DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clcn2 and ClC-a

DIOPT Version :9

Sequence 1:	XP_017172351.1	Gene:	Clcn2 / 12724	MGIID:	105061	Length:	915	Species:	Mus musculus
Sequence 2:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster

Alignment Length:	1101	Identity:	453/1101 - (41%)
Similarity:	602/1101 - (54%)	Gaps:	231/1101 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    25 YEQTLMYGRYTQELGAFAKEEAARIRLGGPEPWKGSPSARATPELLEYGQSRCARCRICSVRCHK 89
            |..||||||||::||.|||:||.::::  .|..:.....:...|||....:|..|   .|....:
  Fly   103 YIDTLMYGRYTKDLGEFAKDEARKLKI--LEKRRKQEDKQRNKELLGKHSTRAKR---VSSWIWR 162

Mouse    90 FLVSRVGEDWIFLVLLGLLMALVSWAMDYAIAVCLQGEGKGWRAQQWMSRGLNTNILLQYLAWVT 154
            ..|:|:||||:||.|||::|||:|:.||..|::|.       .|:.|:.|.|.:...:||:|||:
  Fly   163 HTVARLGEDWVFLALLGIIMALLSFIMDKGISICT-------NARIWLYRDLTSQPFVQYIAWVS 220

Mouse   155 YPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGK 219
            .||.||.|||||..::|||::||||||||||||||.||||||.||.||||||||..|||||||||
  Fly   221 LPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGK 285

Mouse   220 EGPFVHIASMCAALLSKFLSLFGGIYEHESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTF 284
            |||||||||:.|.||||.::.|.||||:||||:||||||||||||.|||||:||||||||||:|:
  Fly   286 EGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTY 350

Mouse   285 FAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFG 349
            |||||||||||||...|.:||:||||.::.:|:.|||.|.|..:||||.|||..||:||:..|.|
  Fly   351 FAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLG 415

Mouse   350 GALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVT 414
            ||.:|:::|:.|..||..|.:|:||.:.|.|:|..:.||:|:::||.|.|||:||:||..|.:..
  Fly   416 GASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQ 480

Mouse   415 LFDNRTWVRQGLVEDLELPSTSQAWSPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFV 479
            ||.|.||.|..|.  :|..:....|.....:||..|||:.|..|.:|.:|:|||||.|.|:|||.
  Fly   481 LFSNFTWSRDDLT--VEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFK 543

Mouse   480 IGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIA 544
            |||.|||||||.||..||.|:........|:|||||||||||.:|:||||||.|||:||:||||.
  Fly   544 IGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQIT 608

Mouse   545 HILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALS 609
            |::||||||::|||||..||||:|||||.||||||||:|.......|.:.|||.|||||.::...
  Fly   609 HVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHG 673

Mouse   610 CTFRDLR--LALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQKLRK--- 669
            .:::.|:  |.|::|. |.|.||:||::||||||::|.:::.::...:...:|.:..||.:|
  Fly   674 ISYQKLKEVLKLNKTL-RSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQ 737

Mouse   670 --------------AQLSPPSDQESPPSSE-TSIRFQVNTE----DSGFSGAHGQTHKPLKPALK 715
                          .::..||..|..|:.: .|:|...|.|    .......||.. .|.|..||
  Fly   738 ERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSL-APRKSILK 801

Mouse   716 R-------------GPSNSTSLQEGTTGNMESAGIALRSLF------------------CGS-PP 748
            :             |.|.|.:.....|||.|   ..:||.|                  .|| .|
  Fly   802 KTNSFNLKTYAQPMGHSPSITPYTTITGNSE---FRIRSAFEAIFKKSTTLQDVQPDPETGSLSP 863

Mouse   749 LEATSELE--------------------------------------------------------- 756
            ..:..|:|
  Fly   864 AASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNN 928

Mouse   757 ----KSESCDKRKLKRV--------------RISLASD--------------------------- 776
                |.....|.|..:|              :|..|::
  Fly   929 GDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDV 993

Mouse   777 ---SDPEA-------------------EMSPEEILEWEEQQLDEPVNF--SDCKIDPAPFQLVER 817
               ::||:                   :||||:..:||.:::.:|::.  ::..|||:|||||||
  Fly   994 DETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVER 1058

Mouse   818 TSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGV------------KVRPP 870
            ||:.|.|::||::|::|||||.||||:|:|.|||||||||...:...|            .|..|
  Fly  1059 TSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAVEKP 1123

Mouse   871 LASFR-------------DSATSS----SDTETTEV-HALWGPRSRHGLPREGTPSDSDDK 913
            |.|..             |||.|:    ||.|...: |...|..|....|:|...|.|.||
  Fly  1124 LLSTNSSDKAVDMTVTSMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSADK 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clcn2	XP_017172351.1	ClC_1_like	98..582	CDD:239655	292/483 (60%)
		CBS_pair_voltage-gated_CLC_euk_bac	594..855	CDD:341367	106/442 (24%)
		CBS repeat	600..806	CDD:341367	69/387 (18%)
		CBS repeat	812..854	CDD:341367	28/41 (68%)
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	292/483 (60%)
		Voltage_CLC	227..615	CDD:279048	239/389 (61%)
		CBS_pair_EriC_assoc_euk_bac	1000..1096	CDD:239964	41/95 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	495	1.000	Domainoid score	I361
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3213
Inparanoid	1	1.050	767	1.000	Inparanoid score	I539
Isobase	1	0.950	-	0	Normalized mean entropy	S3158
OMA	1	1.010	-	-		QHG52624
OrthoDB	1	1.010	-	-		D1131873at2759
OrthoFinder	1	1.000	-	-		FOG0002718
OrthoInspector	1	1.000	-	-		otm44235
orthoMCL	1	0.900	-	-		OOG6_103492
Panther	1	1.100	-	-	LDO	PTHR45720
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4171
SonicParanoid	1	1.000	-	-		X544
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820