DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AgaP_AGAP010356 and RNF150

DIOPT Version :9

Sequence 1:	XP_559104.3	Gene:	AgaP_AGAP010356 / 1272683	VectorBaseID:	AGAP010356	Length:	361	Species:	Anopheles gambiae
Sequence 2:	XP_005263207.1	Gene:	RNF150 / 57484	HGNCID:	23138	Length:	460	Species:	Homo sapiens

Alignment Length:	331	Identity:	126/331 - (38%)
Similarity:	186/331 - (56%)	Gaps:	47/331 - (14%)

- Green bases have known domain annotations that are detailed below.

Mosquito    48 TEFSNGVSSFALPAEDRMAIESSTLAYLNYSFTGPDGHLIEFGSESAKYGEGRVLNRSGLLVHIS 112
            |.|.|  .::|.||.|..|..:.          |....|....:|..:|||......:...|.::
Human    41 TAFVN--ITYAEPAPDPGAGAAG----------GGGAELHTEKTECGRYGEHSPKQDARGEVVMA 93

Mosquito   113 NSANHSDHTGCSKQWSGTLGGTIPERDAPWIALVRRGSCNFEDKVKHAYERGAAGIIIYN---DK 174
            :||:  |...|.....    ...|.|...||||:.:|:|.:.||:::|:.:.|:.::|:|   :.
Human    94 SSAH--DRLACDPNTK----FAAPTRGKNWIALIPKGNCTYRDKIRNAFLQNASAVVIFNVGSNT 152

Mosquito   175 NDT-----------KLEKMK--------INDKERNITAVFTTNAMGRELIEILEVHRSV-VQMRI 219
            |:|           ..:.:|        ::....:|.|:......|:|::.:||  |:: |.|.|
Human   153 NETITMPHAGLMSSHAQPLKLISPCPYSLSSGVEDIVAIMIPEPKGKEIVSLLE--RNITVTMYI 215

Mosquito   220 IEGSRQFRNLGNINRTSVLFVSISFIVLMIISLVWLVFYYVQRFRYLQTKDKQSKRLCSVAKRII 284
            ..|:|..:..  ::||||:||||||||||||||.||||||:|||||...:|:..:||...||:.|
Human   216 TIGTRNLQKY--VSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRYANARDRNQRRLGDAAKKAI 278

Mosquito   285 AKIPTKSIKSDDKEIDNDC--CAICIEPYKVTDVIRVLPCKHEFHKVCIDPWLLEHRTCPMCKMD 347
            :|:..::||..|||.::|.  ||:|||.||..||:|:|||:|.|||.|:|||||:|||||||||:
Human   279 SKLQIRTIKKGDKETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMN 343

Mosquito   348 ILKHYG 353
            |||..|
Human   344 ILKALG 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AgaP_AGAP010356	XP_559104.3	PA_GRAIL_like	76..219	CDD:239037	37/165 (22%)
AgaP_AGAP010356	XP_559104.3	zf-RING_2	302..345	CDD:290367	30/44 (68%)
RNF150	XP_005263207.1	PA_GRAIL_like	45..215	CDD:239037	43/189 (23%)
		UPF0233	<229..>254	CDD:299753	22/24 (92%)
		zf-RING_2	298..341	CDD:290367	29/42 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BHU7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880