DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNTN1 and Cont

DIOPT Version :9

Sequence 1:	NP_001834.2	Gene:	CNTN1 / 1272	HGNCID:	2171	Length:	1018	Species:	Homo sapiens
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1051	Identity:	328/1051 - (31%)
Similarity:	495/1051 - (47%)	Gaps:	122/1051 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    26 RRYGHGVSEEDK---GFGPIFEEQPINTIYP--EESLEGKVSLNCRARASPFPVYKW-------- 77
            |.|.:|:...|.   ..||.|.:||.:|.:.  :..|...|:|:|.|...|.|.|.|
  Fly   344 RPYHYGLDINDMERIPRGPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDD 408

Human    78 RMNNGDVD-LTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPE 141
            |:....:| |..|||::.||||:|..|.:..|.|.|:|:|.|.:|.:||..|.|:||::..|..:
  Fly   409 RLEYQKIDPLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLK 473

Human   142 ERPEV-RVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASD 205
            ...|. .:..||.  :.||||.|:| |:.|.|..:.||.|:..|:|.|||: :|.||.:.:|..|
  Fly   474 RSAETSEMNWGKS--IFCDPPQHYP-DVRYYWARDYFPNFVEEDQRVFVSR-DGALYFSFIETVD 534

Human   206 KGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQ-FKDVY---ALMGQNVTLECFAL 266
            :.||||.|.:..........|.||...|...   |.|.|... |..|:   .:.|..:.|||.|.
  Fly   535 RANYSCTVQTLVSDTGRNGPFFPLRVTPNSN---YQALIFANTFPKVFPEAPVAGDEIRLECMAF 596

Human   267 GNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFP 331
            |.|:|...|.:...|:...|.....|.||.|.|....|.|.|.|...|.|........|.:|..|
  Fly   597 GYPIPSYNWTRQGLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRP 661

Human   332 EWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGEL---------RLYDVTF---- 383
            ::...:.|...|..||:.:.|.|...|.....|.||........:         .:..:.|
  Fly   662 QFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKD 726

Human   384 ENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSW 448
            ::..||||.|:|.....:::|:|::|::.|:|:.:|::.::.|...|...|.|.|:|||:|||.|
  Fly   727 KDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQW 791

Human   449 SKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPIN 513
            .|..:.:.:.....|...|:|.|:..:|:|.|||||.|.|..|...|...:::....|.|..|..
  Fly   792 KKDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQ 856

Human   514 ADITVGENAT-MQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKH 577
            ..::...:.. :.|.|:||..||:.:||..||.|:   |.|.......::|.| .|.:.|..::.
  Fly   857 RIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVL---KNNHDGTGRIIVDWN-RLTVHNTSMRD 917

Human   578 AGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTK 642
            ||.|.|..::.|:..|:...:.:.|.||.|||:::..|..|...:.|..||.|...|..|.|..:
  Fly   918 AGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGR 982

Human   643 TILSDDWKDAKTDPPIIE----GNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDG 703
            |..:..|.:..|.....|    .:.:.|..|:|.||..|||.|.|.|.||.|.||.||....|..
  Fly   983 TNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYE 1047

Human   704 AAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEW-----KK-----VT 758
            ..|.:||.:||||||:..:|||||.||..:..:.:...|.|.:|.....||     ||     |.
  Fly  1048 DKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVA 1112

Human   759 VTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSS 823
            |.|.....|.         |.::|||:|.|:.|.||.|.:|||:||:|.|..||.:......:|:
  Fly  1113 VVNIPLNNYY---------TEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNST 1168

Human   824 EISVHW-------EHVLEKIVESYQIRYW-AAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIE 880
            ..:|.|       |::..|:: .::::|| ..|.:|::...:..|::.: |.:..|.|||.||::
  Fly  1169 CFNVTWQPIDMSRENIRGKLI-GHRLKYWKTTHQEEDSVYYLSRTTRNW-ALIVGLQPDTYYFVK 1231

Human   881 VGACNSAGCGPPSDMIEAFTKKAPPSQPPRII-------SSVRSGSRYIITWDHVVALSNESTVT 938
            |.|.|:||.||.|:..|..|.:..|.:||..:       |:||      :.|.:|....:|..|.
  Fly  1232 VMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVR------VVWRYVSPSQDEEPVE 1290

Human   939 GYKVLYRPDGQHDGKLYSTHKHSIE-----VPIPRDGE-----------YVVEVRAHSDGGDGVV 987
            ||||          :::.:.::.|.     |||.:..|           |.:.|.|:|:||||.:
  Fly  1291 GYKV----------RIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRM 1345

Human   988 SQVKISGAPTL 998
            |      :|||
  Fly  1346 S------SPTL 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNTN1	NP_001834.2	Ig1_Contactin-1	40..132	CDD:143257	38/102 (37%)
		I-set	41..130	CDD:254352	36/99 (36%)
		Ig2_Contactin-2-like	134..230	CDD:143204	33/96 (34%)
		IG_like	144..221	CDD:214653	30/77 (39%)
		Ig3_Contactin-1	241..328	CDD:143259	27/90 (30%)
		IG_like	249..327	CDD:214653	24/80 (30%)
		I-set	331..408	CDD:254352	20/89 (22%)
		Ig	332..408	CDD:299845	19/88 (22%)
		IG_like	422..501	CDD:214653	28/78 (36%)
		Ig5_Contactin-1	429..501	CDD:143260	27/71 (38%)
		IG_like	511..600	CDD:214653	24/89 (27%)
		Ig6_Contactin_like	520..601	CDD:143171	23/81 (28%)
		FN3	610..697	CDD:238020	30/90 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..717		10/23 (43%)
		FN3	709..801	CDD:238020	37/101 (37%)
		fn3	811..893	CDD:278470	26/89 (29%)
		FN3	905..989	CDD:238020	27/106 (25%)
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	36/98 (37%)
		I-set	362..462	CDD:254352	36/99 (36%)
		Ig	466..559	CDD:299845	33/96 (34%)
		IG_like	584..657	CDD:214653	23/72 (32%)
		IGc2	586..645	CDD:197706	20/58 (34%)
		Ig	667..751	CDD:299845	19/83 (23%)
		IG_like	676..751	CDD:214653	17/74 (23%)
		IG_like	765..844	CDD:214653	28/78 (36%)
		Ig	773..844	CDD:299845	27/70 (39%)
		I-set	851..940	CDD:254352	25/92 (27%)
		Ig	866..944	CDD:299845	24/81 (30%)
		FN3	944..1043	CDD:238020	36/98 (37%)
		FN3	1053..1146	CDD:238020	37/101 (37%)
		fn3	1156..1244	CDD:278470	26/89 (29%)
		fn3	1259..1346	CDD:278470	26/102 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9318
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1415
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm41700
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3370
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770