Mosquito   155 GVLISILPHLLAQWLMGVIFAYIHLGPRHKIVQKALPFSFLMPLLLAMLPLPSLVLKHSPAFAAI 219
            ||::|:.|||:|||.||::|||||||||.:.||:::|..|..|:||||||||:.|::|.|..|..
  Fly   198 GVVMSLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPIIFASPILLAMLPLPAKVVQHLPVVAVF 262

Mosquito   220 LPLVLSKIALWSSSFDVVKTILSGYQHARNFASNFGIATLIENEWQRLNVPCVLRVFWTIRLTEH 284
            .|::|:||.|..|:.:..:|:.:|||:|.||.||||::.||||||||||||.||||||||||.:.
  Fly   263 TPIILTKITLMQSAMEASRTVYNGYQYAMNFVSNFGLSALIENEWQRLNVPNVLRVFWTIRLIQG 327

Mosquito   285 LVSLLMS-SEAPLRFAATVQSVLVSGCETLTAVLGMTSIISLICHYIGKMFQLFLLSEDYDEDKS 348
            ..:|..: |:.||......|.:||.||||:|||||||.:||:.|||||:.||.:||:.| ||:||
  Fly   328 GYALATTESDEPLDLMTATQKLLVDGCETMTAVLGMTGVISMFCHYIGRGFQWYLLTYD-DEEKS 391

Mosquito   349 IGTVSAILFYILALQTGLTSLSPDKRIVRLCRNMCLLVTALLHFLHNIVAPILMSLSAARNPSRK 413
            :|||||:|||||||||||||||||||.:|||||:|||:|||||||||||:|||||||||||||||
  Fly   392 LGTVSAVLFYILALQTGLTSLSPDKRFIRLCRNLCLLMTALLHFLHNIVSPILMSLSAARNPSRK 456

Mosquito   414 RHARALIVCAFLLIAPGSLLAVLWASHSPSTWLLAVTAFSVEVIVKVLVSLATYTLFLLDARRQT 478
            ||.|||.|||||::...|||..||:..|.||||||||||||||:||||||||||||||||||||.
  Fly   457 RHVRALSVCAFLVVLSVSLLYHLWSQQSISTWLLAVTAFSVEVVVKVLVSLATYTLFLLDARRQF 521

Mosquito   479 FWEKLDDYVYYIRAFGNSVEFCFGIFLFFNGAWILIFESEMIPIGGAIRALMMGIHAYFNIWCEA 543
            ||||||||:||:|||||||||||||.||.||||||||||.....||.|||:||.|||||||||||
  Fly   522 FWEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEA 586

Mosquito   544 RAGWVVFMKRRTAVHKISSLPEATTAQLQQFDDVCAICYQDMTSAKITRCNHYFHGVCLRKWLYV 608
            ||||.||||||:||||||:|||||.||||.||||||||||:|.|||||||.|:||||||||||||
  Fly   587 RAGWSVFMKRRSAVHKISALPEATPAQLQAFDDVCAICYQEMYSAKITRCRHFFHGVCLRKWLYV 651

Mosquito   609 QDRCPLCHEIIMNQDGNPGDESLEEQLNNGDNVRIEPRTGRPDPSADATNNRLQNVPQQAAIVQG 673
            ||||||||||:|..|  ..||:..|              ..|.|:|
  Fly   652 QDRCPLCHEIMMYTD--KADENAPE--------------AEPAPAA------------------- 681

Mosquito   674 TDQADQPPAQPLFDDRYFEEQINNISRAASASRSMVGIRAGQTDAQTDASKRAPHHPEEQYRDEY 738
              ||:||..      .|..:..||.:                  ||..:.:|||....||
  Fly   682 --QAEQPMR------IYPRDDANNAA------------------AQRRSPERAPVEASEQ----- 715

Mosquito   739 GVTMRFGARENAHLYANNPAGIAAPQPSSGGTTGTVDGNYPSGSNSSDGSPSSSSSSSNTEDTGS 803
                                   ||..||.....|:      |:.:......|:::........|
  Fly   716 -----------------------APATSSSSAAATI------GAEAVSAIVESAAAVGEARSLVS 751

Mosquito   804 MSSGSSASSSASGTLSGLSNSSLMSAAAIS 833
            ::|.|||:...|.  ||.|:||.|:|:|.|
  Fly   752 VASSSSATHRISA--SGSSDSSYMTASAQS 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AgaP_AGAP003666	XP_313450.5	TRC8_N	9..547	CDD:290425	349/582 (60%)
		zf-rbx1	<575..616	CDD:289448	36/40 (90%)
		zf-RING_2	576..616	CDD:290367	35/39 (90%)
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	320/468 (68%)
		zf-rbx1	<618..659	CDD:289448	36/40 (90%)
		zf-RING_2	619..659	CDD:290367	35/39 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	680	1.000	Domainoid score	I477
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5222
Inparanoid	1	1.050	831	1.000	Inparanoid score	I1347
OMA	1	1.010	-	-		QHG27221
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	1	1.000	-	-		FOG0008390
OrthoInspector	1	1.000	-	-		oto110991
Panther	1	1.100	-	-	LDO	PTHR22763
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6380
TreeFam	1	0.960	-	-
	13	12.940